The Role of Advanced Age and Duration of Infertility on Oocyte Number Retrieved during In Vitro Fertilization
Vol. 9 No. 2 (2014): Oktober 2014
Original Article
September 29, 2016
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Method: This was an analytic observational study, including infertile female patients who followed the in vitro fertilization program at Fertility Clinic Graha Amarta Dr Soetomo Hospital Surabaya. Total sampling was conducted during January 1st-June 30th 2014 and found 66 study subjects. Evaluation was performed on age, duration of infertility and the number of oocytes retrieved following ovarian stimulation using FSH and GnRH antagonist injection. All data were analyzed by ANOVA test with level significance of ≤ 0.05.
Result: In the group of age <35 years the average number of oocytes retrieved was 9.43 ± 6.29 oocytes, and in the group of age ≥ 35 years averaged number was 6.03 ± 4.67 oocytes. There was significant differences of oocytes number retrieved between the two groups (p = 0.017). The number of oocytes retrieved in group of duration of infertility 1-2 years, 3-4 years and ≥ 5 years were 13.40 ± 3.28 ; 8.64 ± 6.80 and 6.82 ± 5.45, respectively. There was significant differences of oocytes number retrieved between the three groups of duration of infertility (p = 0.017).
Discussion: The advanced of age and the longer duration of infertility may contribute to the incidence of the less number of oocytes retrieved in infertile women who follow in vitro fertilization.
Hendarto, H. (2016). The Role of Advanced Age and Duration of Infertility on Oocyte Number Retrieved during In Vitro Fertilization. Jurnal Ners, 9(2), 183–186. https://doi.org/10.20473/jn.v9i2.2539
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American Society for Reproductive Medicine (ASRM). 2006. Aging and infertility in women. Fertil Steril 86(4), 248–251
Arslan M, Bocca S, Mirkin S, Barroso G, Stadtmauer L, Sergio Oehninger S. 2005. Controlled ovarian hyperstimulation protocols for in vitro fertilization: two decades of experience after the birth of Elizabeth Carr. Fertil Steril_ 84: 555– 569.
Berga SL and Loucks TL. 2007. Stress Induced Anovulation. Elsevier Inc. All rights reserved. 615–630
Brosens I, Gordts S, Valkenburg M, Puttemans P, Campo R and Gordts S. 2004. Investigation of the infertile couple: when is the appropriate time to explore female infertility? Hum Reprod 19, 8: 1689–1692.
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