Epidemiological Study of Clinical and Laboratory Profiles of Patients with Acute Lymphoblastic Leukemia at Dr. Soetomo Hospital Surabaya
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Introduction: Considering the high number of acute lymphoblastic leukemia (ALL) and it being the type of cancer with the highest fatality rate among the children, this study seeks to determine the epidemiological description of the clinical and laboratory profiles of patients with ALL.
Methods: This research used a descriptive study by using medical data record of patients with ALL. The research variables were gender, age, leukemia history of the patient's family, nutritional status, symptoms and signs, laboratory examination, ALL subtypes, risk factors, and result outcomes. All data presented descriptively.
Results: From a total of 50 patients, 54 % of them were male aged 1,5 – 10 years old. 84% of the patients' family had no medical record related to leukemia. 42% of the patient malnutrition. Pale (78%), fever (64%), pain (32%), hepatomegaly (38%), lymphadenopathy (28%), splenomegaly (26%), patients with anemia (82%), leukocytosis (38%), thrombocytopenia (54%). The highest types were ALL–LI (68%), SR-ALL (54%), and remission outcome reached 82%.
Conclusion: Insidence higher in male, aged 1,5 – 10 years old, malnourished at the start of the diagnosis. Most of the patients' family had no medical history of leukemia. Symptoms and medical signs mostly appeared were pale, fever, and bone/joint pain. The physical examination showed hepatomegaly, lymphadenopathy, and splenomegaly and laboratory first test showed the patients had anemia, leukocytosis, and thrombocytopenia.
Ward E, DeSantis C, Robbins A, Kohler B and Jemal A. Childhood and adolescent cancer statistics, 2014. CA: A Cancer Journal for Clinicians. 2014; 64: 83-103.
Widiaskara I, Permono B, Ugrasena I and Ratwita M. Luaran Pengobatan Fase Induksi Pasien Leukemia Limfoblastik Akut pada Anak di Rumah Sakit Umum Dr. Soetomo Surabaya. Sari Pediatri. 2016; 12: 128-34.
Kaushansky K, and more. Williams Hematology (9th Ed.). 2016.
Hunger SP, Lu X, Devidas M, et al. Improved Survival for Children and Adolescents with Acute Lymphoblastic Leukemia between 1990 and 2005: a Report from the Children's Oncology Group. Journal of Clinical Oncology. 2012; 30: 1663.
Pizzo PA and Poplack DG. Principles and Practice of Pediatric Oncology. Lippincott Williams & Wilkins, 2015.
Jatav J, Jain B and Niranjan AK. Clinicopathological Study of Acute Lymphoblastic Leukemia-a Multiparameter Study. Cough. 2015; 2: 5.4.
Carceller E, Ruano D, Madero LL and Lassaletta Á. Two Siblings with Acute Lymphoblastic Leukaemia: Chance or Genetics? Anales de Pediatria (Barcelona, Spain: 2003). 2017, p. 170.
Shalal HH, Mahmood NS and Alchalabi MAQ. Clinical, Hematological, and Laboratory Presentation of Acute Lymphoblastic Leukemia of Children in Diyala Province/Eastern Iraq. 2017. 2017; 5: 7.
Pui C-H, Boyett J, Rivera G, et al. Long Term Results of Total Therapy Studies 11, 12 and 13A for Childhood Acute Lymphoblastic Leukemia at St Jude Children's Research Hospital. Leukemia. 2000; 14: 2286.
Pui CH, Robison LL and Look AT. Acute Lymphoblastic Leukaemia. Lancet (London, England). 2008; 371: 1030-43.
Inaba H, Pei D, Wolf J, et al. Infection Related Complications During Treatment for Childhood Acute Lymphoblastic Leukemia. Annals of Oncology. 2016; 28: 386-92.
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