Head Computed Tomography Images of HIV/AIDS Patients with Suspected Cerebral Toxoplasmosis in Dr. Soetomo General Hospital Surabaya

Ria Wibawani, Bambang Soeprijanto, Widiana Ferriastuti, Erwin A Triyono

= http://dx.doi.org/10.20473/bhsj.v2i1.13343
Abstract views = 425 times | downloads = 912 times


Introduction: Toxoplasma gondii is an intracellular pathogenic parasite with the majority of co-infections occurring in HIV/AIDS patients. This study assesses the head computed tomography (CT) images of cerebral toxoplasmosis in patients with HIV/AIDS.

Methods: This study was a cross-sectional design using head CT images of 35 HIV/AIDS patients with suspected cerebral toxoplasmosis. Variables include lesion type, location, size, CD4 count, and therapeutic result with anti-cerebral toxoplasmosis. All data analysed descriptively.

Results: From total 110, 35 patients met the inclusion criteria. 24 patients (68.6%) were male and 11 (31.4%) female, average age, was 36.1. 8 patients (22.3%) had lesions in cortical, 31 patients (88.6%) had < 1 cm lesion. Single lesions mainly calcified and found in the right centrum semiovale while multiple lesions were subcortical. A hypodense lesion with rim or nodular contrast enhancement is found in 75% of patients with CD4 > 200 in contrast to slight rim contrast enhancement and perifocal edema in patients with CD4 < 200. 20 patients (57.4%) had improved condition after anti-toxoplasmosis therapy.

Conclusion: Cerebral toxoplasmosis lesions in HIV/AIDS patients have various types of imaging findings, mostly multiple, with most frequent location being cortical and diameter < 1 cm. Total recovery is achieved in the majority of patients with therapy.


HIV/AIDS; Head CT; Cerebral Toxoplasmosis

Full Text:



Muluye D, Wondimeneh Y, Belyhun Y, et al. Prevalence of Toxoplasma gondii and Associated Risk Factors Among People Living with HIV at Gondar University Hospital, Northwest Ethiopia. ISRN Tropical Medicine. 2013; 2013.

Wang Z-D, Liu H-H, Ma Z-X, et al. Toxoplasma gondii Infection in Immunocompromised Patients: a Systematic Review and Meta-analysis. Frontiers in Microbiology. 2017; 8: 389.

Rumboldt Z, Castillo M, Huang B and Rossi A. Brain Imaging with MRI and CT: An Image Pattern Approach. Cambridge University Press, 2012.

Sriwidyani NP. Cerebral Toxoplasmosis in Aid Patient A Case Report and Review Literature. International Journal of Science and Research. 2017: 1445-7.

Nissapatorn V, Lee C, Quek KF, Leong CL, Mahmud R and Abdullah KA. Toxoplasmosis in HIV/AIDS Patients: A Current Situation. Japanese Journal of Infectious Diseases. 2004; 57: 160-5.

Ambrosioni J, Alvarez-Martínez MJ, Berenguer J and Miró JM. Toxoplasmosis in HIV-Infected Patients. Encyclopedia of AIDS. 2014: 1-14.

Kastrup O, Wanke I and Maschke M. Neuroimaging of Infections. NeuroRx. 2005; 2: 324-32.

Mendez OA and Koshy AA. Toxoplasma gondii: Entry, Association, and Physiological Influence on the Central Nervous System. PLoS Pathogens. 2017; 13: e1006351.

Kamerkar S and Davis PH. Toxoplasma on the Brain: Understanding Host Pathogen Interactions in Chronic CNS Infection. Journal of Parasitology Research. 2012; 2012.

Hongsakul K and Laothamatas J. Computer Tomographic Findings of the Brain in HIV Patients at Ramathibodi Hospital. Medical journal of the Medical Association of Thailand. 2008; 91: 895.

Sanei Taheri M, Karimi MA, Haghighatkhah H, Pourghorban R, Samadian M and Delavar Kasmaei H. Central Nervous System Tuberculosis: An Imaging Focused Review of a Reemerging Disease. Radiology Research and Practice. 2015; 2015.

Nissapatorn V, Lee C, Cho S, et al. Toxoplasmosis in HIV/AIDS patients in Malaysia. Southeast Asian Journal of Tropical Medicine and Public Health. 2003; 57: 18.9.


  • There are currently no refbacks.

Copyright (c) 2019 Ria Wibawani, Bambang Soeprijanto, Widiana Ferriastuti, Erwin A Triyono

Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.


Creative Commons License

This Journal (E-ISSN:2620-8636) is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

View BHSJ Stats