Characteristics and Histopathological Grading of Malignant Spiculated Mass in regards to Histopathological Grading of Breast Cancer Based on The Nottingham Grading System

Andi Syarti, Ulinta Pasaribu, Dyah Fauziah, Lies Mardiyana, Tri Wulanhandarini

= http://dx.doi.org/10.20473/bhsj.v3i1.19134
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Abstract


Introduction: Spiculation in mammography is a typical finding for invading breast cancer and is an important criterion in diagnosis and in predicting prognostic and plays an important role in management. The purpose of this research is to determine the characteristics of malignant spiculating mass in mammography in regards to histopathological grading using The Nottingham Grading System.
Methods: Patients whom had spiculation in mammography was reviewed using medical record data by two breast imaging consultants and then combined with The Nottingham Grading System criteria obtained from histopathological examination results of core biopsy and surgery specimen. There was 29 cases that met the inclusion criteria.
Results: Of the 29 patients that met the inclusion, the spiculated masses grade I, II has mitotic index of 0-12, grade III has mitotic index of 13-25. Histopathologic grade II, III has the most tubular formation of <10%, grade I has 10-75%. Grade I, II has moderate nuclear pleomorphism, grade III has severe nuclear pleomorphism. Most were grade III (44.8%), followed by grade II (37.9%), and minimally grade I (17.2%). Most patients are in stage 3 breast cancer.
Conclusion: Malignant spiculated mass with grade I, II has low proliferation index (mitotic index 0-12), histopathological grade II, III had worse cellular differentiation (tubular formation <10%), histopathological grade II, III has moderate to severe nuclear pleomorphism.

Keywords


Malignant mass; Mammographic speculation; The Nottingham Grading System

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References


Sun S, Zhang B, Zhao H, Cao X. Association between mammographic features and clinicopathological characeteristics in invasive ductal carcinoma of breast cancer. Molecular and Clinical Oncology 2014;2:623-629.

Health ministry of Indonesia. Kementrian kesehatan ajak masyarakat cegah dan kendalikan kanker. http//www.depkes.go.id/article/view/17020200002/kementerian-hesehatan-ajak-masyarakat-cegah-dan-kendalikan-kanker.html. Accesed 02 Februari 2017.

Sun Y, Zhao Z, Yang Z, Xu F, Lu H, et al. Risk factors and prevention of breast cancer. International Journal of Biological Sciences 2017;13(11):1387-1397.

Liu S, Wu X, Xu W, Lin Q, Liu X, Li Y. Is there a correlation between the presence of a spiculated mass on mammogram and luminal A subtype breast cancer? Korean Journal of Radiology 2016;17(6):846-852.

Fischer U, Baum F, Lutfner-Nagel S. Breast cancer: Diagnostic imaging and therapeutic guidance. New York: Thieme; 2018. p.2-21.

Lamb P, Perry N, Vinnicombe S, Wells C. Correlation between ultrasound characteristics, mammographic findings and histological grade in patients with invasive ductal carcinoma of the breast. Clinical Radiology 2000(55):40-44.

Boisserie-Lacroix M, Hurtevent-Labrot G, Lippa N, Bullier B, Grogan G. Correlation between imaging and prognostic factor: Molecular classification of breast cancer. Diagnostic and Interventional Imaging 2014;95:227-233.

Rakha E, Reis-Filho J, Baehner F, Dabbs DJ, Decker T, Eusebi V, et al. Breast cancer prognostic classification in the molecular era: the role of histological grade. Breast Cancer Research 2010;12(4):207.

Moiruchi H, Yamaguchi J, Hayashi H, Ohtani H, Shimokawa I, Abiru H, et al. Cancer cell interaction with adipose tissue: Correlation with the finding of spiculation at mammography. Radiology 2016;279(1):56-64.

Kim Y, Lin Q, Glazer P, Yun Z. Hypoxic tumor microenvironment and cancer cell differentiation. Curr Mol Med 2009;9(4):425-434.

Muz B, Puente P, Zab F, Azab A. The role of hypoxia in cancer progression, angiogenesis, metastasis, and resistance to therapy. Hypoxia (Auckl) 2015;3:83-92

Rausch L, Netzer N, Hoegel J, Pramsohler S. The linkage between breast cancer, hypoxia, and adipose tissue. Frontiers in Oncology 2017;2;211.

Petrova V, Annicchiarico-Petruzzelli M, Melina G, Amelio I. The hypoxic tumour microenvironment. Oncogenesis 2018;7:10.

Jogi A, Vaapil M, Johansson M, Pahlman S. Cancer cell differentiation heterogeneity and aggressive behaviour in solid tumors. Upsala Journal of Medical Sciences 2012;117(2):217-224.

Ross J, Hatzis C, Symmans W, Pusztai L, Hortobagyi G. Commercialized multigene predictors of clinical outcome for breast cancer. The Oncologist 2018;13:477-493.


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