The Potential Effect Of Sweet Potato (Ipomoea batatas L.) Extract On Total Cholesterol And Low-Density Lipoprotein (LDL) In Hypercholesterol-Model Wistar Rat (Rattus norvegicus)
Downloads
Introduction: CHD has high development among 86% in the world with the prevalence in urban (0.6%) than rural (0.4 %) areas. Atherosclerosis is an inflammatory response in blood vessels due to hypercholesterolemia and oxidized LDL. LDL and total cholesterol levels can be reduced by anthocyanins compounds, which are contained in purple sweet potato (Ipomoea batatas L.) This study aimed to determine the effectiveness of purple sweet potato extract in reducing total cholesterol and LDL.
Methods: This study was a post-test-only control group experimental design. Twenty-five Wistar rats were divided into five groups: normal control, negative control, and three treatment groups fed by purple sweet potato extract doses of 66.67, 133.33, and 266.67 mg/kg BW/day.
Results: Based on the statistical analysis there were significant differences between the treatment group and control groups. The highest dose of purple sweet potato extract (266.67 mg/kg BW/day) has an optimal effect in decreasing total cholesterol and LDL levels.
Conclusion: Purple sweet potato extract (266.67 mg/kg BW/day) can reduce total cholesterol and LDL levels of Wistar Rats.
Okada T, Ayada, K, Usui, S, Yokota K, Cui J, Kawahara Y, Inaba Y, Hirohata S, Mizuno M, Yamamoto D, Kusachi S, Matsuura E, Oguma K. Antibodies against heat shock protein 60 derived from Helicobacter pylori: Diagnostic implications in cardiovascular disease. Journal of Autoimmunity. 2007;29:106-151.
Dwivedi WHO. Cardiovascular diseases (CVDs), World Health Organization. 2015. http://www.who.int/mediacentre/factsheets/fs317/en/>
Riskesdas. Basic Health Research, Health Research and Development Agency, Indonesia Ministry of Health, Ministry of Health of the Republic of Indonesia. Jakarta. Riset Kesehatan Dasar, Badan Penelitian dan Pengembangan Kesehatan Kementerian Kesehatan Indonesia, Kementerian Kesehatan RI, Jakarta (Indonesian). 2013.
Krummel, D. Medical Nutrition Therapy in Cardiovascular Disease. In: L. Kathleen Mahan dan Sylvia Escott Stump, Krause's. Food Nutrition and Diet Therapy. WB Saunders Company; USA: 2004.
Orford JL, Selwyn AP. Atherosclerosis. Instant Access to the Mind of Medicine, Medicine, Department of Internal Medicine, Brigham a Women's Hospital, Harvard Medical School. 2005.
Durst RW, Wrolstad RE. Unit F1.2: Characterization and Measurement of Anthocyanins by UV–visible Spectroscopy. In: Wrolstad RE (eds). Handbook of analytical food chemistry. New York: John Wiley; 2005. 33–45
Craig WJ. Vegetarian phytochemicals, guardians of our health, a continuing education article. 2002. http://www.andrews.edu/NUFS/phyto.html>.
Jusuf M, Rahayuningsih SA, Ginting E. Purple Sweet Potatoes. Research News and Agricultural Development. 2008;30(4):13-14
Ginting, E. (2011). Potensi Ekstrak Ubijalae Ungu sebagai Bahan Pewarna Alami Sirup. Prosiding Seminar Hasil Penelitian Tanaman Aneka Kacang dan Umbi, 755-767: Balai Penelitian Tanaman Kacang-kacangan dan Umbi-umbian.
Hwang YP, Jae HC, Hyo JY, Eun HH, Hyung GK, Jin YK, Bong HP, Tilak K, Jun MC, Young CC, Hye GJ. Purple Sweet Potato Anthocyanin Attenuate Hepatic Lipid Accumulation, Through Activating Adenosine Monophosphate-Activated Protein Konase In Human HpG2 cell and obese mice. Nutrition Research. 2011;(24):93-99.
Qin Y, Xia M, Ma J, Hao TY, Liu J, Mou YH, Cao L, Ling WH. Anthocyanin Supplementation Improves Serum LDL- and HDL-Cholesterol Concentrations Associated with The Inhibition of Cholesteryl Ester Transfer Protein in Dislipidemic Subject. The American Journal of Clinical Nutrition. 2009;90(3):485-492.
Copyright (c) 2022 Meddy Setiawan, Dzikrulloh Abdi, S Khanza Zatalini
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
1. The journal allows the author to hold the copyright of the article without restrictions.
2. The journal allows the author(s) to retain publishing rights without restrictions
3. The legal formal aspect of journal publication accessibility refers to Creative Commons Attribution Share-Alike (CC BY-SA).
