Berkala Ilmiah Kimia Farmasi

Formulation of Cream Containing Ethanolic Extract of Mugwort (Artemisia vulgaris L.) and Its Antifungal Activity Testing on Candida albicans ATCC 10231

Yaya Sulthon Aziz, Naila Matsna Assyifa, Amalia Rahma Pratiwi, Siska Tri Wahyuni — Sat, 30 Nov 2024 00:00:00 +0700

According to the people of the Tengger Tribe for generations, a Mugwort plant (Artemisia vulgaris L.) was believed to be useful as a treatment for fungal infections. Based on research reports, the Mugwort plant (Artemisia vulgaris L.) contained bioactive compounds such as flavonoids, tannins, saponins, steroids, and alkaloids. These active compounds had activity as an antifungal. This study aimed to formulate, evaluate, and test the activity of a cream preparation with type m/a ethanol extract of Mugwort (Artemisia vulgaris L.) in inhibiting the growth of the fungus Candida albicans ATCC 10231. This type of research was laboratory experimental research. Samples were taken by simple random sampling to test the inhibition of Candida albicans ATCC 10231. The results of the physical quality test of Mugwort leaf extract (Artemisia vulgaris L.) cream from the 4 formulation with test parameters including organoleptic, pH, spreadability, adhesion, and viscosity test, were in accordance with the established quality standards. The results of the physical evaluation of the antifungal cream showed organoleptic properties, homogeneity, pH 6, spreadability test F1 5.2, FII 5.1, FIII 5.3, and FIV 5.4 cm, FI adhesion test 5.3, FII 5.3, FIII 5.4, and FIV 5.5 seconds. Meanwhile, in the viscosity test the results were FI 24,606, FII 30,836, FIII 40,198 cP, and FIV 38,695 cP. The inhibition test results were analyzed by calculating the average for each concentration, performed three times. The results showed that the ethanol extract of Mugwort leaf (Artemisia vulgaris L.) cream had antifungal effectiveness with an average value of 8.6 mm at a concentration of 2.5% (moderate category), 10.3 mm at a concentration of 5% (medium category), 11 mm at a concentration of 10% (strong category) and 12 mm at a concentration of 20% (strong category). The study concluded that the ethanol extract of Mugwort Leaf (Artemisia vulgaris L.) cream was effective in inhibiting the growth of Candida albicans ATCC 10231.

Keywords: Mugwort (Artemisisa Vulgaris L), Antifungal, Candida Albicans ATCC 10231

Optimization of Health Product Formulas containing Lemongrass Essential Oil (Cymbopogon citratus (DC.) Stapf): Development of Bar Soap, Aromatherapy Candle, and Carbolic Floor Clearner

Sun, 30 Jun 2024 00:00:00 +0700

Lemongrass essential oil (Cymbopogon citratus (DC.) Stapf) had many benefits, including antibacterial, antifungal, anti-inflammatory properties, and effectiveness as a repellent against Aedes aegypti mosquitoes. These oils were processed into various household products, such as bar soap, carbolic floor cleaner, and aromatherapy candles. This research aimed to manufacture bar soap, carbolic floor cleaner, and aromatherapy candles on a laboratory scale that homemakers could replicate. Bar soap was made using VCO, palm oil, and olive oil, which were mixed with an NaOH solution. Aromatherapy candles were produced using solid paraffin that was melted and mixed with lemongrass essential oil, while carbolic floor cleaner was made using a combination of two phases: the oil phase, which used texapon, and the water phase, which used hexylene glycol. The results showed that the products had adequate physical characteristics and economic value. In addition to being beneficial for health, the products could also be marketed to increase family income.

Keywords: Lemongrass Essential Oil, Health Products Formulation, Bar Soap, Aromatherapy Candles, Carbolic Floor Clearner

Clay Mask Preparation Combination of Papaya Leaf Extract (Carica papaya L.) and Sousop Leaf (Annona muricata L.)

Ery Nourika Alfiraza, Endang Istriningsih, Nadiyya Rizka Maulana — Sun, 30 Jun 2024 00:00:00 +0700

One type of cosmetic product used to care for facial skin is a mask. Clay masks are masks that contain mineral materials derived from clay, especially kaolin and bentonite. The purpose of this study was to determine the difference in concentration in formula F0 (0:0) FI(2:6), formula FII (4:4), and formula FIII (6:2) with a combination of papaya leaf extract and soursop leaf in clay mask preparations. This study uses an experimental approach, which starts with preparing a mask preparation and then evaluating the mask preparation. The results of One Way Anova's data analysis show that the sig value is 0.000 < 0.05, which means that H₀ is rejected. The results of organoleptic, pH, homogeneity, dispersion, adhesion, dry time, viscosity, irritation, and stability showed that all concentrations of formula F0, FI, FII, and FIII met the requirements. The results of all concentration differences in F0, FI, FII, and FIII showed that the combination of papaya leaf extract and soursop leaf extract could be made in clay mask preparations.

Keywords: Papaya Leaves, Soursop Leaves, Mineral Clay

Antioxidant Activity of Lip Balm Ethanol Extract Keji Beling Leaves (Strobilanthes crispus Blume) using The DPPH (2,2-diphenyl-1-picryhydrazyl) Method

Sinta Nuraesa, Susanti Susanti, Ali Nofriyaldi — Sun, 30 Jun 2024 00:00:00 +0700

Keji beling leaves contained compounds that have the potential to act as moisturizers, namely flavonoids with catechins that function as high antioxidants in preventing free radicals. Keji beling leaf extract can be used as a preparation to overcome dry lips, namely as a moisturizer in the form of lip balm preparations. The purpose of this study was to formulate a lip balm from ethanol extract of keji beling leaves, and to determine the antioxidant activity. This research method included 70% ethanol extract of keji beling leaves with the maceration method and antioxidant activity, namely the DPPH method (2,2-diphenyl-1-picrylhydrazyl) with Vitamin C as a positive control (comparator). The results showed that formula 3 lip balm preparations with 70% ethanol extract of keji beling leaves had antioxidant activity with an IC₅₀ value of 3.12 ppm in the very strong category.

Keywords: Antioxidant, Keji Beling Leaves (Strobilanthes crispus Blume), DPPH (2,2-diphenyl-1-picrylhydrazyl),

Lip Balm

Antioxidants Activity of Temurui (Murraya koenigii L Spreng) Leaves Extract and Their Active Compounds

Sun, 30 Jun 2024 00:00:00 +0700

People have historically utilized temurui leaves to treat diabetes and diarrhoea. This study aimed to determine the temurui leaf extract's antioxidant properties. Antioxidant activity was examined on methanol, ethyl acetate, and methanol extracts of temurui leaves using the FRAP (Ferric Reducing Antioxidant Power) and DPPH (2,2-diphenyl-1-picryhydrazyl) techniques spectrophotometrically at wavelengths of 720 and 517 nm, respectively. Antioxidant activity parameters were measured based on the IC₅₀ value. The results showed that methanol, ethyl acetate, and n-hexane extracts of temurui leaves had relatively weak antioxidant activity with IC₅₀ values of 179,745±4,26; 189,730±15,403; and 282,244±12,297 mg/L (DPPH method) and 287,305±19,054; 344,809±63,907; 505,065±32,567 mg/L (FRAP method), respectively. Therefore, methanol extract of temurui leaves has the potential as a better antioxidant than n-hexane and ethyl acetate extracts. The UPLC-QTof-MS/MS analysis indicated that the methanol extract of these leaves consists of 13 chemicals such as phenolic, steroid, and alkaloid groups which are closely related to its antioxidant properties.

Keywords: Murraya koenigii L spreng, Antioxidant, DPPH, FRAP, UPLC-MS