Akantosis Nigrikans pada Anak

Kartika Kemala, Retno Danarti

= http://dx.doi.org/10.20473/bikkk.V31.1.2019.61-70
Abstract views = 58 times | views = 62 times

Abstract


Latar Belakang: Akantosis nigrikans (AN) merupakan kelainan kulit yang ditandai dengan patch atau plak hiperpigmentasi dengan permukaan kasar dan struktur seperti beludru yang biasanya terdistribusi simetris pada daerah lipatan. Selain merupakan tanda klinis yang kuat adanya resistensi insulin dan sindrom metabolik, AN berhubungan pula dengan keganasan, penggunaan obat-obatan, serta dapat menjadi salah satu manifestasi yang menyertai sindrom. Tujuan: Menjelaskan patofisiologi, manifestasi klinis, diagnosis, serta klasifikasi AN. Telaah Kepustakaan: Klasifikasi AN yang ada seringkali tidak konsisten, tumpang tindih dan membingungkan. Hal terpenting dari diagnosis AN adalah membedakan apakah lesi yang ada termasuk ke dalam lesi jinak atau ganas, yang akan memengaruhi pemberian terapi dan prognosis penyakit. Terapi AN tergantung dari penyebab yang mendasari dan ditujukan untuk memperbaiki penampilan dari segi kosmetik. Simpulan: Kewaspadaan klinisi harus ditingkatkan pada kasus AN untuk memberikan penatalaksanaan yang tepat sejak dini.


Keywords


Akantosis nigrikans; resistensi insulin; sindrom metabolik;

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References


Kutlubay Z, Engin B, Bairamov O, Tuzun Y. Acanthosis nigricans: a fold (intertriginous) dermatosis. Clin Dermatol 2015;33(4):466-70.

Karadag AS, You Y, Danarti R, Al-Khuzae S, Chen WC. Acanthosis nigricans and the metabolic syndrome. Clin Dermatol 2018;36(1):48-53.

Ng HY. Acanthosis nigricans in obese adolescents: Prevalence, impact, and management challenges. Adolesc Health Med Ther 2017;8:1-10.

Santoro N, Amato A, Grandone A, Brienza C, Savarese P, Tartaglione N, et al. Predicting metabolic syndrome in obese children and adolescents: look, measure and ask. Obes Facts 2013;6(1):48-56.

Koh YK, Lee JH, Kim EY, Moon KR. Acanthosis nigricans as a clinical predictor of insulin resistance in obese children. Pediatr Gastroenterol Hepatol Nutr 2016;19(4):251-8.

Ng HY, Young JHM, Huen KF, Chan LTW. Acanthosis nigricans in obese Chinese children. Hong Kong Med J 2014;20(4):290-6.

Phiske MM. An approach to acanthosis nigricans. Indian Dermatol Online J 2014;5(3):239-49.

Zhang N, Qian Y, Feng AP. Acanthosis nigricans, tripe palms, and sign of Leser-Trelat in a patient with gastric adenocarcinoma: Case report and literature review in China. Int J Dermatol 2015;54(3):338-42.

Curth HO. Classification of acanthosis nigricans. Int J Dermatol 1976;15(8):592-3.

Hernandez-Perez E. On the classification of acanthosis nigricans. Int J Dermatol 1984;23(9):605-6.

Sinha S, Schwartz RA. Juvenile acanthosis nigricans. J Am Acad Dermatol 2007;57(3):502-8.

Lee HC, Ker KJ, Chong WS. Oral malignant acanthosis nigricans and tripe palms associated with renal urothelial carcinoma. JAMA Dermatol 2015;151(12):1381-3.

Ahmad S, Mahmoudi H, Naeem M, Betz RC. Autosomal recessive isolated familial acanthosis nigricans in a Pakistani family due to a homozygous mutation in the insulin receptor gene. Br J Dermatol 2013;169(2):476-8.

Berk DR, Spector EB, Bayliss SJ. Familial acanthosis nigricans due to K650T FGFR3 mutation. Arch Dermatol 2007;143(9):1153-6.

Fukuchi K, Tatsuno K, Matsushita K, Kubo A, Ito T, Tokura Y. Familial acanthosis nigricans with p.K650T FGFR3 mutation. J Dermatol 2018;45(2):207-10.

Cossiez Cacard MA, Coulombe J, Bernard P, Kaci N, Bressieux JM, Souchon PF, et al. Familial hypochondroplasia and acanthosis nigricans with FGFR3 K650T mutation. J Eur Acad Dermatol Venereol 2016;30(5):897-8.

Bhagyanathan M, Dhayanithy D, Parambath VA, Bijayraj R. Acanthosis nigricans: A screening test for insulin resistance - An important risk factor for diabetes mellitus type-2. J Family Med Prim Care 2017;6(1):43-6.

Slyper AH, Kashmer L, Huang WM, Reem Y. Acanthosis nigricans, vitamin D, and insulin resistance in obese children and adolescents. J Pediatr Endocrinol Metab 2014;27(11-12):1107-11.

Verma S, Vasani R, Joshi R, Phiske M, Punjabi P, Toprani T. A descriptive study of facial acanthosis nigricans and its association with body mass index, waist circumference and insulin resistance using HOMA2 IR. Indian Dermatol Online J 2016;7(6):498-503.

Panda S, Das A, Lahiri K, Chaterjee M, Padhi T, Rathi S, et al. Facial acanthosis nigricans: A morphological marker of metabolic syndrome. Indian J Dermatol 2017;62(6):591-7.

Dedjan AH, Chadi A, El Aziz S, Farouqi A. Hyperandrogenism-insulin resistance-acanthosis nigricans syndrome. Case Rep Endocrinol 2015;2015:193097.

Zelada H, Gammara D, Arbanil H, Manrique H. Type B insulin resistance in Peru. Am J Med Sci 2017;353(3):258-62.

Sinnarajah K, Dayasiri MBKC, Dissanayake NDW, Kudagammana ST, Jayaweera AHHM. Rabson Mendenhall syndrome caused by a novel missense mutation. Int J Pediatr Endocrinol 2016;2016:21.

Nijim Y, Awni Y, Adawi A, Bowirrat A. Classic case report of Donohue syndrome (Leprechaunism; OMIM *246200): The impact of consanguineous mating. Medicine (Baltimore) 2016;95(6):e2710.

Giri D, Alsaffar H, Ramakrishnan R. Acanthosis nigricans and its response to metformin. Pediatr Dermatol 2017;34(5):e281-2.


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