EFFECT OF BLACK GRAPE EXTRACT ON CD4+ and CD8+ EXPRESSION IN MICE INFECTED WITH Salmonella typhimurium

Salmonelosis is a disease caused by the Salmonella sp. that causes a decrease in CD4⁺ expression. Black grape can boost the immune system through CD4⁺/CD8⁺ proliferation. The purpose of this study was to evaluate the activity of black grape extract to CD4⁺ and CD8⁺ expression in mice infected with Salmonella typhimurium. Research method is extract of black grapes, Salmonella typhimurium 10⁸ infection, bacterial evaluation, extract therapy, flowcytometery examination, and 95% Anova test. The results of Anova test showed that the expression of CD4⁺ and CD8⁺ is not different. Biologically, an increase in CD4⁺ and CD8⁺ expression at doses of 100 mg/KgBB. A decrease in CD4⁺ and CD8⁺ expression at doses of 200 mg/KgBB and 400 mg/KgBB. Conclusion, biologically, black grape extract can increase the expression of CD4⁺ and CD8⁺ at low doses, as well as may decrease the expression of CD4⁺ and CD8⁺ at moderate to high doses.