The potency of propolis extract as anti-inflammatory agent for stimulation of reparative dentin formation
Downloads
Background: As an effort to treat a deep caries lesion with a diagnosis of reversible pulpitis, one of the treatment options is pulp capping. For decades, calcium hydroxide has been considered the most acceptable pulp capping material and has been routinely used in dental practice, but it also has some weakness. To overcome that, alternative materials are needed that can provide a better effect. Recently, a lot of research has been done using natural ingredients, including Propolis. Propolis has been known to have strong antimicrobial and anti inflammatory properties. Therefore, it is necessary to conduct a deeper study regarding the potency of propolis extract as an anti inflammatory agent for the stimulation of reparative dentin formation so that it can be considered to be used as a pulp capping material.
Objective: The aim of this literature review is to highlight the potency of propolis extract as anti inflammatory agent in the natural stimulation of reparative dentin formation.
Methods: The search strategy consist of an electronic research using databases such as PubMed, Google Scholar, Science Direct, dan Springer Link for studies published from 2003 to 2021 regarding the potency of propolis extract as anti inflammatory agent for stimulation of reparative dentin formation, including review articles and research articles.
Results: Propolis and its constituents have been proven to be used as a potent natural anti inflammatory, it also considered to have the ability to promote reparative dentin formation. However, there are some literatures stated that reparative dentin does not form with the application of propolis, and the causes may vary.
Conclusion: Propolis extract has a potency as an anti inflammatory agent in dental pulp inflammation by inhibiting TNFα expression, and increasing TGF-β1 expression, as well as its potency in stimulating the formation of reparative dentin. Based on this review, further studies are needed.
da Rosa WLO, Cocco AR, Silva TM, Mesquita LC, Galarc AD, Silva AF, Piva E. Current trends and future perspectives of dental pulp capping materials: A systematic review. J Biomed Mater Res Part B. 2017;1-11.
Garg N, Garg A. Textbook of Endodontics. 3rd ed. Jaypee Brothers Medical Publishers (P) Ltd; 2014.
Dean JA. Treatment of deep caries, vital pulp exposure, and pulpless teeth. In: McDonald and Avery's Dentistry for the Child and Adolescent. 10th ed. Saunders Elsevier Inc; 2015. Pp: 221–242.
Sahar H, Dalia E. The Adverse Effects of Nano bond Adhesive Systems Used as Direct Pulp Capping Materials. Eur J Dent Med. 2012;4:14-25.
Janebodin K, Horst OV, Osathanon T. Dental pulp response to pulp capping materials and bioactive molecules. CU Dent J. 2010;33:229-48.
Bogen G, Kim JS, Backland LK. Direct pulp capping with mineral trioxide aggregate. J Am Dent Assoc. 2008;139:305-15.
Siregar HC, Fuah AM, Octavianty Y. Propolis; Madu Multikhasiat. Penebar Swadaya Grup; 2011.
Banskota AH, Teruka Y, Adnyana IK, Midosikawa M, Matsushige K, Kadota S. Anti-inflammatory effect of propolis through inhibition of nitric oxide production on carrageen-induced mouse paw edema. Phytomedicine. 2001;8:16–23.
Nagaoka T, Banskota AH, Tezuka Y, Midorikawa K, Matsushige K, Kadota S. Caffeic acid phenethyl ester (CAPE) analogues: Potent nitric oxide inhibitors from the Netherlands propolis. Biol Pharm Bull. 2003;26:487–91.
Jain S, Rair R, Sharma V, Batra M. Propolis in oral health: A natural remedy. World J Pharm Sci. 2014;2(1):90-4.
Agrawal N, Gupta ND, Tewari RK, Garg AK, Singh R. Oral health from hive: Potential uses of propolis in dentistry. Biolife. 2014;2:1110-6.
Sabir A. Respons pulpa gigi tikus terhadap propolis sebagai bahan kaping pulpa langsung. IJD Edisi Khusus KPPIKG. 2006;14:57-61.
Torabinejad M, Walton RE. Endodontics Principles and Practice. 5th ed. St. Louis: Saunders Elseviers Inc; 2012.
Banerjee R, Becker D, Dickman M, Gladyshev V, Ragsdale S. Redox Biochemistry. Wiley Interscience. A John Wiley & Sons, Inc; 2008.
Parolia A, Kundabala M, Rao NN, Acharya SR, Agrawal P, Mohan M, Thomas M. A comparative histological analysis of human pulp following direct pulp capping with Propolis, mineral trioxide aggregate and Dycal. Aust Dent J. 2010;55:59-64.
Sabir A. Indonesian propolis suppressed the expression of COX-2 in inflamed rat dental pulp in direct capping treatment. J Dentomaxillofac Sci. 2019;4(2):109.
Yuanita T. Propolis pada imunopatobiologi penyembuhan periodontitis apikalis kronis. Surabaya: Airlangga University Press; 2017.
Merlini R, Parolia A, Pau A, Amalraj FD. The role of propolis in inflammation and orofacial pain: A review. Ethnopharmacology. 2013;149:651-64.
Sabir A. Respons inflamasi pada pulpa gigi tikus setelah aplikasi ekstrak etanol propolis (EEP). Dent J (Majalah Kedokteran Gigi). 2005;38(2):77–83.
Sankar G. Handbook of Transcription Factor NF-kappaB. CRC Press. Taylor & Francis Group; 2020.
Wang LC, Chu KH, Liang YC, Lin YL, Chiang BL. Caffeic acid phenethyl ester inhibits nuclear factor-kappaB and protein kinase B signalling pathways and induces caspase-3 expression in primary human CD4+ T cells. Clin Exp Immunol. 2010;160(2):223-32.
Wang L, Lin Y, Liang Y, Yang Y, Lee J, Yu H, Wu W, Chiang B. The effect of caffeic acid phenethyl ester on the functions of human monocyte-derived dendritic cells. BMC Immunol. 2009;10:39.
Búfalo MC, Ferreira I, Costa G, Francisco V, Liberal J, Cruz MT, Lopes MC, Batista MT, Sforcin JM. Propolis and its constituent caffeic acid suppress LPS-stimulated pro-inflammatory response by blocking NF-κB and MAPK activation in macrophages. J Ethnopharmacology. 2013;149(1):84-92.
Rohman MS, Rastini EK, Sarbini D, Titi AW, Widodo, Sargowo D. Inhibition of NFκB activation by CAPE (Caffeic Acid Phenethyl Ester), An Active Component of Honeybee Hives, in OXLDL- Treated HUVEC'S (Human Umbilical Vein Endothelial Cells). Jurnal Kedokteran Brawijaya. 2006;21(1):1-5.
Rahayu RP, Pribadi N, Widjiastuti I, Nugrahani NA. Combinations of propolis and Ca(OH)2 in dental pulp capping treatment for the stimulation of reparative dentin formation in a rat model. F1000Research. 2020;9:308.
Chandrasekhar H, Sharma S. Efficient Agents for Pulp Protection: A Review. J Pharm Sci & Res. 2016;8(11):1308-11.
Ahangari Z, Nasari M, Jalili M, Mansouri Y, Mashhadiabbas F, Torkaman A. Effect of Propolis on Dentin Regeneration and the Potential Role of Dental Pulp Stem Cell in Guinea Pigs. Cell J. 2012;13(4):223-8.
Sabir A. Prospect of using propolis in conservative dentistry and endodontic treatment (Basic research vs clinical application). Dentika Dent J. 2014;18(2):185-9.
Saleh R, Nagi S, Ezzat M, Abd El-Alim S, Zaazou M, Abu-seida A, Ibrahim M. In-Vivo Assessment of Dentin bridge Formation after Using MTA and Experimental Propolis Paste as Direct Pulp Capping Material. Res J Pharm Biol Chem Sci. 2016;7:1244-50.
This work is licensed under a Creative Commons Attribution 4.0 International License.
CDJ by Unair is licensed under a Creative Commons Attribution 4.0 International License.
1. The journal allows the author to hold the copyright of the article without restrictions.
2. The journal allows the author(s) to retain publishing rights without restrictions