The synergistic role of the immune system and stem cells in dental tissue regeneration
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Background: Dental conservation focuses on maintaining natural teeth structure, function, and aesthetics using various techniques. Recent developments in regenerative dentistry highlight the immune system's and stem cells' crucial roles in regenerating dental tissues. The immune system is key in preserving oral health and supporting healing after treatment. Incorporating stem cell therapy presents a promising strategy for restoring damaged tissues, potentially enhancing the effectiveness of dental conservation. Purpose: This review explores the growing potential of immune system modulation and stem cell therapy in promoting tissue regeneration and optimizing clinical outcomes in dental conservation. It aims to summarize recent research while examining this evolving field's benefits, challenges, and future prospects. Reviews: Research indicates that the immune system's inflammatory response plays a dual role as it is crucial for wound healing but can lead to tissue damage if not regulated. Recent studies emphasize the importance of balancing pro-inflammatory and anti-inflammatory mechanisms to optimize tissue regeneration. Stem cells show promising potential in regenerating dentin, pulp, and periodontal tissues. Integrating stem cell therapy with immune modulation may further enhance regenerative outcomes. However, translating these approaches into clinical practice remains challenging due to concerns regarding safety, effectiveness, and ethical considerations. Conclusion: Regulating the immune system and integrating stem cell therapy offer promising advancements in dental conservation. Effectively utilizing these biological mechanisms can enhance tissue regeneration and improve treatment success. Future studies should aim to refine protocols, ensure long-term safety, and overcome practical barriers to fully incorporate these innovations into everyday clinical practice.
Abnave P, Ghigo E. Role of the immune system in regeneration and its dynamic interplay with adult stem cells. Semin Cell Dev Biol. 2019; 87: 160–168.
Potdar PD, Jethmalani YD. Human dental pulp stem cells: Applications in future regenerative medicine. World J Stem Cells. 2015; 7(5): 839.
Sarfi S, Azaryan E, Naseri M. Immune system of dental pulp in inflamed and normal tissue. DNA Cell Biol. 2024; 43(8): 369-386.
Bansal R, Jain A. Current overview on dental stem cells applications in regenerative dentistry. J Nat Sci Biol Med. 2015; 6(1): 29.
Goriuc A, Foia L, Cojocaru K, Diaconu-Popa D, Sandu D, Luchian I. The role and involvement of stem cells in periodontology. Biomedicines. 2023; 11(2): 387.
Trounson A, McDonald C. Stem cell therapies in clinical trials: progress and challenges. Cell Stem Cell. 2015; 17(1): 11-22.
Aurora AB, Olson EN. Immune modulation of stem cells and regeneration. Cell Stem Cell. 2014; 15(1): 14-25.
Costalonga M, Herzberg MC. The oral microbiome and the immunobiology of periodontal disease and caries. Immunol letters. 2014; 162(2): 22-38.
Song N, Scholtemeijer M, Shah K. Mesenchymal stem cell immunomodulation: mechanisms and therapeutic potential. Trends Pharmacol Sci. 2020; 41(9): 653-64.
Prasetyo EP, Juniarti DE, Kuntjoro M, Hendrijantini N, Putra AA, Oktaria W, Hutapea ZFRD, Tjendronegoro E. Mesenchymal stem cells from human umbilical cord decrease inflammation and increase vascularization of induced apical periodontitis model in diabetes mellitus rats. J Appl Oral Sci. 2024; 32: e20240225.
Valenti MT, Serena M, Dalle Carbonare L, Zipeto D. CRISPR/Cas system: An emerging technology in stem cell research. World J Stem Cells. 2019; 11(11): 937.
Kuntjoro M, Prasetyo EP, Cahyani F, Kamadjaja MJK, Hendrijantini N, Laksono H, Rahmania PN, Ariestania V, Nugraha AP, Ihsan IS, Dinaryanti A, Rantam FA. Lipopolysaccharide’s cytotoxicity on human umbilical cord mesenchymal stem cells. Pesqui Bras Odontopediatria Clin Integr. 2020; 20: e0048.
Beck JD, Papapanou PN, Philips KH, Offenbacher S. Periodontal medicine: 100 years of progress. J Dent Res. 2019; 98(10): 1053-1062.
Hendrijantini N, Kuntjoro M, Agustono B, Ari MD, Kurdi A, Mundiratri K, Prasetyo EP, Hong G. Bone formation and mineralization around the implant in osteoporotic animal models enhanced by mesenchymal stem cells. Dent J. 2024; 57(2): 91-96.
Costa LA, Eiro N, Vaca A, Vizoso FJ. Towards a new concept of regenerative endodontics based on mesenchymal stem cell-derived secretomes products. Bioengineering. 2022; 10(1): 4.
Luzuriaga J, Polo Y, Pastor-Alonso O, Pardo-Rodríguez B, Larrañaga A, Unda F, Sarasua JR, Pineda JR, Ibarretxe G. Advances and perspectives in dental pulp stem cell based neuroregeneration therapies. Int J Mol Sci. 2021; 22(7): 3546.
Li W, Xiang Z, Yu W, Huang X, Jiang Q, Abumansour A, Yang Y, Chen C. Natural compounds and mesenchymal stem cells: implications for inflammatory-impaired tissue regeneration. Stem Cell Res Ther. 2024; 15(1): 34.
D’Ambrosio F. Periodontal and peri-implant diagnosis: current evidence and future directions. Diagnostics. 2024; 14(3): 256.
Prasetyo EP, Saravanan P, Kharisna D, Wijanarko CI, Kuntjoro M, Hendrijantini N, Tjendronegoro E. Umbilical cord mesenchymal stem cells improve bone regeneration in diabetes mellitus animal model with apical periodontitis. J Oral Biol Craniofac Res. 2025; 15(1): 16-21.
Nakashima M, Iohara K. Mobilized dental pulp stem cells for pulp regeneration: initiation of clinical trial. J Endod. 2014; 40(4): S26-32.
Ramadan DE, Hariyani N, Indrawati R, Ridwan RD, Diyatri I. Cytokines and chemokines in periodontitis. Eur J Dent. 2020; 14(03): 483-495.
Chen R, Hao Z, Wang Y, Zhu H, Hu Y, Chen T, Zhang P, Li J. Mesenchymal stem cell–immune cell interaction and related modulations for bone tissue engineering. Stem Cells Int. 2022; 2022(1): 7153584.
Ariestania V, Hendrijantini N, Prahasanti C, Prasetyo E, Kuntjoro M, Sari RP, Maharani AD. Cytotoxicity of HA-TCP scaffold on human umbilical cord mesenchymal stem cells using MTT assay. Int J Integ Eng. 2022; 14(2): 80-85.
Li F, Wang X, Shi J, Wu S, Xing W, He Y. Anti-inflammatory effect of dental pulp stem cells. Front Immunol. 2023; 14: 1284868.
Nikoloudaki G. Functions of matricellular proteins in dental tissues and their emerging roles in orofacial tissue development, maintenance, and disease. Int J Mol Sci. 2021; 22(12): 6626.
Prasetyo EP, Wahjuningrum DA, Sampoerno G, Sukandar W, Sharizal SSB, Paidal N, Amriel MF, Gunawan NE, Suardita K, Tjendronegoro E. A review of tissue engineering in regenerative endodontic treatment. Conserv Dent J. 2024; 14(1): 1–5.
Smojver I, Katalinić I, Bjelica R, Gabrić D, Matišić V, Molnar V, Primorac D. Mesenchymal stem cells based treatment in dental medicine: a narrative review. Int J Mol Sci. 2022; 23(3): 1662.
Fernandes TL, Cortez de SantAnna JP, Frisene I, Gazarini JP, Gomes Pinheiro CC, Gomoll AH, Lattermann C, Hernandez AJ, Franco Bueno D. Systematic review of human dental pulp stem cells for cartilage regeneration. Tissue Engineering Part B: Reviews. 2020; 26(1): 1-2.
Rahnama-Hezavah M, Mertowska P, Mertowski S, Skiba J, Krawiec K, Łobacz M, Grywalska E. How can imbalance in oral microbiota and immune response lead to dental implant problems?. Int J Mol Sci. 2023; 24(24): 17620.
Thalakiriyawa DS, Dissanayaka WL. Advances in regenerative dentistry approaches: An update. Int Dent J. 2024; 74(1): 25-34.
Woo HN, Cho YJ, Tarafder S, Lee CH. The recent advances in scaffolds for integrated periodontal regeneration. Bioactive materials. 2021; 6(10): 3328-3342.
Poblano-Pérez LI, Castro-Manrreza ME, González-Alva P, Fajardo-Orduña GR, Montesinos JJ. Mesenchymal stromal cells derived from dental tissues: immunomodulatory properties and clinical potential. Int J Mol Sci. 2024; 25(4): 1986.
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