Hepatocellular Carcinoma with Inferior Vena Cava Thrombus in a Child
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Hepatocellular carcinoma (HCC) in children is the second common malignant liver tumor after hepatoblastoma. Chronic hepatitis B virus (HBV) infection causes most hepatocellular cancer worldwide. Metastases to the inferior vena cava (IVC) and right atrium (RA) tumor thrombi are even less common. We reported a case of a 13-year-8-month-old girl with HCC and IVC involvement. Vascular invasion predicts poor overall survival in HCC patients. Patients with HCC involving the IVC had a higher risk of sudden mortality and a poor treatment outcome. It is difficult to treat, and no standard therapy has been established. This case report aimed to describe HCC with IVC involvement. This is a rare disease with a poor prognosis, therefore it is important to detect and manage early.
Aly R, Gupta S, Gupta R, Jorge VM, Ebraheem A. 2020. Hepatocellular carcinoma presenting with inferior vena cava tumor thrombus extending to the right atrium: A Case Report. Cureus 12(7): e9421. doi:10.7759/cureus.9421.
Czauderna P, Mackinlay G, Perilongo G, Brown J, Shafforf E, Aronson D, Pritchard J, Chapchap P, Keeling J, Plaschkes J, Otte JB. 2002. Hepatocellular carcinoma in children: results of the first prospective study of the International Society of Pediatric Oncology group. J Clin Oncol 20(12):2798-804. doi: 10.1200/JCO.2002.06.102.
GÅ‚owska-Ciemny J, Szymanski M, Kuszerska A, Rzepka R, von Kaisenberg CS, Kocylowski R. 2023. Role of Alpha-Fetoprotein (AFP) in diagnosing childhood cancers and genetic-related chronic diseases. Cancers (Basel) 15(17):4302. https://doi.org/10.3390/cancers15174302.
Huang Y, Zhang Z, Zhou Y, Yang J, Hu K, Wang Z. 2019. Should we apply sorafenib in hepatocellular carcinoma patients with microvascular invasion after curative hepatectomy?. Onco Targets and Therapy 12:541–548. https://doi.org/10.2147/OTT.S187357.Kelly, D. et al. (2015) ‘Hepatocellular Carcinoma in Children', Clinics in Liver Disease, 19(2), pp. 433–447. Available at: https://doi.org/10.1016/j.cld.2015.01.010.
Khanna R and Verma SK. 2018. Pediatric hepatocellular carcinoma. World Journal of Gastroenterology 24(35): 3980–3999. https://doi.org/10.3748/wjg.v24.i35.3980.
Luo X, Zhang B, Dong S, Zhang B, Chen X. 2015. Hepatocellular Carcinoma With Tumor Thrombus Occupying the Right Atrium and Portal Vein: A Case Report and Literature Review. Medicine (Baltimore) 94(34):e1049. https://doi.org/10.1097/MD.0000000000001049.
McAree B, O'Donnell M, Fitzmaurice GJ, Reid JA, Spence RAJ, Lee B. 2013. Inferior vena cava thrombosis: A review of current practice. Vascular Medicine 18(1):32–43. https://doi.org/10.1177/1358863X1247196.
Quencer KB, Friedman T, Sheth R, Oklu R. 2017. Tumor thrombus: incidence, imaging, prognosis and treatment. Cardiovascular Diagnosis and Therapy 7(Suppl 3):S165–S177. https://doi.org/10.21037/cdt.2017.09.16.
Takano T, Tajiri H, Hosono S, Inui A, Murakami J, Ushijima K, Miyoshi Y, Etani Y, Abukawa D, Suzuki M, Brooks S. 2017. Natural history of chronic hepatitis B virus infection in children in Japan: a comparison of mother-to-child transmission with horizontal transmission. Journal of Gastroenterology 52(9):1041–1050. https://doi.org/10.1007/s00535-017-1315-4.
Wang J, Mao Y, Liu Y, Chen Z, Chen M, Lao X, Li S. 2017. Hepatocellular carcinoma in children and adolescents: clinical characteristics and treatment. Journal of Gastrointestinal Surgery 21(7):1128–1135. https://doi.org/10.1007/s11605-017-3420-3.
Zhang ZY, Zhang EL, Zhang BX, Zhang W. 2021. Surgery for hepatocellular carcinoma with tumor thrombosis in inferior vena cava: A case report. World Journal of Clinical Cases 9(36):11495–11503. https://doi.org/10.12998/wjcc.v9.i36.11495.
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