Current Internal Medicine Research and Practice Surabaya Journal 2024-01-31T00:00:00+07:00 Prof. Dr. Usman Hadi, dr., Sp.PD, K-PTI., FINASIM Open Journal Systems <p><strong>Current Internal Medicine Research and Practice Surabaya Journal</strong> (CIMRJ) <a href="">e-ISSN: 2721-544X</a> is published by the Faculty of Medicine, Universitas Airlangga in collaboration with <a href="" target="_blank" rel="noopener">The Indonesian Society of Internal Medicine (PAPDI) branch of Surabaya</a>.</p> <p><strong>Current Internal Medicine Research and Practice Surabaya Journal</strong> classify the articles into Original Articles, Case Report, and Review Articles. It is published two times a year in January and August. The scope of this journal includes allergy, endocrinology, gastroenterology, geriatrics, hematology, hepatology, nephrology, rheumatology, and tropical infection.</p> Effect of High-Calorie Diet and Moderate-Intensity Physical Exercise on Gastric Histopathological Features of Mice 2024-01-30T15:19:47+07:00 Ramadhani Rizki Zamzam Irfiansyah Irwadi Alphania Rahniayu <p><strong>Introduction:</strong> Habit of consuming excess calories and sedentary lifestyle can cause oxidative stress which is known to be involved in the pathophysiological process of various diseases including diseases of the gastrointestinal mucosa. Increased Reactive Oxygen Species (ROS) due to a high-calorie diet can damage lipids, proteins, and DNA oxidation of the mucosa and lead to inflammation, apoptosis, damage of mucosal and its barrier. Moderate-intensity physical exercise is known to have health benefits, improve quality of life, reduce the risk of death, and prevent the occurrence of diseases related to oxidative stress. Aim of this study is to analyzed the effect of high-calorie diet and moderate-intensity physical exercise on gastric histopathological features of mice.</p> <p><strong>Methods:</strong> This research was a true experimental study with posttest only control group design. Female mice with Balb/C strain were randomly assigned into three groups, namely control group/K1 (n=12), high-calorie diet group/K2 (n=12), high-calorie diet and moderate-intensity physical exercise group/K3 (n=9). High-calorie diet was given in the form of ad libitum and sonde D40 with a dose of 3-5% of calories or 0.0325 mL/gBW. The moderate-intensity physical exercise was carried out by swimming thrice a week for 15 minutes using 6% gBW loading. After 4 weeks of treatment, mice were sacrificed and their stomach were sampled and prepared for microscopic analysis.</p> <p><strong>Results:</strong> Gastric histopathological analysis revealed no significant difference between the three study groups (p&gt;0,05).</p> <p><strong>Conclusions:</strong> There was no effect of a high-calorie diet and moderate-intensity physical exercise on the gastric histopathological features of mice (<em>Mus musculus</em>) in this study.</p> 2024-01-31T00:00:00+07:00 Copyright (c) 2024 Ramadhani Rizki Zamzam, Irfiansyah Irwadi, Alphania Rahniayu, Alphania Rahniayu Correlation of TED Laterality with Thyroid Status among Thyroid Eye Disease (TED) Patients in Tertiary Hospital in Indonesia 2023-11-29T16:19:59+07:00 Zahirah Siti Lutfiyah Delfitri Lutfi Hermawan Susanto Sutjipto <p><strong>Introduction</strong>: Thyroid eye disease (TED), an autoimmune thyroid disorder, prevalent in Asian countries and exhibits a variety of manifestations. Orbital involvement in TED is usually bilateral but may occur unilaterally in some cases. While it is commonly associated with hyperthyroidism, it also manifests in individuals with hypothyroidism or euthyroidism. The study aimed to analyze the relationship between TED laterality and thyroid status in patients with TED at Dr. Soetomo General Academic Hospital Surabaya's Eye Oncology Clinic.</p> <p><strong>Methods</strong>: An analytic observational study with a retrospective design was conducted. The study includes TED-diagnosed Dr. Soetomo General Hospital patients from January 2019 to December 2021. Medical records fulfilling sampling criteria were the data source, analyzed using SPSS.</p> <p><strong>Result</strong>: There were 88 samples that were dominated by females (57,95%) and aged 41 – 50 (32,96%). Proptosis was the most common clinical manifestation (94.32%), with compressive optic neuropathy was the least common (3,41%). Eyelid retraction occurred in only 22.7% of patients. TED was categorized into unilateral (44.32%) and bilateral (50.00%). The majority had hyperthyroidism (70.45%), followed by euthyroidism (25%), and hypothyroidism (4.55%). The analysis revealed a significant relationship between TED laterality and thyroid status. Compared to euthyroidism, hypothyroidism carried a 3.6 times higher risk of bilateral TED, while hyperthyroidism exhibited a 4.2 times higher risk of bilateral TED. Both hypothyroid and hyperthyroid status showed a similar susceptibility to bilateral TED development.</p> <p><strong>Conclusion</strong>: Patients with abnormal thyroid status, whether hyperthyroidism or hypothyroidism, are both more susceptible to developing bilateral TED compared to individuals with normal thyroid status.</p> 2024-01-31T00:00:00+07:00 Copyright (c) 2024 Zahirah Siti Lutfiyah, Delfitri Lutfi, Hermawan Susanto, Sutjipto The Clinical Outcome of COVID - 19 Infection On Chronic Diabetic Complications Patients 2023-11-29T11:19:54+07:00 Erlisa Pramodya Wardani Tri Pudy Asmarawati Isnin Anang Marhana Hermina Novida <p><strong>Int</strong><strong>r</strong><strong>oduction</strong><strong>: </strong>COVID-19 is a disease caused by SARS-CoV-2. That virus attacks the respiratory system and causes many deaths people in the world, so this virus was declared as pandemic in 2020. Until now, the Covid variant is still under WHO observation. One of the diseases that may worsen after infection is diabetes mellitus. Meanwhile, diabetes mellitus and complications are still a health problem in Indonesia and are one of the SDGS points. The study aims to evaluate the risks and output caused by COVID-19 infection and chronic complications of diabetes mellitus</p> <p><strong>Methods</strong><strong>: </strong>This Descriptive study and has a retrospective design. Research data was taken from the medical records of patients who were confirmed positive for COVID-19 infection and also had chronic complications of diabetes mellitus that were treated at Dr Soetomo General Academic Hospital, Surabaya, in 2021. There were 156 patients that met the criteria of this research.</p> <p><strong>Results</strong><strong>: </strong>There were 156 patients (97 male, 59 female), the average age is 58. The highest output of patients is death (84%), patients who can live are 16%. The highest causes of death in patients is patient with critical severity level and complications of microangiopathy (55,8%). Most patients alive are patients with moderate severity levels and microangiopathy complications (10,3%).</p> <p><strong>Conclusion</strong><strong>: </strong>Patients with positive confirmation of COVID-19 and having chronic complications of diabetes mellitus have the highest frequency of mortality, and sufferers are found in patients with microangiopathy complications and a critical level of COVID-19 severity.</p> <p><strong>&nbsp;</strong></p> <p><strong>Keywords</strong><strong>: </strong>COVID-19, Diabetes, Microangiopathy, Macroangiopathy</p> 2024-01-31T00:00:00+07:00 Copyright (c) 2024 erlisa pramodya wardani, Tri Pudy Asmarawati, Isnin Anang Marhana, Hermina Novida Association between the Duration of Steroid Therapy with Hyperglycemia in Patients with Systemic Lupus Erythematosus (SLE) 2024-01-30T15:32:44+07:00 Farahdiva Audrey Widyanrika Sony Wibisono Mudjanarko Maftuchah Rochmanti Deasy Ardiany Putu Bagus Dharma Permana <p><strong>Introductio</strong><strong>n: </strong><span style="font-weight: 400;">Systemic Lupus Erythematosus (SLE) is a systemic autoimmune disease which primary treatment consists of steroid drugs administration. Prolonged steroid administration is often associated with an increase in blood glucose, a condition known as hyperglycemia. Hence, this study aims to evaluate the association between the duration of steroid therapy with hyperglycemia in patients with SLE treated at a tertiary healthcare center in Surabaya, Indonesia.</span></p> <p><strong>Methods:&nbsp; </strong><span style="font-weight: 400;">A cross-sectional study was conducted under a purposive sampling frame from January to December of 2022 by utilizing secondary data from electronic medical health records in Dr. Soetomo General Hospital. The association between variables were analyzed using Fisher’s exact test, chi square test, independent T-test, one-way ANOVA, Mann-Whitney, and Spearman's rank correlation.</span></p> <p><strong>Results: </strong><span style="font-weight: 400;">Out of 150 included patients, 2.67% experience hyperglycemia following steroid therapy for SLE. There were no significant associations between clinical variables and hyperglycemia occurence in SLE patients (p&gt;0.05). Patients that received higher doses of steroid did not experience any significant difference in hyperglycemia (p=0.727 for &lt;6 months; p=0.865 for ≥6 months). Daily steroid dose was also not significantly associated with the severity of SLE manifestations based on the SLEDAI score (p=0.081). Overall, no significant association was identified between the duration of steroid therapy with hyperglycemia among SLE patients in the hospital (p=0.365).&nbsp;</span></p> <p><strong>Conclusion: </strong><span style="font-weight: 400;">There was no significant association between the duration of steroid therapy with the hyperglycemia occurence in patients with SLE in Dr. Soetomo General Hospital. Further research is warranted to investigate the impact of steroid treatment on the occurrence of hyperglycemia, employing a comparison in order to provide a more comprehensive understanding of the potential effects of this medication.</span></p> 2024-01-31T00:00:00+07:00 Copyright (c) 2024 Farahdiva Audrey Widyanrika, Sony Wibisono Mudjanarko, Maftuchah Rochmanti, Deasy Ardiany, Putu Bagus Dharma Permana Clinical and Demographic Profiling of Patients with Spondyloarthritis and Its Association with Disease Activty in Dr. Soetomo General Hospital, Surabaya 2024-01-30T21:49:53+07:00 Cahaya Prasta Yudha Lita Diah Rahmawati Yulia Nadar Indrasari Yuliasih <p><strong>Introduction:</strong> The assessment of disease activity is crucial for effectively managing chronic diseases like spondyloarthritis (SpA). Establishing the relationship between disease activity, demographic, and clinical factors is essential for better disease management. This study aims to delve into the demographic and clinical characteristics of patients at Dr. Soetomo General Hospital, contributing to a comprehensive understanding of SpA occurrences in the Surabaya region.</p> <p><strong>Methods:</strong> Data collection involved 38 SpA patients’ data classified using ASAS 2009 criteria at the Dr. Soetomo Hospital, excluding individuals with SLE, GOUT, RA, and Septic Arthritis. Disease activity was measured using ASDAS-CRP. Association analysis between disease activity, clinical parameters, and demographics was conducted via Mann-Withney U test and Spearman correlation.</p> <p><strong>Results:</strong> Results indicated a male-to-female ratio of 8:30, with patients having a median age of 48 (95% CI: 41-53) and most attaining a senior high school education (42.11%). The patients exhibited a mean BMI of 25.19 ± 3.77, a median disease duration of 8.5 (95% CI: 5-10) years, and a median CRP value of 0.2 (95% CI: 0.1-0.5) mg/dL. The majority displayed moderate disease activity, with a median ASDAS-CRP score of 2 (95% CI: 1.5-2.7). Interestingly, no significant correlation was found between disease activity using ASDAS-CRP and the demographic or clinical parameters studied.</p> <p><strong>Conclusion:</strong> No correlations between disease activities and both patients’ demography and clinical parameters in patients with SpA from Dr. Soetomo General Hospital, Surabaya, emphasizing the necessity for further research to comprehend the intricate relationship between disease activity and diverse influencing factors</p> 2024-01-31T00:00:00+07:00 Copyright (c) 2024 Cahaya Prasta Yudha, Lita Diah Rahmawati, Yulia Nadar Indrasari, Yuliasih Efficacy of Bay Leaf (Syzygium polyanthum) in Regulating Lipid Profile in Dyslipidemia Model Rats: A Systematic Review 2023-11-29T16:11:57+07:00 Trisilya Mita Anggrek Indri Safitri Mukono Maftuchah Rochmanti Citrawati Dyah Kencono Wungu <p><strong>Introduction: </strong>Cardiovascular disease is the leading cause of death in the world, more than any other disease. The leading cause of cardiovascular disease is dyslipidemia. Long-term use of simvastatin can cause other diseases. One of the medicinal plants known to have anti-cholesterol effects is a bay leaf (<em>Syzygium polyanthum</em>). This study aimed to determine how giving bay leaf extract regulates lipid profiles.</p> <p><strong>Methods:</strong> This study used a systematic review based on PRISMA guidelines. Sampling in this study was by collecting studies available in e-databases: PubMed and Google Scholar, with the inclusion criteria being experimental studies about the effect of giving bay leaf (<em>Syzygium polyanthum</em>) extract on regulating lipid profile in rats.</p> <p><strong>Results: </strong>This study consisted of 10 experimental studies on rats. Eight studies showed an improved lipid profile. Meanwhile, two studies did not show an improving lipid profile by giving a bay leaf extract.</p> <p><strong>Conclusion:</strong> Most studies revealed that a bay leaf extract positively improves lipid profiles by lowering total cholesterol, LDL, and triglycerides, increasing HDL levels, and having antioxidant and anti-inflammatory effects.</p> 2024-01-31T00:00:00+07:00 Copyright (c) 2024 Trisilya Mita Anggrek, Indri Safitri Mukono, Maftuchah Rochmanti, Citrawati Dyah Kencono Wungu Canagliflozin in Diabetes Mellitus Type 2: A Systematic Review 2023-11-29T16:17:00+07:00 Vikri Haikal Soebagijo Adi Soelistijo Puspa Wardhani Jongky Hendro Prajitno <p>One of the leading causes of death in patients with diabetes mellitus is Diabetic Kidney Disease (DKD). Canagliflozin is one of the therapeutic options that can be used to mitigate the progression of DKD. However, the limited existing studies have left the data regarding the effects of canagliflozin on the progression of DKD still unclear. Therefore, a comprehensive study on the efficacy and safety of using canagliflozin in patients with DKD is warranted. We performed systematically searches the PubMed, Cochrane Library, ResearchGate, and Springer for randomized, placebo-controlled trials of the treatment of type 2 diabetes mellitus (T2DM) with canagliflozin that were published on 9 January 2023. A total of 25 journals were identified, and after excluding irrelevant studies, eighteen studies were ultimately included in this systematic review. Canagliflozin reduces the rate of estimated glomerular filtration rate (eGFR) decline in patients with diabetes mellitus, reduction of urinary albumin-to-creatinine ratio (UACR) level is greater in canagliflozin group than in the control group, and the progression of albuminuria is slower in the canagliflozin group than in the control group. The use of Canagliflozin is considered to be one of the effective therapeutic options for kidney protection in patients with diabetes mellitus who are at risk of chronic kidney disease (CKD).</p> 2024-01-31T00:00:00+07:00 Copyright (c) 2024 Vikri Haikal, Soebagijo Adi Soelistijo, Puspa Wardhani, Jongky Hendro Prajitno Lupus Nephritis: A Literature Review 2024-01-30T15:27:05+07:00 Bestri Fortuna Awalia Puspa Wardhani <p>Systemic lupus erythematosus (SLE) manifests with diverse clinical presentations, notably including lupus nephritis (LN), characterized by elevated morbidity and mortality rates, the latter being twice that of non-nephritis cases. A comprehensive understanding of the epidemiology, classification, diagnosis, and management of LN is essential for medical practitioners. The preponderance of female individuals, particularly during puberty and childbearing age, emphasizes the necessity for specialized attention in clinical contexts. The diagnostic process involves an initial clinical examination to capture the disease's clinical profile, followed by supportive laboratory assessments aimed at identifying indications of kidney damage or general SLE symptoms, often featuring proteinuria. Integral to the diagnostic journey is the gold standard kidney biopsy examination for LN, supplemented by the antinuclear antibodies (ANA) test serving as a primary criterion in diagnostic evaluations. Therapeutic strategies are intricately tailored based on clinical and biopsy findings, categorized into five distinct classes (normal, mesangial, focal and segmental proliferative, diffuse proliferative, and membranous) according to World Health Organization (WHO) classification. The precise implementation of therapeutic interventions holds the potential to significantly enhance the overall prognosis of LN, underscoring the pivotal role of accurate diagnosis and targeted management in optimizing patient outcomes.</p> 2024-01-31T00:00:00+07:00 Copyright (c) 2024 Bestri Fortuna, Awalia, Puspa Wardhani Hepatocellular carcinoma with inferior vena cava thrombus in a child 2023-11-29T16:14:41+07:00 Fauziah Pratiwi Rendi Aji Prihaningtyas Bagus Setyoboedi Teddy Ontoseno <p>Pediatric HCC is an extremely rare type of liver cancer in children. Tumor thrombi in the IVC and RA are even rarer, with only 3-4% of patients experiencing them. The data on this condition in children is severely limited. We hereby present a case of a child with HCC and IVC thrombus that must be taken into serious consideration. A 13-year-old girl with hepatoblastoma has been admitted to the pediatric ward due to a year-long weight loss, along with a rapidly enlarging abdominal mass for six months, abdominal pain, recurrent vomiting, and lethargy. Her mother's history of icterus, abdominal pain, vomiting, and fever at the patient's age of four is also of concern. The child is suffering from high blood pressure, heart rate, and respiratory rate. Additionally, they have a fever, palpable liver with nodules, and ascites. Lab tests have confirmed anemia, abnormal liver function, and hepatitis B. Furthermore, imaging has exposed a thrombus in the inferior vena cava.</p> <p>&nbsp;</p> 2024-01-31T00:00:00+07:00 Copyright (c) 2024 Fauziah Pratiwi, Rendi Aji Prihaningtyas, Bagus Setyoboedi, Teddy Ontoseno