Current Internal Medicine Research and Practice Surabaya Journal <p><strong>Current Internal Medicine Research and Practice Surabaya Journal</strong> (CIMRJ) <a href="">e-ISSN: 2721-544X</a> is published by the Faculty of Medicine, Universitas Airlangga in collaboration with <a href="" target="_blank" rel="noopener">The Indonesian Society of Internal Medicine (PAPDI) branch of Surabaya</a>.</p> <p><strong>Current Internal Medicine Research and Practice Surabaya Journal</strong> classify the articles into Original Articles, Case Report, and Review Articles. It is published two times a year in January and August. Each issue publishes 7 articles. The scope of this journal includes allergy, endocrinology, gastroenterology, geriatrics, hematology, hepatology, nephrology, rheumatology, and tropical infection.</p> en-US <div id="custom-2"> <p>Copyright (c) Author</p> <p>CIMRJ provides immediate open access to its content and is licensed under Creative Commons attribution CC-BY (<a href="" target="_blank" rel="noopener"></a>). The license allows re-distribution and re-use of a licensed work on the conditions that the creator is appropriately credited and that any derivative work is made available under “the same, similar or a compatible license”. Other than the conditions mentioned above, the editorial board is not responsible for copyright violations. his license allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator. The license allows for commercial use. If you remix, adapt or build upon the material, you must license the modified material under identical terms.</p> <p> </p> <p> </p> </div> (Prof. Dr. Usman Hadi, dr., Sp.PD, K-PTI, FINASIM) (Athfiyatul Fatati) Mon, 31 Jan 2022 00:00:00 +0000 OJS 60 EXPANDED DENGUE SYNDROME <div class="WordSection1"><p><strong>ABSTRACT</strong></p><p>Dengue viral infection (DVI) is a debilitating arthropod-borne disease that has been rapidly spread in several regions of the world in recent years. The spectrum of disease varies from mild self-limiting illness to dengue fever (DF) to more severe and fulminating forms, i.e., dengue hemorrhagic fever (DHF), dengue shock syndrome (DSS),and expanded dengue syndrome (EDS). The pathogenesis of EDS is not clear amid lack of studies on animal models. In the absence of in vitro experiments, disease spectrum is difficult to be elucidated and mimicked for humans.Recent advances on research on atypical complications of EDS demonstrate the involvement of other major organs such as the kidney, lung, heart, and central nervous system. Histopathological findings demonstrate the presence of hemorrhage, edema, and inflammatory infiltrates in these organs.The spectrum of Dengue viral infection varies from mild self-limiting illness to dengue fever to more severe and fulminating forms, i.e., dengue hemorrhagic fever, dengue shock syndrome, and expanded dengue syndrome. Apart from the classical presentation, dengue infection can result in a myriad of unusual clinical manifestations, which are grouped under the title expanded dengue syndrome. These findings urge more focused and comprehensive investigations to explore such relationships so that high-risk patients could be identified immediately during their presentation to the hospitals.</p><p><strong>Keywords:</strong> Expanded dengue syndrome, Pathogenesis, Organ-specific manifestation</p></div> Agustinus Vincent, Bramantono -, Usman Hadi, Muhammad Vitanata Arifijanto Copyright (c) 2022 Current Internal Medicine Research and Practice Surabaya Journal Mon, 31 Jan 2022 00:00:00 +0000 CORRELATION OF METABOLIC SYNDROME WITH GENU OSTEOARTHRITIS IN TYPE 2 DIABETES MELLITUS PATIENTS <p><strong>Abstract</strong></p><p><strong>Introduction: </strong><em>Osteoarthitis</em>genu is a joint disorder of the genu section due to a gradual decrease in cartilage bone cohesiveness. A metabolic syndrome is a group of both lipid and non-lipid abnormalities in an individual. This study aims to determine the relationship between metabolic syndrome and the incidence of osteoarthritis genu in type 2 DM patients at RSI Jemursari Surabaya.</p><p><strong>Methods: </strong>This study uses an analytic observational method with a cross-sectional design. The population of type 2 DM patients and samples were obtained according to the inclusion and exclusion criteria. The sample size is 98 samples with a simple random sampling technique.</p><p><strong>Result:</strong> In this study, the frequency of the metabolic syndrome in this study (31.6%), age 55-65 years (38.7%), male gender (51.6%), and components of the metabolic syndrome include hypertension, type 2 diabetes, hypertriglyceridemia (83.9%). On the frequency of Genu Osteoarthritis (28.6%) with the age of 46-55 years (43%), female gender (61%). Osteoarthritis genu location distribution is mostly bilateral (60.7%). </p><p><strong>Conclusion: </strong>Based on the results of the Chi-Square Test statistical test using the SPSS statistical application, it shows a p significance value of 0.080 (&gt; 0,05).</p><p><strong> </strong></p><p><strong>Keywords: </strong>Metabolic syndrome, Osteoarthritis genu, DM type 2<strong></strong></p> Diaz Syafrie Abdillah, Ardyarini Dyah Savitri, Effendi . Copyright (c) 2022 Current Internal Medicine Research and Practice Surabaya Journal Mon, 31 Jan 2022 00:00:00 +0000 BIOFILM FORMATION AND ANTIMICROBIAL RESISTANCE OF ESCHERICHIA COLI IN VITRO TOWARDS CEFTRIAXONE AND CEFIXIME <p><strong>Introduction</strong>:<strong> </strong><em>Escherichia coli</em><strong> </strong>is a Gram-negative bacteria and a most cause of nosocomial infections. Bacteria has the ability to form biofilm that may cause antimicrobe resistance. This biofilm protects the microbes from environmental conditions which make it the most cause of nosocomial infections including urinary tract infection and the infections resulted from the use of medical instruments. The aim of this experiment is to observe the presence of cefotaxime and ceftriaxone antimicrobial resistance in <em>E. coli</em> as a cause of biofilm formation<em>.</em></p><p> <strong>Method</strong>: This study conducted three experiments<strong> </strong>of <em>E. coli</em> sensitivity test on cefotaxime and ceftriaxone, <em>E. coli</em> resistance test after a 48 hours incubation, and optical density measurement using iMark™ ELISA Microplate Reader.</p><p> <strong>Result</strong>: The results of sensitivity experiment with antibiotic cefotaxime and ceftriaxone disk showed sensitive result in wild-type <em>E. coli</em> and <em>E. coli</em> ATCC while after 48 hours incubation <em>E. coli</em> ATCC remains sensitive and in wild-type <em>E. coli</em> result are three intermediates, one sensitive and other than that it’s all change to resistance. The third experiment results were obtained from ELISA then classified into three categories. In <em>E. coli</em> ATCC 1 and 2, the results are mostly in high category (OD &gt;0.240). The OD in <em>E. coli</em> 1 is mostly high, while results from <em>E. coli</em> 2 consists of one bacterium in weak category (OD &lt;0.120), four in moderate category (OD 1.20 – 0.240), and three in high category.</p><p> <strong>Conclusion</strong>: It can be concluded that <em>E. coli</em> resistance test in cefotaxime and<strong> </strong>ceftriaxone after 48 hours’ incubation are mostly resistant in wild-type <em>E. coli</em> but sensitive in <em>E. coli</em> ATCC.</p> Jihan Kalishah, Dominicus Husada, M Vitanata Arfijanto, Agung Dwi Wahyu Widodo Copyright (c) 2022 Jihan Kalishah, Dominicus Husada, M Vitanata Arfijanto, Agung Dwi Wahyu Widodo Mon, 31 Jan 2022 00:00:00 +0000 CORRELATION BETWEEN HEALTHCARE SERVICE QUALITY AND HIV TESTING SERVICES PATIENT’S SATISFACTION IN KEDUNGDORO PRIMARY HEALTH CARE SURABAYA <p><strong>Introduction: </strong>Service quality of primary healthcare centre especially at HIV testing services must be improved. When the service quality is improved there will be a positive feedback such as patient’s satisfaction. Within the high patient satisfaction rate, People Living with HIV (PLWH) are expected to be more active, productive and also invited friends to check themselves, so the iceberg phenomenon will be revealed and prevention will be easier to control.</p><p><strong>Methods: </strong>This research used observational analytic design with purposive sampling method. The total research sample was 189 respondent, assess the questionnaire that consisted of five dimensions of service quality which were tangible, reliability, responsiveness, empathy and assurance, and also three indicators of patient satisfaction which were overall satisfaction, expectation and experience.</p><p><strong>Results: </strong>Among 189 respondents, mostly male with 129 responses or 68.3%, according to age group, mostly from 20-25 years old age group with 88 responses or 46.6% and according to time visit, mostly first visit patient with 162 responses or 85.8%. According to service quality, mostly categorized in a good group with 173 respondents or 91.5%. In patient satisfaction, mostly were categorized in a satisfy group with 157 respondents or 81.5%, There was a positive correlation between service quality and patient satisfaction with p value &lt;0.01 and correlation coefficient 0.632.</p><p><strong>Conclusion: </strong>There is a correlation between every dimension of service quality which are tangible, reliability, responsiveness, empathy and assurance with patient satisfaction of HIV testing services patient in Kedungdoro Primary Health Care Surabaya</p> Arinda Agung Katritama, Pudji Lestari, Muhammad Vitanata Arifijanto Copyright (c) 2022 Arinda Agung Katritama, Pudji Lestari, Muhammad Vitanata Arifijanto Mon, 31 Jan 2022 00:00:00 +0000 CHARACTERISTIC OF CHRONIC COMPLICATIONS IN TYPE 2 DIABETIC PATIENT BASED ON ASIAN PERSPECTIVE <p><strong>Introduction: </strong>Indonesia is in the 6<sup>th</sup> place with the most diabetes mellitus cases in the world. Long term exposure of hyperglycemia that can be seen in chronic type 2 diabetes mellitus patient can cause macrovascular and microvascular complications. This complication contributes to increase mortality rate in Indonesia.<strong></strong></p><p> <strong>Methods: </strong>This study uses cross sectional study by studying the medical record of type 2 diabetes mellitus patients, such as age, duration of diabetes mellitus, HbA1C levels, blood pressure, lipid profile, macrovascular and microvascular complication. The data obtained is reviewed descriptively.</p><p> <strong>Results: </strong>Most of type 2 diabetes mellitus patient is between 55-64 years (39.4%), mean 55.75 (SD=9.7). Most of the patients suffers type 2 diabetes mellitus for ≥5 years (61%). Meanwhile, the number of type 2 diabetes mellitus patients with uncontrolled HbA1C levels (≥7.0%) is 79%, mean 8.4 (SD= 1.8). Most of type 2 diabetes mellitus patients do not experience hypertension (77.8%) and experience dyslipidemia (94.3%), with the most prevalent lipid abnormality is high LDL (30.9%). Besides, most of type 2 diabetic patients have microvascular complications (57%), with the most common complication is diabetic neuropathy (45.6%), and the other microvascular complications are diabetic nephropathy (33.7%) and diabetic retinopathy (20.7%). While macrovascular complications is 43%, with the most common complication is diabetic foot (29.9%), and the other macrovascular complications are coronary heart disease (27.8%), peripheral arterial occlusive disease (22.9%), and stroke (19.4%).</p> Corina Ong Copyright (c) 2022 Current Internal Medicine Research and Practice Surabaya Journal Mon, 31 Jan 2022 00:00:00 +0000 DIAGNOSTIC AND MANAGEMENT PROBLEMS OF HYPERTHYROIDISM IN A PATIENT WITH TESTICULAR SEMINOMA <div>Patients with thyroid dysfunction are well represented in the general population. Hyperthyroidism can develop as a paraneoplastic syndrome in germ cell tumors. Testicular seminoma as a form of germ cell tumors, can express human chorionic gonadotropin (hCG). Beta-hCG strongly resembles TSH. A 26-year-old male with a history of cryptorchidism, came to Dr. Soetomo Hospital with the complaints of palpitation, diarrhea, weight loss, fatigue, nervousness, excessive sweating, and heat intolerance. He also complained of enlarged breast and a palpable mass in lower abdomen for 4 months. From the TSH and FT4 examinations, patient’s symptoms were in accordance with thyrotoxicosis. Anti-TPO and thyroid USG examination were within normal limits. Patient was treated with beta-blocker and thiamazole. Histopathology of abdominal mass showed a testicular seminoma. After surgery and chemoterapy, the clinical symptoms of hyperthyroidism gradually improved. Administration of beta-blocker and thiamazole was stopped in 4 months after surgery. Many of germ cell tumors in male are associated with cryptorchidism, half of them being testicular seminoma. Seminoma expresses hCG. At very high levels, hCG can stimulate the TSH receptors, causing hyperthyroidism or thyrotoxicosis. TSH and FT4 measurement were needed in patient with suspected hyperthyroidism. Anti-TPO test is performed to exclude autoimmune cause of thyroid disease. Symptomatic management of beta-hCG induced hyperthyroidism is not different from hyperthyroidism in general, namely administration of beta-blocker and anti-thyroid drugs. However, the definitive treatments are surgery and chemotherapy. Hyperthyroidism in germ cell tumors almost all responds well to surgery and chemotherapy.</div> <p class="MsoNormal" style="text-align: justify; line-height: normal; mso-pagination: none; mso-layout-grid-align: none; text-autospace: none; margin: .1pt 43.35pt .0001pt 41.0pt;"> </p> Dicky Febrianto, Hermina Novida Copyright (c) 2022 Dicky Febrianto, Hermina Novida Mon, 31 Jan 2022 00:00:00 +0000 SUICIDE ATTEMPT IN ELDERLY: AN OVERLOOKED COMPLICATION OF LATE-LIFE DEPRESSION <p>Suicide attempt in the elderly is underestimated and underreported due to cultural reference. Triggering factors may be the results of stressful life events or acquired late-life depression. An elderly woman, 69-year-old, was rushed to the emergency room due to household cleaning liquid ingestion. There was a history of previous suicide attempts and severe depressive episodes before. Since there was no sign of severe intoxication, then, the patient was treated symptomatically. Comprehensive geriatric and psychiatric assessments concluded that the patient was in a depressive state. The patient was discharged with symptomatic treatment and antidepressants but two weeks later she completed the course by drowning herself in a river. </p> Yhan Batista, Novira Widajanti, Agustina Konginan Copyright (c) 2022 Current Internal Medicine Research and Practice Surabaya Journal Mon, 31 Jan 2022 00:00:00 +0000