Indonesian Andrology and Biomedical Journal

A Improved Sexual Satisfaction Following Hyaluronic Acid Penile Filler Injection

2025-05-27T14:00:39+07:00

Background : Sexual satisfaction is a fundamental human need, and penis size is often regarded as an important factor for sexual satisfaction among men. Research indicates that penis size can also play a significant role in sexual satisfaction for women.

Case : This case report details the experience of a 37-year-old man who felt that his genital size was inadequate, leading to dissatisfaction during sexual intercourse.The patient underwent penile filler treatment using Hyaluronic Acid (HA), receiving a total of 12 cc. Following the injection, there was an increase in the circumference of his penis by 2 cm, resulting in improved patient satisfaction. Before the HA filler injection, the patient had an Index of Male Genital Image (IMGI) score of 58. A follow-up evaluation conducted one month later revealed an increase in the IMGI score to 70.

Discussion : Non-surgical penis enlargement procedures are commonly performed because they have a lower risk compared to surgical options. The most popular method involves the injection of hyaluronic acid (HA) fillers. This procedure is effective in enhancing sexual satisfaction, as it leads to a noticeable increase in the circumference of the penis, resulting in more fulfilling sexual experiences. HA fillers are biocompatible, long-lasting, and have a low incidence of complications or serious side effects.

Conclusion : This case demonstrates that Hyaluronic Acid is effective in enhancing the diameter of the penis and improving patient satisfaction.

Exploring the Interplay of Mental and Metabolic Factors in Erectile Dysfunction Management: A Case Report

2025-05-27T14:02:17+07:00

Background: Erectile dysfunction (ED) affects 20-50% of men globally and considerably diminishes the patients’ and their partners’ quality of life. This condition has multifactorial causes, including depression and metabolic syndrome, resulting in a complicated interaction of physical and psychological components.

Case: A man in his mid-twenties presented to the Andrology outpatient clinic at Dr. Soetomo General Hospital with a sudden onset of ED, reporting a decrease in his Erection Hardness Score (EHS) from 3-4 to 1 following penetration attempts. He had a history of childhood attention deficit hyperactivity disorder (ADHD) and recent unemployment, resulting in profound depression. Prior inconsistent treatments encompassed sertraline, fluvoxamine, and clobazam. Physical and laboratory examinations revealed metabolic syndrome. The patient was diagnosed with severe ED secondary to mixed etiology, class II obesity, major depressive episode, and metabolic syndrome. He received education on the diagnosis, possible underlying causes, and management options.

Discussion: The case presented illustrates the intricate interplay between ED and comorbidities such as depression and metabolic syndrome. Depression exacerbates ED through hormonal dysregulation and reduced parasympathetic activity, while metabolic syndrome contributes to ED through endothelial dysfunction and nitric oxide (NO) depletion. Effective ED management requires a multidisciplinary approach, combining lifestyle modifications, psychological support, and pharmacological treatment. Tailored strategies addressing both physical and psychological aspects are essential for improving outcomes.

Conclusion: Comprehensive and integrative care in managing ED, particularly when associated with complex comorbidities, is needed to enhance the patient’s erectile function and quality of life.

The Correlation Between Erectile Dysfunction and Coronary Heart Disease in Men at RSUP. Prof. Ngoerah

2025-06-12T09:11:30+07:00

Background : Coronary heart disease (CHD) has become one of the major economic burdens globally, as CHD has been the leading cause of mortality worldwide for the past 25 to 30 years. One of the factors that plays a role as a predictor of coronary heart disease is erectile dysfunction.

Objective : To investigate the correlation between erectile dysfunction and coronary heart disease in male patients at RSUP Prof. Ngoerah.

Methods : This research is an observational analytic study with a case-control design. Erectile dysfunction was measured using the IIEF-5 questionnaire, which consists of 5 items. Other risk factors were measured using a patient data questionnaire. The study sample consisted of 50 participants, divided into 25 cases and 25 controls. The case samples were male patients aged 25–60 with a history of coronary heart disease who were visiting or receiving treatment at the Cardiology Outpatient Clinic, Integrated Cardiac Services Building, RSUP Prof. Ngoerah, Denpasar. The control samples had the same criteria as the case samples but had no history of coronary heart disease.

Results : A significant relationship was found between erectile dysfunction and coronary heart disease (p=0.049), with an OR of 9.33 (95% CI 1.05–82.8).

Conclusion : There is a significant relationship between erectile dysfunction and coronary heart disease. Patients with erectile dysfunction have a 9.33 times higher likelihood of having coronary heart disease.

Differences in Sperm Motility Based on Sleep Quality in Infertilized Men at RSKIA Sadewa

2025-06-05T13:31:56+07:00

Background : Infertility is a significant reproductive health issue, with a global prevalence of 8–12% among couples of reproductive age. One contributing factor is decreased sperm quality, including sperm motility. Poor sleep quality is suspected to affect sperm motility through hormonal disruptions and oxidative stress; however, research in Indonesia remains limited.

Objective : This study aims to determine the differences in sperm motility based on sleep quality in infertile men at RSKIA Sadewa Yogyakarta.

Methods : This study employed an analytical observational design with a cross-sectional approach. The sample consisted of 60 infertile men aged 20–45 years who met the inclusion criteria. Sleep quality was measured using the Pittsburgh Sleep Quality Index (PSQI), while sperm motility data were obtained from medical records. Data were analyzed using the independent sample t-test and One-Way Anova.

Results : The results showed no significant difference in sperm motility between the good and poor sleep quality groups (p 0.374). The average sperm motility in the good sleep quality group was 48.43%, while in the poor sleep quality group, it was 43.90%. Confounding variables such as age, IMT, and smoking habits also did not show a significant effect on sperm motility.

Conclusion : Sperm motility in infertile men at RSKIA Sadewa who had good sleep quality was not significantly different compared to those with poor sleep quality.

Keywords : sleep quality, sperm motility, male infertility, PSQI, reproductive health

Ameliorative Effects of Eleutherine palmifolia Extract on Monosodium Glutamate-Induced Reproductive Toxicity: Modulation of Oxidative Stress Markers and Spermatogenesis in a Murine Model

2025-05-27T14:01:31+07:00

Background : Chronic monosodium glutamate (MSG) exposure is linked to testicular toxicity, impacting spermatogenesis and oxidative stress markers.

Objective : This study investigated the protective effects of Dayak onion (Eleutherine palmifolia) extract against MSG-induced testicular damage in mice.

Methods : Twenty-five male mice (11 weeks, ~20 g) were divided into five groups: negative control (C-, 0.5% CMC-Na), positive control (C+, MSG 4 mg/g BW), and treatment groups (T1, T2, T3) receiving MSG plus Dayak onion extract (30, 60, 120 mg/kg BW, respectively) for 52 days. On day 53, testicular histology and serum malondialdehyde (MDA) and superoxide dismutase (SOD) levels were analyzed. One-way ANOVA and Duncan’s post hoc test assessed differences (p<0.05).

Results : Group C+ showed significantly reduced spermatogenic cell counts, elevated MDA, and decreased SOD compared to C-. Group T1 exhibited no significant improvement in spermatogonia and spermatocytes but increased spermatids. Groups T2 and T3 significantly improved spermatogenic cell counts, with T3 showing the closest recovery to C-. MDA levels decreased, and SOD activity increased dose-dependently, with T3 nearing C- levels.

Conclusion : Dayak onion extract, particularly at 120 mg/kg BW, mitigates MSG-induced testicular toxicity, preserving spermatogenesis and balancing oxidative stress markers.

The Effect of Hyperbaric Oxygen Therapy on Male Infertility

2025-06-26T23:13:46+07:00

Background : Infertility is one of the major health concern on a global health problems. This is because around 15% of couples worldwide have difficulty conceiving. Along with advances in science and technology, researchers are trying to find and develop new treatment methods. One of the alternative therapies for infertility is hyperbaric oxygen therapy (HBOT).

Reviews : Infertility is a reproductive system disease in both men and women, characterized by the inability or failure to conceive after 12 months or more of regular unprotected sexual intercourse. In the management of infertility, HBOT can help improve sperm quality and spermatogenesis, the process of sperm formation, thereby contributing to increased fertilization. In addition, HBOT can increase oxygenation of testicular tissue, thereby increasing normal sperm count and good motility, which are essential for fertilization.

Summary : HBOT can improve sperm viability and motility. By increasing vascularization, tissue oxygenation, and improving post-procedure conditions, HBOT may potentially improve fertility outcomes.

Keywords : Hyperbaric Oxygen Therapy (HBOT), Male Infertility, Sperm.