Effectivity of 5% Dextrose-Diluted and Ringer Lactate-Diluted Propofol to Reduce Intravenous Injection Pain in Pediatric Patient

Dian Raseka Parna, Arie Utariani, Elizeus Hanindito

= http://dx.doi.org/10.20473/ijar.V2I12020.33-37
Abstract views = 164 times | downloads = 241 times

Abstract


Introduction: Propofol has been known as one out of many inductive drugs which, can cause pain during intravenous injection. There has been a high prevalence of injection pain in pediatric patients. The mechanism of injection pain has not been known. Some therapeutic methods have been tested to reduce the pain, with several success rates. Objective: To compare the effectivity of 5% dextrose-diluted propofol and ringer lactate-diluted propofol, with dilution comparison of 1:1, in their role to reduce intravenous injection pain in pediatric patients, from age 2-15 years old during elective surgery in the Integrated Surgical Building Center of Dr. Soetomo General Hospital Surabaya. Method and Material: Forty-five patients PS ASA I-II, which fulfill inclusion criteria, were induced with general anesthesia. Patients had been selected randomly into three groups. Group I (control group) were injected with propofol without dilution. Group II was injected with propofol with a dilution of 5% dextrose, into 5 mg/ml liquid. Group III was injected with propofol with a dilution of ringer lactate, into 5 mg/ml liquid. Result and Discussion: The level of pain was evaluated afterward, with responding to the four-point scale and spontaneous expression. Patients’ blood pressure, mean arterial pressure, heart rate, and oxygen saturation were also examined after injection. Compared to the control group, those in groups with 5% dextrose-diluted and ringer lactate-diluted propofol are not effective in reducing intravenous injection pain, with analytical statistics p=0.503 (p > 0.05). Also, the dilution of propofol has no significant difference to the hemodynamic measurement of patients. Systolic and diastolic blood pressure, and mean arterial pressure were declined after the induction, but statistically insignificant. The heart rate of patients was inclined but also not significant. Conclusion: 5% dextrose-diluted and ringer lactate-diluted propofol with a comparison of 1:1 were not significantly effective in reducing intravenous injection pain in pediatric patients.

Keywords


5% Dextrose; Ringer Lactate; Propofol Dilution; Injection Pain; Pediatric Pain

Full Text:

PDF

References


Soenarto, Ratna F, Chandra S. Buku Ajar Anestesiologi. Departemen Anestesiologi dan Intensive Care Fakultas Kedokteran Universitas Indonesia / RS Cipto Mangunkusumo. Jakarta. 2012;

Rekapitulasi Pasien Operasi Elektif Gedung Bedah Pusat Terpadu.

Surabaya: Departemen Anestesiologi dan Reanimasi Fakultas Kedokteran

Universitas Airlangga / RSUD Dr Soetomo Surabaya. 2013-2014;

Stoelting RK and Hiller SC. Pharmacology & Physiology in Anesthetic Practice 4th Edition. Philadelphia. 2006;

Liljeroth, Elisabeth. Pain Induced by Propofol – Clinical Studies on Drug

Composition and Administration. Department of Anesthesiology and

Intensive Care, Malmo University Hospital, Lund University. Malmo. 2007;

Klement W, Arndt JO. Pain on Injection of Propofol: Effects of Concentration and Diluent. Br J Anaesth. 1991; 67: 281-284.

Macario A, Weinger M, Truong P and Lee M. Which Clinical Anesthesia

Outcomes are Both Common and Important to Avoid? The Perspective of a Panel of Expert Anesthesiologist. Anesth Analg. 1999; 88:1085-1091.

Jalota, Leena et al. Prevention of Pain on Injection of Propofol: Systematic Review and Meta-analysis. BMJ 2011; 342: d1110.

Soltesz S, Silomon M, Graf G, Mencke T, Boulaadass S, Molter GP. Effect of 0,5% Dilution of Propofol on Pain on Injection During Induction of Anesthesia in Children. Anesthesiology. 2007; 106: 80-84.

Yamakage M, Iwasaki S, Satoh JI and Namiki A. Changes in Concentrations of Free Propofol by Modification of the Solution. Anesth Analg. 2005; 101:385-388.

Butterworth JF, Mackey DC, Wasnick JD. Morgan & Mikhail’s Clinical Anesthesiology 5th Edition. East Norwalk: Appleton & Lange. 2013;

William EL, Hildebrand KL, McCormick SA, Bedel MJ. The effect of intravenous lactated Ringer’s solution versus 0,9% sodium chloride solution on serum osmolality in human volunteers. Anesth. Analg. 1999; 88 (5): 999-100.


Refbacks

  • There are currently no refbacks.


Copyright (c) 2020 Indonesian Journal of Anesthesiology and Reanimation

View My Stats

INDEXED BY:

   

 

P-ISSN: 2722-4554

E-ISSN: 2686-021X

Creative Commons Licence
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.