Initial Sofa Score and Mortality of Sepsis Patients in the Intensive Care Unit of Haji Adam Malik Hospital Medan: Does It Correlate?
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Introduction: Sepsis is a life-threatening organ dysfunction or failure that is the primary cause of death in infectious disease. the Sepsis-3 Task Force recommends The Sequential (Sepsis-Related) Organ Failure Assessment (SOFA) Score as a means of Sepsis identification. Objective: To determine the correlation between sepsis patients’ deaths in the intensive care unit (ICU) of Haji Adam Malik Hospital Medan and their initial SOFA score. Methods: This study uses a cross-sectional study design and an observational analytical investigation. The sample for this study was sepsis patients who were treated in the ICU of Haji Adam Malik Hospital Medan in 2021-2022, and they were selected using the purposive sampling method. After calculating the Slovin formula, 61 samples are required. The researchers obtained the data from patient medical records. The analyses used are univariate and bivariate, with the Independent-T test and Fisher’s exact. Results: From 71 patients, there were 36 patients (50.7%) in the age group of 46-65 years old; 39 patients (54.9%) were male; 50 patients (70.4%) had comorbidities; and 50 patients (70.4%) had non-surgical disease. The average initial SOFA score was 9.89 ± 3.95, with mortality for sepsis patients in the ICU of 74.6%. The findings of the statistical analysis indicated a substantial difference (p<0.001) in the SOFA scores of those who survived and those who did not, as well as a significant correlation (p<0.001) between the initial SOFA score and mortality. Conclusion: There is a correlation between initial SOFA score and the mortality of sepsis patients in the ICU of Haji Adam Malik Hospital.
Fleischmann-Struzek C, Mellhammar L, Rose N, Cassini A, Rudd KE, Schlattmann P, et al. Incidence and mortality of hospital- and ICU-treated sepsis: results from an updated and expanded systematic review and meta-analysis. Vol. 46, Intensive Care Medicine. Springer; 2020. p. 1552–62. [WebPage] [PubMed]
Rudd KE, Johnson SC, Agesa KM, Shackelford KA, Tsoi D, Kievlan DR, et al. Global, regional, and national sepsis incidence and mortality, 1990-2017: analysis for the Global Burden of Disease Study. Lancet. 2020 Jan 18;395(10219):200–11. [WebPage] [PubMed]
Singer M, Deutschman CS, Seymour C, Shankar-Hari M, Annane D, Bauer M, et al. The third international consensus definitions for sepsis and septic shock (sepsis-3). Vol. 315, JAMA - Journal of the American Medical Association. American Medical Association; 2016. p. 801–10. [WebPage] [PubMed]
Fauziyah HTA, Semedi BP, Lestari P, Maulydia M. Analisis Sistem Skoring APACHE II dan SOFA Terhadap Outcome di Intensive Care Unit RSUD Dr. Soetomo Surabaya. JAI (Jurnal Anestesiologi Indonesia). 2021 Jul;13(2):99-113. https://doi.org/10.14710/jai.v13i2.33984. [WebPage]
Iskandar A, Siska F. Analisis Hubungan Sequential Organ Failure Assessment (SOFA) Score Dengan Mortalitas Pasien Sepsis. Jurnal Kesehatan Andalas. 2020;168–73. [WebPage]
Thakur P, Ahad S, Ommid M, Shah RM, Haq I. Evaluation of sequential organ failure assessment (SOFA) score as an indicator of 30 days mortality in patients with sepsis admitted in surgical ICU [Internet]. 2022. Available from: https://sciencescholar.us/journal/index.php/ijhs/article/view/13425. [WebPage]
Jain A, Palta S, Saroa R, Palta A, Sama S, Gombar S. Sequential organ failure assessment scoring and prediction of patient’s outcome in Intensive Care Unit of a tertiary care hospital. J Anaesthesiol Clin Pharmacol. 2016 Jul 1;32(3):364–8. [WebPage] [PubMed]
Dahlan MS. Pintu Gerbang Memahami Statistik, Metodologi, dan Epidemiologi. Jakarta; 2018.
Ko RE, Kang D, Cho J, Na SJ, Chung CR, Lim SY, et al. Influence of gender on age-associated in-hospital mortality in patients with sepsis and septic shock: a prospective nationwide multicenter cohort study. Crit Care. 2023 Jun 11;27(1):229. [WebPage] [PubMed]
Kabi A, Mohanty A, Kumar S, Singh V, Jha M, Gupta P. Clinical spectrum and risk factors for hospital-acquired septicemia in a tertiary care centre of North-East India. J Family Med Prim Care. 2020;9(8):3949. [WebPage] [PubMed]
Lakbar I, Einav S, Lalevée N, Martin-Loeches I, Pastene B, Leone M. Interactions between Gender and Sepsis—Implications for the Future. Microorganisms. 2023 Mar 14;11(3):746. [WebPage] [PubMed]
Kartika Sari E, Sri Hayati Y, Lestari Rokhmawati N. Hubungan Skor SOFA dengan Mortalitas pada Pasien Sakit Kritis. Vol. 8, Majalah Kesehatan. 2021. [WebPage]
Sinapidis D, Kosmas V, Vittoros V, Koutelidakis IM, Pantazi A, Stefos A, et al. Progression into sepsis: an individualized process varying by the interaction of comorbidities with the underlying infection. BMC Infect Dis. 2018 Dec 29;18(1):242. [WebPage] [PubMed]
Mewes C, Runzheimer J, Böhnke C, Büttner B, Nemeth M, Hinz J, et al. Differences in Mortality and Sepsis-Associated Organ Dysfunction between Surgical and Non-Surgical Sepsis Patients. Biomedicines [Internet]. 2023 Aug 9;11(8):2233. Available from: https://www.mdpi.com/2227-9059/11/8/2233. [WebPage] [PubMed]
Huang M, Cai S, Su J. The pathogenesis of sepsis and potential therapeutic targets. Vol. 20, International Journal of Molecular Sciences. MDPI AG; 2019. [WebPage] [PubMed]
Purwanto DS, Astrawinata DAW. Mekanisme Kompleks Sepsis dan Syok Septik. Jurnal Biomedik (JBM). 2018. [WebPage]
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