The Experiences of Cancer-Related Fatigue among Adult Cancer Patients: A Systematic Review
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Introduction:Cancer-related fatigue (CRF) is one of the symptoms commonly experienced and it is a subjective feeling felt by cancer patients. The aim of this systematic review was to summarize how fatigue has been described from the perspective of adult cancer patients, the impact of fatigue on their quality of life, what the patient reported as contributing factors and potential coping strategies to reduce fatigue.
Methods: A systematic review is in line with PRISMA guidelines. Five databases were systematically searched (Scopus, PubMed, Springerlink, ProQuest and Science Direct) from January 2009 to February 2019 for qualitative studies describing the experience of adult cancer patients using a predefined search strategy and any relevant keywords.
Results: In total, 13 out of 4692 studies were included. The ages of the included patient cancer ranged from 26 to 84 years. The majority of studies used in-depth interviews and semi-structured interviews to elicit the participant's experiences of fatigue. Four themes were identified: the perception of cancer-related fatigue, the etiology of cancer fatigue, impact and coping strategies.
Conclusion: Fatigue is impactful on quality of life from the perspective of cancer patients. Future research should focus on the prospective exploration of the impact of fatigue on woman's and men's health and identifying approaches to reduce fatigue.
Abrahams, H. J. ., Gielissen, M. F. ., Schmits, I. ., Verhagen, C. A. H. H. V. ., Rovers, M. ., & Knoop, H. (2016). Risk Factors, Prevalence, and Course of Severe Fatigue After Breast Cancer Treatment: A Meta-Analysis.
Al-Azri, M., Al-Awisi, H., Al-Rasbi, S., El-Shafie, K., Al-Hinai, M., Al-Habsi, H., & Al-Moundhri, M. (2014). Psychosocial impact of breast cancer diagnosis among Omani women. Oman Medical Journal, 29(6), 437–444. https://doi.org/10.5001/omj.2014.115
Balachandran, D. D., Faiz, S., Bashoura, L., & Manzullo, E. (2013). Cancer-related fatigue and sleep disorders. Sleep Medicine Clinics. https://doi.org/10.1016/j.jsmc.2013.02.005
Berger, A. M., Gerber, L. H., & Mayer, D. K. (2012). Cancer-related fatigue: Implications for breast cancer survivors. Cancer, 118(SUPPL.8), 2261–2269. https://doi.org/10.1002/cncr.27475
Blaney, J., Lowe-Strong, A., Rankin, J., Campbell, A., Allen, J., & Gracey, J. (2010). The cancer rehabilitation journey: barriers to and facilitators of exercise among patients with cancer-related fatigue. Physical Therapy, 90(8), 1135–1147. https://doi.org/10.2522/ptj.20090278
Borneman, T., Uman, G. C., Munevar, C. M., Sun, V., Piper, B. F., Koczywas, M., & Ferrell, B. R. (2012). A Qualitative Analysis of Cancer-Related Fatigue in Ambulatory Oncology. Clinical Journal of Oncology Nursing, 16(1), E26–E32. https://doi.org/10.1188/12.cjon.e26-e32
Bower, J. E. (2014). Cancer-related fatigue--mechanisms, risk factors, and treatments. Nature Reviews. Clinical Oncology, 11(10), 597–609. https://doi.org/http://dx.doi.org/10.1038/nrclinonc.2014.127
Charalambous, A., & Kouta, C. (2016). Cancer Related Fatigue and Quality of Life in Patients with Advanced Prostate Cancer Undergoing Chemotherapy. BioMed Research International, 2016. https://doi.org/http://dx.doi.org/10.1155/2016/3989286
Cordero, E. D., Dimsdale, J. E., & Navarro, A. M. (2015). Feeling "Pooped” and "Run down?”: Fatigue experiences in latino cancer patients. Journal of Applied Biobehavioral Research, 20(1), 1–24. https://doi.org/10.1111/jabr.12030
Giacalone, A., Quitadamo, D., Zanet, E., Berretta, M., Spina, M., & Tirelli, U. (2013). Cancer-related fatigue in the elderly. Supportive Care in Cancer, 21(10), 2899–2911. https://doi.org/10.1007/s00520-013-1897-1
Hodge, F. S., Itty, T. L., Cadogan, M. P., Martinez, F., & Pham, A. (2015). The cultural constructs of cancer-related fatigue among American Indian cancer survivors. Supportive Care in Cancer. https://doi.org/10.1007/s00520-015-2902-7
Hodge, F. S., Itty, T. L., Cadogan, M. P., Martinez, F., & Pham, A. (2016). The cultural constructs of cancer-related fatigue among American Indian cancer survivors. Supportive Care in Cancer, 24(3), 1235–1240. https://doi.org/http://dx.doi.org/10.1007/s00520-015-2902-7
Hopewood, P., & Milroy, J. M. (2018). Quality Cancer Care: Survivorship Before, During and After Treatment. Clinical Journal of Oncology Nursing (Vol. 17). Cham, Switzerland: Springer. https://doi.org/10.1188/13.CJON.111-112
Horneber, M., Fischer, I., Dimeo, F., Rüffer, J. U., & Weis, J. (2012). Cancer-Related Fatigue, 109(9). https://doi.org/10.3238/arztebl.2012.0161
Howell, D., Oliver, T. K., Hack, T. F., Broadfield, L., Biggs, K., Chung, J., ... Olson, K. (2013). A pan-Canadian practice guideline and algorithm : screening , assessment , and supportive care of adults with cancer-related fatigue, 20, 233–246.
Hudson, M. M., Ness, K. K., Gurney, J. G., Mulrooney, D. A., Chemaitilly, W., Krull, K. R., ... Robison, L. L. (2013). Clinical ascertainment of health outcomes among adults treated for childhood cancer. JAMA - Journal of the American Medical Association. https://doi.org/10.1001/jama.2013.6296
Jakobsson, S., Taft, C., Östlund, U., & Ahlberg, K. (2013). Performance of the Swedish version of the Revised Piper Fatigue Scale. European Journal of Oncology Nursing, 17(6), 808–813. https://doi.org/https://doi.org/10.1016/j.ejon.2013.07.004
Karthikeyan, G., Jumnani, D., Prabhu, R., Manoor, U. K., & Supe, S. S. (2012). Prevalence of fatigue among cancer patients receiving various anticancer therapies and. Indian Journal of Palliative Care, 18(3), 165–175. https://doi.org/10.4103/0973-1075.105686
Levkovich, I., Cohen, M., & Karkabi, K. (2017). The Experience of Fatigue in Breast Cancer Patients 1-12 Month Post-Chemotherapy: A Qualitative Study. Behavioral Medicine (Washington, D.C.), 1–12. https://doi.org/10.1080/08964289.2017.1399100
Liberati, A., Altman, D. G., Tetzlaff, J., Mulrow, C., Gí¸tzsche, P. C., Ioannidis, J. P. A., ... Moher, D. (2009). The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions : Explanation and Elaboration, 6(7). https://doi.org/10.1371/journal.pmed.1000100
Moher, D., Tetzlaff, J., Altman, D. G., Liberati, A., & Group, P. (2009). Preferred reporting items for systematic reviews and meta-analyses : the PRISMA statement, 339(august). https://doi.org/10.1136/bmj.b2535
Molassiotis, A., Lowe, M., Blackhall, F., & Lorigan, P. (2011). A qualitative exploration of a respiratory distress symptom cluster in lung cancer: Cough, breathlessness and fatigue. Lung Cancer, 71(1), 94–102. https://doi.org/10.1016/j.lungcan.2010.04.002
Morrow, G. R., Carroll, J. K., Figueroa-Moseley, C. D., Mustian, K. M., Jean-Pierre, P., & Williams, G. C. (2007). Integrative Nonpharmacologic Behavioral Interventions for the Management of Cancer-Related Fatigue. The Oncologist, 12(suppl_1), 52–67. https://doi.org/10.1634/theoncologist.12-s1-52
Mortimer, J. E., Barsevick, A. M., Bennett, C. L., Berger, A. M., Cleeland, C., DeVader, S. R., ... Rugo, H. S. (2010). Studying cancer-related fatigue: Report of the NCCN scientific research committee. JNCCN Journal of the National Comprehensive Cancer Network, 8(12), 1331–1339. https://doi.org/10.6004/jnccn.2010.0101
Nowe, E., Stöbel-Richter, Y., Sender, A., Leuteritz, K., Friedrich, M., & Geue, K. (2017). Cancer-related fatigue in adolescents and young adults: A systematic review of the literature. Critical Reviews in Oncology/Hematology, 118(September 2016), 63–69. https://doi.org/10.1016/j.critrevonc.2017.08.004
Pertl, M. M., Quigley, J., & Hevey, D. (2014). "I'm not complaining because I'm alive”: Barriers to the emergence of a discourse of cancer-related fatigue. Psychology and Health, 29(2), 141–161. https://doi.org/10.1080/08870446.2013.839792
Prue, G., Rankin, J., Allen, J., Gracey, J., & Cramp, F. (2006). Cancer-related fatigue: A critical appraisal. European Journal of Cancer, 42(7), 846–863. https://doi.org/10.1016/j.ejca.2005.11.026
Ripamonti, C. I., Antonuzzo, A., Bossi, P., Cavalieri, S., Roila, F., & Fatigoni, S. (2018). Fatigue , a major still underestimated issue, 219–225. https://doi.org/10.1097/CCO.0000000000000451
Rosman, S. (2009). "Recovered from cancer but still ill”: Strategies used to legitimise extreme persistent fatigue in disease-free cancer patients. European Journal of Cancer Care, 18(1), 28–36. https://doi.org/10.1111/j.1365-2354.2007.00863.x
Saligan, L. N., Olson, K., Filler, K., Larkin, D., Cramp, F., Sriram, Y., ... Palesh, O. (2015). The biology of cancer-related fatigue : a review of the literature. https://doi.org/10.1007/s00520-015-2763-0
Scott, J. A., Lasch, K. E., Barsevick, A. M., & Piault-Louis, E. (2011). Patients' Experiences With Cancer-Related Fatigue: A Review and Synthesis of Qualitative Research. Oncology Nursing Forum, 38(3), E191–E203. https://doi.org/10.1188/11.ONF.E191-E203
Servaes, P., Verhagen, C., & Bleijenberg, G. (2002). Fatigue in cancer patients during and after treatment : prevalence , correlates and interventions, 38, 27–43.
Shuster, J. J. (2011). Review: Cochrane handbook for systematic reviews for interventions, Version 5.1.0, published 3/2011. Julian P.T. Higgins and Sally Green, Editors. Research Synthesis Methods, 2(2), 126–130. https://doi.org/10.1002/jrsm.38
Siegel, K., Lekas, H.-M., & Maheshwari, D. (2012). Causal attributions for fatigue by older adults with advanced cancer. Journal of Pain and Symptom Management, 44(1), 52–63. https://doi.org/10.1016/j.jpainsymman.2011.07.013
Spichiger, E., Rieder, E., Müller-Fröhlich, C., & Kesselring, A. (2012). Fatigue in patients undergoing chemotherapy, their self-care and the role of health professionals: A qualitative study. European Journal of Oncology Nursing, 16(2), 165–171. https://doi.org/10.1016/j.ejon.2011.05.002
Tong, A., Sainsbury, P., & Craig, J. (2007). Consolidated criteria for reporting qualitative research (COREQ): A 32-item checklist for interviews and focus groups. International Journal for Quality in Health Care. https://doi.org/10.1093/intqhc/mzm042
Tran, G., & Zafar, S. Y. (2018). Financial toxicity and implications for cancer care in the era of molecular and immune therapies. Annals of Translational Medicine, 6(9), 166–166. https://doi.org/10.21037/atm.2018.03.28
Tsai, S. L., Lin, H. R., Chao, T. Y., & Lin, P. F. (2010). The fatigue experiences of older Taiwanese women with breast cancer. Journal of Clinical Nursing, 19(5–6), 867–875. https://doi.org/10.1111/j.1365-2702.2009.03064.x
Watson, A., & van Kessel, K. (2016). Cancer Survivors' Experiences and Explanations of Postcancer Fatigue. Cancer Nursing, 41(2), 117–123. https://doi.org/10.1097/ncc.0000000000000460
Weber, D., & O'Brien, K. (2017). Cancer and Cancer-Related Fatigue and the Interrelationships With Depression, Stress, and Inflammation. Journal of Evidence-Based Complementary and Alternative Medicine, 22(3), 502–512. https://doi.org/10.1177/2156587216676122
Werdani, Y. D. W. (2018). Effect of Cancer Related Fatigue to The Level of Independence of Cancer Patients and Caregiver Stress Level. Folia Medica Indonesian, 54, 108–112.
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