GFR and Blood Lead Levels in Gas Station Workers Based on δ-Alad Gene Polymorphisms
Vol. 10 No. 1 (2015): April 2015
Original Article
April 1, 2015
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Methods: A cross-sectional design was used to perform this research. Thirty-eight gas stations workers in Banyumas were recruited in this study. δ-ALAD gene polymorphisms were characterized using PCR-RFLP method, while lead serum levels were quantifi ed by Atomic Absorption Spectrophotometer (AAS). In addition, Creatinin serum was done with a spectrophotometer and GFR value was formulated by means of the Schwartz method.
Result: The study showed that the proportion of ALAD genotype for ALAD 1-1, 1-2 and 2-2 were 94.7%, 5.3%, and 0% respectively. The mean of serum levels in homozygous 1-1 was 15.94 ppb and heterozygote 1-2 was 1.15 ppb. GFR of participants ranged from 71.11 mL/min to 185.20 mL/min with a mean of 117.34mL/min. There was no correlation between serum Pb and GFR (p = 0.19). Study also could not determine the correlation between GFR and ALAD gene Polymorphism.
Conclusion: Study then concluded that there was no correlation between blood lead levels in the GFR on each δ-ALAD genotypes.
Rujito, L., Hanief, M. N., Gozali, P., & Mulyanto, J. (2015). GFR and Blood Lead Levels in Gas Station Workers Based on δ-Alad Gene Polymorphisms. Jurnal Ners, 10(1), 74–79. https://doi.org/10.20473/jn.v10i1.1878
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Jacobs, D., R. Clickner, J.Y. Zhou, S.E. Viet, D. Marker and J. Rogers, 2002. The Prevalence of Lead-Based Paint Hazards in U.S. Housing. Environ. Hlth Perspect., 10: 599–606.
Ye, X. and O. Wong, 2006. Lead exposure, lead poisoning, and lead regulatory standards in China, 1990–2005. Regul. Toxicol. Pharmacol,, 2: 157–162.
Santi, D.N., 2007. Pencemaran Udara oleh Timbal (Pb) serta Penanggulangannya. Media Fakultas Kedokteran Universitas
Sumatera Utara, 1: 10–16.
Hirose, A., A. Takagi, T. Nishimura and J.E. Kanno, 2004. Review of Reproduction and Developmental Toxicity Induced by
Organization in Aquatic Organism and Experimental Animal. Organohalogen Compound, 66: 3042–3047.
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