GFR and Blood Lead Levels in Gas Station Workers Based on δ-Alad Gene Polymorphisms
Downloads
Methods: A cross-sectional design was used to perform this research. Thirty-eight gas stations workers in Banyumas were recruited in this study. δ-ALAD gene polymorphisms were characterized using PCR-RFLP method, while lead serum levels were quantifi ed by Atomic Absorption Spectrophotometer (AAS). In addition, Creatinin serum was done with a spectrophotometer and GFR value was formulated by means of the Schwartz method.
Result: The study showed that the proportion of ALAD genotype for ALAD 1-1, 1-2 and 2-2 were 94.7%, 5.3%, and 0% respectively. The mean of serum levels in homozygous 1-1 was 15.94 ppb and heterozygote 1-2 was 1.15 ppb. GFR of participants ranged from 71.11 mL/min to 185.20 mL/min with a mean of 117.34mL/min. There was no correlation between serum Pb and GFR (p = 0.19). Study also could not determine the correlation between GFR and ALAD gene Polymorphism.
Conclusion: Study then concluded that there was no correlation between blood lead levels in the GFR on each δ-ALAD genotypes.
Jacobs, D., R. Clickner, J.Y. Zhou, S.E. Viet, D. Marker and J. Rogers, 2002. The Prevalence of Lead-Based Paint Hazards in U.S. Housing. Environ. Hlth Perspect., 10: 599–606.
Ye, X. and O. Wong, 2006. Lead exposure, lead poisoning, and lead regulatory standards in China, 1990–2005. Regul. Toxicol. Pharmacol,, 2: 157–162.
Santi, D.N., 2007. Pencemaran Udara oleh Timbal (Pb) serta Penanggulangannya. Media Fakultas Kedokteran Universitas
Sumatera Utara, 1: 10–16.
Hirose, A., A. Takagi, T. Nishimura and J.E. Kanno, 2004. Review of Reproduction and Developmental Toxicity Induced by
Organization in Aquatic Organism and Experimental Animal. Organohalogen Compound, 66: 3042–3047.
Authors who publish with Jurnal Ners agree to the following terms:
- Authors transfer the Copyright and grant Jurnal Ners the right of first publication with the work simultaneously licensed under a Creative Commons Attribution 4.0 International License that allows others to remix, adapt and build upon the work with an acknowledgment of the work's authorship and of the initial publication in Jurnal Ners.
- Authors are permitted to copy and redistribute the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in Jurnal Ners.
Jurnal Ners requires a formal written declaration and transfer of copyright from the author(s) for each article published. We, therefore, ask you to complete and return this form, retaining a copy for your own records. Your cooperation is essential and appreciated. Any delay will result in a delay in publication. The form can be downloaded HERE.