The Effectiveness of Mangosteen Peels Extract Against The Total of T Lymphocytes in HIV Patients

Maria Dyah Kurniasari, Edi Dharmana, Hussein Gasem

Abstract views = 866 times | downloads = 750 times


Introduction: The Province of West Java is one of the highest HIV sufferers in Indonesia that has increased accumulatively in 2013 to 2014. This condition was proven that in 2014 West Java ranked 4th among the provinces with the highest HIV sufferers in Indonesia. HIV has main target to infect a cell that contains of receptor, CD4. CD4 examination routinely is very important to decide HIV replication process. Meanwhile, CD4 test in the laboratory is quite expensive and not always available in every health facilities. Mangosteen peels extract contains of xanthones as an antioxidant, which is needed for body as a prooxidant that can inhibit the replication of HIV and the activity was seen from the total number of lymphocyte.

Method:  The human experimental research has been done by Randomized Control Group Pretest-Post Test Design. There were 20 patients sample for each group. In group 1, HIV patients with ARV therapy were given mangosteen peels extract and in group 2, they were given placebo capsule. Wilcoxon Smith test and Mann Whitney U test were used to determine the difference between group 1 and group 2.

Result: There is no significant difference between lymphocytes (p: 0.102) to HIV patients with ARV in each group examination. Discussion: The ineffectiveness is caused by the phagocytocity and cytoxity of TNF through the increasing of free radicals in HIV patients.


mangosteen peels extract; lymphocytes

Full Text:



Chen, S.-X., Wan, M. & Loh, B.-N., 1996. Active Constituents Against HIV-1 Protease from Garcinia mangostana. Planta Medica, 62(4), pp.381–382. Available at: [Accessed May 2, 2017].

Ghate, M. et al., 2011. Mortality in HIV infected individuals in Pune, India. The Indian journal of medical research, 133(4), pp.414–20. Available at: [Accessed May 2, 2017].

Jaruga, P. et al., 2002. Supplementation with antioxidant vitamins prevents oxidative modification of DNA in lymphocytes of HIV-infected patients. Free radical biology & medicine, 32(5), pp.414–20. Available at: [Accessed May 2, 2017].

Kameoka, M., Kimura, T. & Ikuta, K., 1993. Superoxide enhances the spread of HIV-1 infection by cell-to-cell transmission. FEBS Letters, 331(1–2), pp.182–186. Available at: [Accessed May 2, 2017].

Kaufmann, G.R. et al., 2003. CD4 T-Lymphocyte Recovery in Individuals With Advanced HIV-1 Infection Receiving Potent Antiretroviral Therapy for 4 Years<subtitle>The Swiss HIV Cohort Study</subtitle> Archives of Internal Medicine, 163(18), p.2187. Available at: [Accessed May 2, 2017].

Nakatani, K. et al., 2002. Inhibitions of histamine release and prostaglandin E2 synthesis by mangosteen, a Thai medicinal plant. Biological & pharmaceutical bulletin, 25(9), pp.1137–41. Available at: [Accessed May 2, 2017].

Swity, A.F., Setiabudi, D. & Garna, H., 2016. Korelasi Total Lymphocyte Count terhadap CD4 pada anak dengan Infeksi Human Immunodeficiency Virus. Sari Pediatri, 15(2), p.81. Available at: [Accessed May 2, 2017].


  • There are currently no refbacks.

Copyright (c) 2017 Jurnal NERS

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

This journal is indexed by:





This journal is published by:


          Faculty of Nursing Universitas Airlangga in Collaboration with Indonesian National Nurses Association


Creative Commons License

This journal (p-ISSN:1858-3598; e-ISSN:2502-5791) is licensed under a Creative Commons Attribution 4.0 International License


Current Stats

Previous Stats