THE IMPACT OF GREEN TEA ON BLOOD FLUIDITY IMPROVEMENT AND WEIGHT LOSS

green tea (-)-epigallocatechin gallate HPLC blood fluidity fructose-fed rat

Authors

  • Djoko Agus Purwanto
    djokoagus@ff.unair.ac.id
    Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Airlangga University, Campus B, Jl. Dharmawangsa Dalam, Surabaya 60286, Indonesia, Indonesia
  • Asri Darmawati Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Airlangga University, Campus B, Jl. Dharmawangsa Dalam, Surabaya 60286, Indonesia, Indonesia
  • purwaningsih purwaningsih Department of Fundamental Nursing, Faculty of Nursing, Airlangga University, Surabaya, Indonesia, Indonesia

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Introduction: Various studies have shown the benefi cial effects of green tea, not only on cardiovascular diseases but also on type 2 diabetes.

Methods: In this study, the preparation of green tea water extract has been standardized to (-)-epigalocatechin gallate (EGCG), the major component of green tea. The role of green tea water extract on blood fl uidity and diabetes diseases has been studied in 13 Fructose-Fed Rat (FFR). The rats were given high fructose diet ad libitum for one week and then combination with green tea water extract every day for 6 days.

Results: The results show, green tea water extract can reduces 100 μL blood passage times of wistar rat signifi cantly (p<0.01) by Micro-Channel Array Flow Analyzer (MC-FAN) instrument. Green tea water extract also had strong effect in reducing abdominal fat (p<0.05), blood glucose level (p<0.01) and body weight (p<0.01).

Conclusion: These results suggest that green tea water extract may has benefi cial effects for the treatment of diabetes and reduce blood viscosity.

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