Potential effect of green tea extract for adjuvant treatment of acute ischemic stroke by s100íŸ upregulation in non-thrombolysis patient
Downloads
Introduction: In ischemic stroke, the cerebral cortex suffers from hypoxia-ischemia, leading to inflammation and
oxidative stress. Green tea extract has an anti-inflammation effect and antioxidant. This study aimed to determine
the efficacy of green tea extract for adjuvant treatment of acute ischemic stroke in non-thrombolysis patients.
Methods: A double-blind randomised controlled trial was conducted in November 2020-November 2021. The
subjects were all acute ischemic stroke patients who presented to the Emergency Room during recruitment,
randomised into control (n=13) and intervention groups (n=18); the intervention groups were given green tea extract
350 mg. Treatment was for 30 days. National Institutes of Health Stroke Scale (NIHSS), modified Rankin Scale (mRS),
Montreal Cognitive Assessment - Indonesia (MoCAIna), IL-10 and S100íŸ were analysed.
Results: Data were compared with a significance level of p<0.05. The differences in NIHSS from day 0 to 7, day 0 to
14 and day 0 to 30 were statistically significant in the intervention group (p=0.019, p=0.002 and p=0.000, respectively).
The mRS score was statistically significant in the intervention group on day 30 (p=0.46). The differences in mRS score
from day 0 to 14 and day 0 to 30 were statistically significant (p=0.042 and p=0.001, respectively) The S100íŸ were
statistically significant in day 7 (p=0.006). The difference in S100íŸ from day 0 to 7 was statistically significant (p=0.001).Conclusions: The green tea extract, through up-regulation S100íŸ, can improve the clinical outcomes of acute
ischemic stroke.
Copyright (c) 2023 Jurnal Ners
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with Jurnal Ners agree to the following terms:
- Authors transfer the Copyright and grant Jurnal Ners the right of first publication with the work simultaneously licensed under a Creative Commons Attribution 4.0 International License that allows others to remix, adapt and build upon the work with an acknowledgment of the work's authorship and of the initial publication in Jurnal Ners.
- Authors are permitted to copy and redistribute the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in Jurnal Ners.
Jurnal Ners requires a formal written declaration and transfer of copyright from the author(s) for each article published. We, therefore, ask you to complete and return this form, retaining a copy for your own records. Your cooperation is essential and appreciated. Any delay will result in a delay in publication. The form can be downloaded HERE.
