ORGANIZING COVID-19 SURVIVORS AS CONVALESCENT PLASMA DONORS
Downloads
Introduction: Convalescent plasma transfusion therapy remains as one of the therapies recommended by the Ministry of Health for Covid-19 patients in Indonesia. However, in its practice, this therapy is greatly constrained by the availability of plasma donors at the Indonesian Red Cross (PMI) and the few survivors who are willing to donate their blood plasma. The aims of the community service activity were to educate, organize, and facilitate the survivors to do screening and donate their plasma.
Methods: The activities were conducted in June until December 2021, at Indrapura Field Hospital (RSLI) Surabaya. A total 925 participants (641 male and 309 female) were all Covid-19 patients from RSLI Surabaya. The demographic data were collected and organized as a database. The survivor's online communication group (16 WhatsApp groups) were created, to provide information and education about Covid-19 and the importance of plasma donation to the patients and survivors.
Results: The three largest groups by age were 26-35 (30.84%), 46-55 (21.26%), and 36-45 (19.47%) years old. The 3 largest groups by city of origin were Surabaya (62.42%), Sidoarjo (16.53%), and Gresik (8.63%). About 77.89% of participants have their understanding in the convalescent plasma for Covid-19. About 43.79% of them were willing to become donors after 14-day-recovery, and have been registered in the web application of donors. The 102 survivors were also involved in free plasma screening with PMI Surabaya. Total 88 survivors who have passed the screening have given their plasma as convalescent donors.
Conclusion: Organizing and educating Covid-19 survivors were exceptionally required to encourage them to become a plasma donor. The collected survivor data must be stored and managed properly to facilitate everything related to the blood plasma. The survivors are suggested to be screened 14 days after being declared healthy, to maintain the availability of blood plasma at PMI for Covid-19 patients who necessitate the convalescent plasma therapy.
Balcells, M. E., Rojas, L., Le Corre, N., Martínez-Valdebenito, C., Ceballos, M. E., Ferrés, M., Chang, M., Vizcaya, C., Mondaca, S., Huete, Á., Castro, R., Sarmiento, M., Villarroel, L., Pizarro, A., Ross, P., Santander, J., Lara, B., Ferrada, M., Vargas-Salas, S., ... Nervi, B. (2020). Early Anti-SARS-CoV-2 convalescent plasma in patients admitted for COVID-19: A randomized Phase II clinical trial. MedRxiv, 1–25. https://doi.org/10.1101/2020.09.17.20196212
Baskoro, S. (2021). Kebutuhan Tinggi dan Stok Menipis. Kontan.Co.Id.
Casadevall, A., Joyner, M. J., & Pirofski, L. A. (2020). SARS-CoV-2 viral load and antibody responses: The case for convalescent plasma therapy. Journal of Clinical Investigation, 130(10), 5112–5114. https://doi.org/10.1172/JCI139760
Duan, K., Liu, B., Li, C., Zhang, H., Yu, T., Qu, J., Zhou, M., Chen, L., Meng, S., Hu, Y., Peng, C., Yuan, M., Huang, J., Wang, Z., Yu, J., Gao, X., Wang, D., Yu, X., Li, L., ... Yang, X. (2020). Effectiveness of convalescent plasma therapy in severe COVID-19 patients. Proceedings of the National Academy of Sciences of the United States of America, 117(17), 9490–9496. https://doi.org/10.1073/pnas.2004168117
Elba, F., Daryanti, E., Poddar, S., & Shrestha, S. (2021). The effect of compliance of intake of fe tablets through the whatsapp group messenger program for pregnant women on the increase in Hb level at the Garuda Health Center, Bandung City. Malaysian Journal of Medicine and Health Sciences, 17(June), 132–136.
Epstein, J., & Burnouf, T. (2020). Points to consider in the preparation and transfusion of COVID-19 convalescent plasma. Vox Sanguinis, 115(6), 485–487. https://doi.org/10.1111/vox.12939
Gharbharan, A., Jordans, C. C. E., Geurtsvankessel, C., den Hollander, J. G., Karim, F., Mollema, F. P. N., Stalenhoef–Schukken, J. E., Dofferhoff, A., Ludwig, I., Koster, A., Hassing, R. J., Bos, J. C., van Pottelberge, G. R., Vlasveld, I. N., Ammerlaan, H. S. M., van Leeuwen–Segarceanu, E. M., Miedema, J., van der Eerden, M., Papageorgiou, G., ... Rijnders, B. J. A. (2020). Convalescent Plasma for COVID-19. A randomized clinical trial. MedRxiv, 1–16. https://doi.org/10.1101/2020.07.01.20139857
Kong, Y., Cai, C., Ling, L., Zeng, L., Wu, M., Wu, Y., Zhang, W., & Liu, Z. (2020). Successful treatment of a centenarian with coronavirus disease 2019 (COVID-19) using convalescent plasma. Transfusion and Apheresis Science, 59(5), 102820. https://doi.org/10.1016/j.transci.2020.102820
Korley, F. K., Durkalski-Mauldin, V., Yeatts, S. D., Schulman, K., Davenport, R. D., Dumont, L. J., El Kassar, N., Foster, L. D., Hah, J. M., Jaiswal, S., Kaplan, A., Lowell, E., McDyer, J. F., Quinn, J., Triulzi, D. J., Van Huysen, C., Stevenson, V. L. W., Yadav, K., Jones, C. W., ... SIREN-C3PO Investigators. (2021). Early Convalescent Plasma for High-Risk Outpatients with Covid-19. The New England Journal of Medicine, 1–11. https://doi.org/10.1056/NEJMoa2103784
Li, L., Tong, X., Chen, H., He, R., Lv, Q., Yang, R., Zhao, L., Wang, J., Xu, H., Liu, C., Chen, G., Chen, S., Li, C., Qiao, J., Yang, J., Wu, Y., & Liu, Z. (2020). Characteristics and serological patterns of COVID-19 convalescent plasma donors: optimal donors and timing of donation. Transfusion, 60(8), 1765–1772. https://doi.org/10.1111/trf.15918
Malani, A. N., Sherbeck, J. P., & Malani, P. N. (2020). Convalescent Plasma and COVID-19. JAMA - Journal of the American Medical Association, 324(5), 524. https://doi.org/10.1001/jama.2020.10699
Mario, A. D. (2021). Ada 2 Miliar Pengguna Aktif di WhatsApp Setiap Bulan. Liputan6. https://www.liputan6.com/tekno/read/4492694/ada-2-miliar-pengguna-aktif-di-whatsapp-setiap-bulan
Mo, H., Zeng, G., Ren, X., Li, H., Ke, C., Tan, Y., Cai, C., Lai, K., Chen, R., Chan-Yeung, M., & Zhong, N. (2006). Longitudinal profile of antibodies against SARS-coronavirus in SARS patients and their clinical significance. Respirology, 11(1), 49–53. https://doi.org/10.1111/j.1440-1843.2006.00783.x
Palang Merah Indonesia. (2021). PMI syarat donor. Unit Donor Darah Pusat PMI. http://utdp-pmi.or.id/berita/read/donor-plasma-konvalesen
Ray, Y., Paul, S. R., Bandopadhyay, P., D'Rozario, R., Sarif, J., Lahiri, A., Bhowmik, D., Vasudevan, J. S., Maurya, R., Kanakan, A., Sharma, S., Kumar, M., Singh, P., Roy, R., Chaudhury, K., Maiti, R., Bagchi, S., Maiti, A., Perwez, M. M., ... Ganguly, D. (2020). Clinical and immunological benefits of convalescent plasma therapy in severe COVID-19: insights from a single center open label randomised control trial. MedRxiv, 2020.11.25.20237883. http://medrxiv.org/content/early/2020/11/29/2020.11.25.20237883.abstract
Salazar, E., Christensen, P. A., Graviss, E. A., Nguyen, D. T., Castillo, B., Chen, J., Lopez, B. V., Eagar, T. N., Yi, X., Zhao, P., Rogers, J., Shehabeldin, A., Joseph, D., Leveque, C., Olsen, R. J., Bernard, D. W., Gollihar, J., & Musser, J. M. (2020). Treatment of Coronavirus Disease 2019 Patients with Convalescent Plasma Reveals a Signal of Significantly Decreased Mortality. American Journal of Pathology, 190(11), 2290–2303. https://doi.org/10.1016/j.ajpath.2020.08.001
Salazar, E., Christensen, P. A., Graviss, E. A., Nguyen, D. T., Castillo, B., Chen, J., Lopez, B. V., Eagar, T. N., Yi, X., Zhao, P., Rogers, J., Shehabeldin, A., Joseph, D., Masud, F., Leveque, C., Olsen, R. J., Bernard, D. W., Gollihar, J., & Musser, J. M. (2021). Significantly Decreased Mortality in a Large Cohort of Coronavirus Disease 2019 (COVID-19) Patients Transfused Early with Convalescent Plasma Containing High-Titer Anti–Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Spike Protein IgG. American Journal of Pathology, 191(1), 90–107. https://doi.org/10.1016/j.ajpath.2020.10.008
Satuan Tugas Penanganan. (2021). Analisis Data Covid-19 Indonesia. Update Per 27 Juni 2021.
Shrotri, M., Swinnen, T., Kampmann, B., & Parker, E. P. K. (2021). An interactive website tracking COVID-19 vaccine development. The Lancet Global Health, 9(5), e590–e592. https://doi.org/10.1016/S2214-109X(21)00043-7
Tworek, A., JaroÅ„, K., UszyÅ„ska-KaÅ‚uża, B., Rydzewski, A., Gil, R., DeptaÅ‚a, A., Franek, E., Wójtowicz, R., Å»yciÅ„ska, K., Walecka, I., Cicha, M., Wierzba, W., ZaczyÅ„ski, A., Król, Z. J., & Rydzewska, G. (2021). Convalescent plasma treatment is associated with lower mortality and better outcomes in high-risk COVID-19 patients – propensity-score matched case-control study. International Journal of Infectious Diseases, 105, 209–215. https://doi.org/10.1016/j.ijid.2021.02.054
Utami, R. B., Sari, U. S. C., & Sopianingsih, J. (2020). Jurnal Kebidanan Khatulistiwa Efektifitas Penggunaan Media Melalui Whatsapp Dan Booklet Kecamatan Benua Kayong Kabupaten Ketapang Effectiveness of Using Media Whatsapp and Booklet Against Asian Father Attitude in the Working Center of Health. Efektivitas Penggunaan Media Melalui Whatsapp Dan Booklet Terhadap Sikap Ayah ASI Di Wilayah Kerja Puskesmas Tuan Tuan Kecamatan Benua Kayong Kabupaten Ketapang, 6.
Copyright (c) 2022 Jurnal Pengabdian Masyarakat Dalam Kesehatan
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with Jurnal Pengabdian Masyarakat dalam Kesehatan agree to the following terms:
The journal allows the author to hold the copyright of the article without restrictions.
The journal allows the author(s) to retain publishing rights without restrictions
The legal formal aspect of journal publication accessibility refers to Creative Commons Attribution (CC BY).
Authors retain copyright and grant Jurnal Pengabdian Masyarakat dalam Kesehatan the right of first publication with the work simultaneously licensed under a Creative Commons Attribution 4.0 International License that allows others to remix, adapt and build upon the work with an acknowledgment of the work's authorship and of the initial publication in Jurnal Pengabdian Masyarakat dalam Kesehatan.
- Authors are permitted to copy and redistribute the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in Jurnal Pengabdian Masyarakat dalam Kesehatan.
Jurnal Pengabdian Masyarakat dalam Kesehatan requires a formal written declaration and transfer of copyright from the author(s) for each article published. We, therefore, ask you to complete and return this form, retaining a copy for your own records. Your cooperation is essential and appreciated. Any delay will result in a delay in publication.
JPMK by Unair is licensed under a Creative Commons Attribution 4.0 International License.