Impact of Duration of Untreated Psychosis on Cognitive Function in Schizophrenia

Rina Krismiati Gani, Erikavitri Yulianti, Ifa Tunisya

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Background: Schizophrenia is a chronic and serious clinical syndrome with very aggravating psychopathology involving perception, cognition, emotion, and behaviour. Currently, cognitive dysfunction is seen as a core disorder of schizophrenia. Duration of Untreated Psychosis (DUP) refers to the period from the onset of psychotic symptoms to the first adequate administration of antipsychotics.
Aims: This review aims to analyse the impact of DUP on cognitive function in schizophrenia.
Methods: PubMed and Google Scholar were searched using the following keyword: (cognitive function) and (neurodevelopmental OR neurotoxicity hypothesis) and (duration of untreated psychosis or DUP) and (schizophrenia or psychosis or psychotic) using the journal publication filter for the 2014-2020 issue. We also used textbooks published in the last 10 years and were related to writing themes.
Review: There are two different opinions about the impact of DUP on the cognitive function of schizophrenic patients: (1) the neurodevelopmental hypothesis says there is no impact of the length of DUP on the cognitive function of schizophrenic patients; (2) the neurotoxicity hypothesis says the length of the DUP will impact the patient's cognitive function. Despite differences of opinion about the impact of DUP on cognitive function in schizophrenia, early intervention in schizophrenic patients is important because DUP is associated with worse general disease symptoms, lower likelihood of remission, more severe positive and negative symptoms, and worse social functioning and overall outcomes.
Summary: There are differences of opinion about the impact of DUP on cognitive function in schizophrenic patients.


cognitive function, duration of untreated psychosis, schizophrenia

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R. A. Purwaningdyah, K. Jusuf, and N. Karmila, “Profil Penderita Akne Vulgaris pada Siswa-Siswi di SMA Shafiyyatul Amaliyyah Medan (Acne Vulgaris Patient Profiles of Shafiyyatul Amaliyyah Medan High School Students),” e-jurnal Fak. Kedokt. USU, vol. 1, no. 1, pp. 1–8, 2013.

M. Eyuboglu, I. Kalay, and D. Eyüboglu, “Evaluation of adolescents diagnosed with acne vulgaris for quality of life and psychosocial challenges,” Indian J. Dermatol., vol. 63, no. 2, pp. 131–135, 2018, doi: 10.4103/ijd.IJD_671_16.

E. Tasoula et al., “O impacto da acne vulgar na qualidade de vida e saúde psíquica em jovens adolescentes na grécia. resultados de uma pesquisa populacional,” An. Bras. Dermatol., vol. 87, no. 6, pp. 862–869, 2012, doi: 10.1590/S0365-05962012000600007.

G. N. Vilar, “Quality of life, self-esteem and psychosocial factors in adolescents with acne vulgaris,” An Bras Dermatol, vol. 90, no. 5, pp. 622–629, 2015, doi: 10.1590/abd1806-4841.201533726.

A. Djuanda, Ilmu Penyakit Kulit dan Kelamin, 6th ed. Jakarta: Fakultas Kedokteran Universitas Indonesia, pp. 9-35, 2017.

Sugiyono, Metode Penelitian: Kuantitatif, Kualitatif, dan R&D, 1st ed. Bandung: Alfabeta, pp. 100-120, 2019.

S. Cohen, T. Kamarck, and R. Mermelstein, “A global measure of perceived stress.,” J. Health Soc. Behav., vol. 24, no. 4, pp. 385–396, 1983, doi: 10.2307/2136404.

H. P. Lehmann, K. A. Robinson, J. S. Andrews, V. Holloway, and S. N. Goodman, “Acne therapy: A methodologic review,” J. Am. Acad. Dermatol., vol. 47, no. 2, pp. 231–240, 2002, doi: 10.1067/mjd.2002.120912.

B. McEwen and R. Sapolsky, “Stress and Your Health,” J. Clin. Endocrinol. Metab., vol. 91, no. 2, 2006, doi: 10.1210/jcem.91.2.9994.

J. Tanaka, “Pengaruh Tingkat Stres dengan Tingkat Keparahan Akne Vulgaris pada Siswa-Siswi Kelas III SMA Sutomo 2,” Repos. USU, 2018, [Online]. Available:

A. Thapar, S. Collishaw, D. S. Pine, and A. K. Thapar, “Depression in adolescence,” Lancet, vol. 379, no. 9820, pp. 1056–1067, 2012, doi: 10.1016/S0140-6736(11)60871-4.

V. A. Nauli, K. Karnadi, and S. M. Meilani, “Peran Ibu Pedagang Pasar 24 Jam Terhadap Perkembangan Moral Anak (Penelitian Studi Kasus di Kota Bekasi),” J. Obs. J. Pendidik. Anak Usia Dini, vol. 3, no. 1, p. 241, 2019, doi: 10.31004/obsesi.v3i1.179.

C. McNeely and J. Blanchard, The Teen Years Explained: A guide to Healthy Adolescent and Development. Baltimore: Center of Adolescent Health at the Johns Hopkins Bloomberg School of Public Health, pp. 4, 2009.

A. C. Aqsha et al., “Profil pemilihan dan penggunaan produk anti-jerawat yang tepat pada mahasiswa,” J. Farm. Komunitas, vol. 3, no. 1, pp. 18–22, 2016, [Online]. Available:

E. E. Ogedegbe and E. B. Henshaw, “Severity and impact of acne vulgaris on the quality of life of adolescents in Nigeria,” Clin. Cosmet. Investig. Dermatol., vol. 7, pp. 329–334, 2012, doi: 10.2147/CCID.S73302.

P. Jarrett, “Acne vulgaris,” Encyclopedia of Pharmacy Practice and Clinical Pharmacy, 2019. (accessed May 23, 2020).

R. N. Smith, N. J. Mann, A. Braue, H. Mäkeläinen, and G. A. Varigos, “A low-glycemic-load diet improves symptoms in acne vulgaris patients: A randomized controlled trial,” Am. J. Clin. Nutr., vol. 86, no. 1, pp. 107–115, 2007, doi: 10.1093/ajcn/86.1.107.

J. Rao, “Acne Vulgaris,” Medscape, 2020. (accessed Jun. 03, 2020).

Soewadi, Simtomatologi dalam Psikiatri. Yogyakarta: Percetakan MEDIKA FK UGM, pp. 14-17, 1999.

H. Kaplan, B. Sadock, and J. Grebb, Kaplan and Sadock’s Synopsis of Psychiatry: Behavioral Sciences Clinical Psychiatry, 7th ed., vol. 7, no. 11. Baltimore: Williams & Wilkins, pp. 2063-2073, 2994.

O. Revol, N. Milliez, and D. Gerard, “Psychological impact of acne on 21st-century adolescents: Decoding for better care,” Br. J. Dermatol., vol. 172, no. S1, pp. 52–58, 2015, doi: 10.1111/bjd.13749.

R. J. Lasek and M. M. Chren, “Acne vulgaris and the quality of life of adult dermatology patients,” Arch. Dermatol., vol. 134, no. 4, pp. 454–458, 1998, doi: 10.1001/archderm.134.4.454.

G. Karauwan, R. Rumende, and E. Makausi, “The Correlation Of Stress And Facial Hygiene With Acne Vulgaris Disease Of Nineth Grade Student In Tondano JHS,” E-Jurnal Sariputra. Univ. Sariputra Indones. Tomohon, vol. 4, no. 2, pp. 30–34, 2018, [Online]. Available:

D. Miranda, “Hubungan Tingkat Stres Dengan Kejadian Akne Vulgaris Pada Siswa Madrasah Aliyah Swasta Ar-Risalah Padang Tahun 2018,” Universitas Andalas, pp. 1-37, 2018.

A. Khan, “Acne and it’s associations with psychosocial well-being among adolescents in Nellore (India),” Lithuanian University of Health Sciences, Faculty of Public Health, pp. 1-40, 2017.


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