Hubungan Kadar Periostin Serum dan Nilai Asthma Control Test pada Pasien Asma di RSUD Dr. Soetomo Surabaya
[Periostin Serum Level and Asthma Control Test in Dr. Soetomo General Hospital Surabaya]
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Background: Asthma is a heterogenous disease composed of various phenotype. Chronic airway inflammation are fundamental features of asthma. The main treatment of asthma is corticosteroid. The administration of inhaled corticosteroids will reduce the inflammatory process in asthma. Even with adequate inhaled corticosteroid treatment, there are still patients who develop symptoms with lower asthma control test score. Periostin is an extracellular matrix protein as the best single systemic biomarker for assessing tissue eosinophilia, airway remodeling in uncontrolled asthma. The objective of this study was to examine whether serum periostin is correlated with ACT in asthmatic patients. Methods: This research was an observational analytical with cross sectional design conducted in outpatient clinic Dr. Soetomo General Hospital Surabaya for 3 months. In total, we found 40 asthmatic patients who were qualified to the inclusion and exclusion criteria as the research samples. The questionnaire was filled in to assess the Asthma Control Test and venous blood tests to measure serum periostin levels using Sandwich Enzyme-Linked Immunosorbent Assay (ELISA) method. Results: The mean periostin level profile of the sample was 94.82 ± 19.21 ng/ml and the median was 94.7 ng/ml. The average ACT score was 16.55 ± 2.93 with 85% were uncontrolled asthma. The results of the independent t-test showed serum periostin levels and the level of asthma control based on ACT score in asthmatics patients had a significant correlation (p = 0.024). Conclusion: There is a significant correlation between serum periostin levels and ACT score in asthmatic patients.
Asthma GIF. Global Strategy for Asthma Management and Prevention. Global Initiative for Asthma, 2017.
Shifren A, Witt C, Christie C and Castro M. Mechanisms of Remodeling in Asthmatic Airways. Journal of Allergy. 2012; 2012: 316049.
Indonesia BPDPKKKR. Riset Kesehatan Dasar: Riskesdas 2013. Jakarta: Kementerian Kesehatan Republik Indonesia, 2013.
Luhadia SK. Steroid Resistant Asthma. The Journal of The Association of Physicians of India. 2014; 62: 38-40.
Barnes PJ. Pathophysiology of Asthma. British Journal of Clinical Pharmacology. 1996; 42: 3-10.
Izuhara K, Matsumoto H, Ohta S, Ono J, Arima K and Ogawa M. Recent Developments Regarding Periostin in Bronchial Asthma. Allergology International : Official Journal of the Japanese Society of Allergology. 2015; 64 Suppl: S3-10.
Emprm V, Rajanandh MG and Nageswari AD. Periostin - A Novel Systemic Biomarker for Eosinophilic Airway Inflammation: A Case Control Study. J Clin Diagn Res. 2016; 10: Oc01-4.
Jia G, Erickson RW, Choy DF, et al. Periostin is a Systemic Biomarker of Eosinophilic Airway Inflammation in Asthmatic Patients. The Journal of Allergy and Clinical Immunology. 2012; 130: 647-54.E10.
Boushey H, Corry D and Fahy J. Asthma. In: Murray J, Nadel J and Mason R, (Eds.). Textbook of Respiratory Medicine. 3rd Edition Ed. Philadelphia: W.B. Saunders Company, 2004, P. 1168-216.
Fingleton J, Braithwaite I, Travers J, et al. Serum Periostin in Obstructive Airways Disease. The European Respiratory Journal. 2016; 47: 1383-91.
Thomas M, Kay S, Pike J, et al. The Asthma Control Test (ACT) as a Predictor of Gina Guideline-Defined Asthma Control: Analysis of a Multinational Cross-Sectional Survey. Primary Care Respiratory Journal : Journal of the General Practice Airways Group. 2009; 18: 41-9.
Weis S and Apter J. Asthma. In: Fishman A, Elias J and Grippi M, (Eds.). Fishman's Pulmonary Disease and Disorders. 4th Edition Ed. New York: McGraw-Hill Companies, 2008, P. 787-8.
De Nijs SB, Venekamp LN and Bel EH. Adult-Onset Asthma: Is It Really Different? European Respiratory Review : An Official Journal of the European Respiratory Society. 2013; 22: 44-52.
Atmoko W, Faisal HKP, Bobian ET, Adisworo MW and Yunus F. Prevalens Asma Tidak Terkontrol dan Faktor-Faktor yang Berhubungan dengan Tingkat Kontrol Asma di Poliklinik Asma Rumah Sakit Persahabatan, Jakarta. Jurnal Respirologi Indonesia. 2011; 31: 53-60.
Chhabra SK. Assessment of Control in Asthma: The New Focus in Management. The Indian Journal of Chest Diseases & Allied Sciences. 2008; 50: 109-16.
Matsusaka M, Kabata H, Fukunaga K, et al. Phenotype of Asthma Related with High Serum Periostin Levels. Allergology International : Official Journal of the Japanese Society of Allergology. 2015; 64: 175-80.
Amin MM, Khattab MA, Hassan SA and Sattar HAA. Serum Periostin as a Unique Biomarker of Bronchial Asthma. Medical Journal of Cairo University. 2017; 85: 3285-93.
McSharry C and Johnstone S. Periostin as a Biomarker of Airway Inflammation. Polskie Archiwum Medycyny Wewnetrznej. 2016; 126: 118-20.
ílvarez-Gutiérrez FJ, Medina-Gallardo JF, Pérez-Navarro P, et al. Relationship of the Asthma Control Test (ACT) with Lung Function, Levels of Exhaled Nitric Oxide and Control According to the Global Initiative for Asthma (Gina). Archivos de Bronconeumología ((English Edition)). 2010; 46: 370-7.
Ilyas M, Yunus F and Wiyono WH. Correlation between Asthma Control Test (ACT) and Spirometry as Tool of Assessing of Controlled Asthma. Jurnal Respirologi Indonesia. 2010; 30: 190-6.
Nguyen VN, Chavannes N, Le LT and Price D. The Asthma Control Test (ACT) as an Alternative Tool to Global Initiative for Asthma (GINA) Guideline Criteria for Assessing Asthma Control in Vietnamese Outpatients. Primary Care Respiratory Journal : Journal of the General Practice Airways Group. 2012; 21: 85-9.
Simpson JL, Yang IA, Upham JW, et al. Periostin Levels and Eosinophilic Inflammation in Poorly-Controlled Asthma. BMC Pulmonary Medicine. 2016; 16: 67.
Kanemitsu Y, Matsumoto H, Izuhara K, et al. Increased Periostin Associates with Greater Airflow Limitation in Patients Receiving Inhaled Corticosteroids. The Journal of Allergy and Clinical Immunology. 2013; 132: 305-12.E3.
Schatz M, Sorkness CA, Li JT, et al. Asthma Control Test: Reliability, Validity, and Responsiveness in Patients Not Previously Followed by Asthma Specialists. The Journal of Allergy And Clinical Immunology. 2006; 117: 549-56.
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