Association of IL-6 rs1800796 Gene Polymorphism on Susceptibility to Pulmonary Tuberculosis
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Introduction: IL-6 is a pro-inflammatory cytokine controlling the immune response to TB. This study investigated the association of IL-6 rs1800796 gene polymorphism on susceptibility to pulmonary TB.
Methods: The case-control study involved 71 cases and 34 controls. Blood samples were taken from all study participants at Dr. Saiful Anwar General Hospital, Malang, between August 2020 and February 2021. Blood samples were used in a genotyping investigation to determine SNPs using the PCR-Multiplex technique.
Results: The genotype association of IL-6 rs1800796 (G/G, G/C, C/C) and allele frequency for patients and controls of IL-6 rs1800796 with susceptibility to pulmonary TB were insignificant (p > 0.05).
Conclusion: This study found no evidence of an association of IL-6 rs1800796 gene polymorphism with susceptibility to pulmonary TB.
WHO. Global Tuberculosis Report 2020. Geneva, 2020. [Cited 2020 Oct 30]. Available from [WebPage]
Kementerian Kesehatan Republik Indonesia. Keputusan Menteri Kesehatan Republik Indonesia Nomor HK.01.07/MENKES/755/2019 tentang Pedoman Nasional Pelayanan Kedokteran Tata Laksana Tuberkulosis. HK.01.07/MENKES/755/ 2019, Indonesia, 2019.
Singh PP, Goyal A. Interleukin-6: A Potent Biomarker of Mycobacterial Infection. Springerplus 2013; 2: 686. [PubMed]
AL-Saad NF, Alsaadi MAK, Al-saadi AH. Association of IL-4 and IL-6 Gene Polymorphism with Pulmonary Tuberculosis. Eur J Mol Clin Med 2020; 7: 75–81. [WebPage]
Sudbury EL, Clifford V, Messina NL, et al. Mycobacterium tuberculosis-Specific Cytokine Biomarkers to Differentiate Active TB and LTBI: A Systematic Review. J Infect 2020; 81: 873–881. [PubMed] [CrossRef]
He C, Liu L. Associations of Polymorphisms in IL-6 and IL-18 with Tuberculosis: Evidence from a Meta Analysis. Microb Pathog 2020; 139: 103823. [PubMed] [CrossRef]
Wang H, Pang C, Zeng N, et al. Association between the IL-6 Gene Polymorphism and Tuberculosis Risk: A Meta-Analysis. Infect Drug Resist 2017; 10: 445–454. [PubMed] [CrossRef]
Al-Husseini A-H, Muhammed R. The Association between Genetic Polymorphisms of II-6 Gene and Susceptibility of Systemic Lupus Erythematosus in Iraqi Population. EurAsian J Biosci 2020; 14: 2559–2567. [ProQuest]
Mao Z-R, Zhang S-L, Feng B. Association of IL-10 (-819T/C, -592A/C and -1082A/G) and IL-6 -174G/C Gene Polymorphism and the Risk of Pneumonia-Induced Sepsis. Biomarkers 2017; 22: 106–112. [CrossRef]
Zhang T, Wang Z, Xiao W. A Meta-Analysis of Interleukin-6 -572G>C Polymorphism and Coronary Heart Disease Susceptibility. Cardiology Journal 2017; 24: 107–110. [CrossRef]
Sun Y, Wang M. Association between IL-6 Gene Polymorphisms and Susceptibility of Tuberculosis: Evidence based on a Meta-Analysis. Int J Clin Exp Med 2017; 10: 4297–4304. [CrossRef]
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