The Impact of COVID-19 on Birth Weight during Pregnancy
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Introduction: Coronavirus is a viral pathogen that can be transmitted through respiratory droplets, leading to severe infectious diseases. This study aimed to ascertain the influence of the COVID-19 pandemic on birth weight during pregnancy.
Methods: This study used secondary data and a retrospective case-control approach for observational analysis. The case and control groups each had 153 samples. The case group was further separated into symptomatic and asymptomatic categories. Statistical analyses were performed to determine how COVID-19 infection in pregnant women affected birth weight. Fisher's exact test was used to evaluate data for the subgroups of asymptomatic and symptomatic individuals, while the Mann-Whitney test was used to compare the infection's impact.
Results: Most participants were 21–35 years old (78.2%). The findings showed that 85% of pregnant COVID-19 patients were in their third trimester. Mothers diagnosed with COVID-19 had infants with birth weights of >4,000 grams (3.3%), 2,500–4,000 grams (43.1%), and <2,500 grams (53.6%). Birth weight distribution in women unaffected by COVID-19 was >4,000 grams (14.4%), 2,500–4,000 grams (67.3%), and <2,500 grams (18.3%). The Mann-Whitney statistical test was performed using SPSS. It yielded a p-value of 0.001, less than the significance level of 0.05, indicating a correlation between confirmed COVID-19 infection in pregnant women and birth weight.
Conclusion: This study found that the presence of COVID-19 infection during pregnancy significantly affects infants' birth weight.
(WHO) WHO. COVID-19 Explorer. Geneva, https://worldhealthorg.shinyapps.io/covid/ (2021).
(WHO) WHO. Archived: WHO Timeline - COVID-19. Geneva, https://www.who.int/news/item/27-04-2020-who-timeline---covid-19 (2020).
Wu Y-C, Chen C-S, Chan Y-J. The Outbreak of COVID-19: An Overview. J Chin Med Assoc 2020; 83: 217–220.
Zhang H, Penninger JM, Li Y, et al. Angiotensin-Converting Enzyme 2 (ACE2) as a SARS-CoV-2 Receptor: Molecular Mechanisms and Potential Therapeutic Target. Intensive Care Med 2020; 46: 586–590.
Harapan H, Itoh N, Yufika A, et al. Coronavirus Disease 2019 (COVID-19): A Literature Review. J Infect Public Health 2020; 13: 667–673.
Yu W, Hu X, Cao B. Viral Infections during Pregnancy: The Big Challenge Threatening Maternal and Fetal Health. Matern Med (Wolters Kluwer Heal Inc) 2022; 4: 72–86.
Jin Y, Yang H, Ji W, et al. Virology, Epidemiology, Pathogenesis, and Control of COVID-19. Viruses; 12. Epub ahead of print March 2020.
Cavalcante MB, Cavalcante CT de MB, Sarno M, et al. Maternal Immune Responses and Obstetrical Outcomes of Pregnant Women with COVID-19 and Possible Health Risks of Offspring. J Reprod Immunol 2021; 143: 103250.
Jacob L, Koyanagi A, Smith L, et al. Prevalence of and Factors associated with COVID-19 Diagnosis in Symptomatic Patients Followed in General Practices in Germany between March 2020 and March 2021. Int J Infect Dis 2021; 111: 37–42.
Fan VS, Dominitz JA, Eastment MC, et al. Risk Factors for Testing Positive for Severe Acute Respiratory Syndrome Coronavirus 2 in a National United States Healthcare System. Clin Infect Dis 2021; 73: e3085–e3094.
Abbas AK, Lichtman AH, Pillai S. Cellular and Molecular Immunology. Elsevier Health Sciences, https://books.google.co.id/books?id=L4FUDgAAQBAJ (2017).
Zhang A, Stacey HD, Mullarkey CE, et al. Original Antigenic Sin: How First Exposure Shapes Lifelong Anti-Influenza Virus Immune Responses. J Immunol 2019; 202: 335–340.
Jí¸rgensen N, Persson G, Hviid TVF. The Tolerogenic Function of Regulatory T Cells in Pregnancy and Cancer. Front Immunol 2019; 10: 911.
Lu-Culligan A, Chavan AR, Vijayakumar P, et al. SARS-CoV-2 Infection in Pregnancy is associated with Robust Inflammatory Response at the Maternal-Fetal Interface. medRxiv : The Preprint Server for Health Sciences. Epub ahead of print January 2021.
Aggarwal R, Jain AK, Mittal P, et al. Association of Pro- and Anti-Inflammatory Cytokines in Preeclampsia. J Clin Lab Anal 2019; 33: e22834.
Negishi Y, Shima Y, Takeshita T, et al. Harmful and Beneficial Effects of Inflammatory Response on Reproduction: Sterile and Pathogen-Associated Inflammation. Immunol Med 2021; 44: 98–115.
Ragsdale HB, Kuzawa CW, Borja JB, et al. Regulation of Inflammation during Gestation and Birth Outcomes: Inflammatory Cytokine Balance Predicts Birth Weight and Length. Am J Hum Biol 2019; 31: e23245.
Muyayalo KP, Huang D-H, Zhao S-J, et al. COVID-19 and Treg/Th17 Imbalance: Potential Relationship to Pregnancy Outcomes. Am J Reprod Immunol 2020; 84: e13304.
Leveno KJ, Spong CY, Dashe JS, et al. Williams Obstetrics. 25th ed. McGraw-Hill Education, https://books.google.co.id/books?id=mhOdAQAACAAJ (2018).
Yockey LJ, Iwasaki A. Interferons and Proinflammatory Cytokines in Pregnancy and Fetal Development. Immunity 2018; 49: 397–412.
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