Omega-6 and Omega-3 Intake Ratio in Pulmonary Tuberculosis Patients and Its Correlation with Depression Score

Depression Omega-6/omega-3 ratio Tuberculosis


September 30, 2023


Introduction: Depression affects 45.19% of pulmonary tuberculosis (TB) patients' adherence to treatment, resulting in increased morbidity and death, medication resistance, and continued disease transmission. This study aimed to examine the relationship between omega-6/omega-3 (ꞷ-6/ꞷ-3) polyunsaturated fatty acids (PUFA) intake ratio and depression score in patients with pulmonary TB at Persahabatan National Respiratory Referral Hospital, Jakarta.

Methods: This was a cross-sectional study of 99 subjects with pulmonary TB. Data were collected using the Semi-Quantitative Food Frequency Questionnaire (SQ-FFQ), anthropometric measurements, and the Beck Depression Inventory-II (BDI-II).

Results: Correlation analysis used the Spearman test and revealed the ratio of ꞷ-6/ꞷ-3 PUFAs intake of 7.78 ± 1.13, the median value of depression score was 9 (10-36). There was no correlation between ꞷ-6/ꞷ-3 PUFA intake and depression score (r = 0.063; p = 0.534).

Conclusion: There was no correlation between ꞷ-6/ꞷ-3 PUFAs intake ratio and depression scores in pulmonary TB patients. This is the first study to examine the correlation between ꞷ-6/ꞷ-3 PUFA intake ratio and depression score in pulmonary TB patients.

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