Anosmia, Dysgeusia, and Comorbidity in COVID-19 Patients with Respiratory Tract Manifestations
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Introduction: Olfactory and special sensory disturbances such as anosmia and dysgeusia have been found among COVID-19 patients. These manifestations may cause post-covid sequelae, disturbing patients' quality of life who have recovered from COVID-19. This study aimed to analyze the association between anosmia and dysgeusia with the comorbidities in adult COVID-19 patients admitted to Dr. Soetomo General Hospital, Surabaya, from 1 January 2020 to 30 September 2021.
Methods: This was a cross-sectional retrospective analysis study based on the medical records of all patients who met the criteria (n = 158). The minimal age inclusion was 18 years old, and the patient must be positively diagnosed with COVID-19 (reverse transcription polymerase chain reaction/RT-PCR).
Results: Out of 158 patients, all had a fever, and approximately 93% of patients showed respiratory signs and symptoms. There were 128 patients (81%) who suffered from anosmia, and 15 patients (9.5%) had dysgeusia. Significant associations were found between anosmia with dysgeusia (p = 0.049) and between anosmia with cough (p = 0.003) and dyspnea (p = 0.000). The predominant comorbidities reported were overweight (60%), hypertension (42%), and type-2 diabetes mellitus (37%).
Conclusion: There were significant associations between anosmia with dysgeusia and the respiratory tract signs and symptoms instead of the comorbidities reported.
Cortinovis M, Perico N, Remuzzi G. Long-Term Follow-Up of Recovered Patients with COVID-19. Lancet (London, England) 2021; 397: 173–175.
Hassan SA, Sheikh FN, Jamal S, et al. Coronavirus (COVID-19): A Review of Clinical Features, Diagnosis, and Treatment. Cureus 2020; 12: e7355.
Alonso-Lana S, Marquié M, Ruiz A, et al. Cognitive and Neuropsychiatric Manifestations of COVID-19 and Effects on Elderly Individuals with Dementia. Front Aging Neurosci 2020; 12: 588872.
Banerjee D, Viswanath B. Neuropsychiatric Manifestations of COVID-19 and Possible Pathogenic Mechanisms: Insights from Other Coronaviruses. Asian J Psychiatr 2020; 54: 102350.
Xing J, Sun N, Xu J, et al. Study of the Mental Health Status of Medical Personnel Dealing with New Coronavirus Pneumonia. PLoS One 2020; 15: e0233145.
Mutiawati E, Fahriani M, Mamada SS, et al. Anosmia and Dysgeusia in SARS-CoV-2 Infection: Incidence and Effects on COVID-19 Severity and Mortality, and the Possible Pathobiology Mechanisms - A Systematic Review and Meta-Analysis. F1000Research 2021; 10: 40.
Meng X, Deng Y, Dai Z, et al. COVID-19 and Anosmia: A Review based on Up-to-Date Knowledge. Am J Otolaryngol 2020; 41: 102581.
Koul D, Begh RA, Kalsotra P. Olfactory and Gustatory Alterations in COVID-19 Patients: A Tertiary Care COVID-19 Centre Inpatient Experience. Indian J Otolaryngol Head Neck Surg 2022; 74: 2857–2861.
Krishnakumar HN, Momtaz DA, Sherwani A, et al. Pathogenesis and Progression of Anosmia and Dysgeusia during the COVID-19 Pandemic. Eur Arch Oto-Rhino-Laryngology Off J Eur Fed Oto-Rhino-Laryngological Soc Affil with Ger Soc Oto-Rhino-Laryngology - Head Neck Surg 2023; 280: 505–509.
Mattioli F, Stampatori C, Righetti F, et al. Neurological and Cognitive Sequelae of COVID-19: A Four Month Follow-Up. J Neurol 2021; 268: 4422–4428.
Unger T, Borghi C, Charchar F, et al. 2020 International Society of Hypertension Global Hypertension Practice Guidelines. Hypertens (Dallas, Tex 1979) 2020; 75: 1334–1357.
Lim JU, Lee JH, Kim JS, et al. Comparison of World Health Organization and Asia-Pacific Body Mass Index Classifications in COPD Patients. Int J Chron Obstruct Pulmon Dis 2017; 12: 2465–2475.
Lozada-Nur F, Chainani-Wu N, Fortuna G, et al. Dysgeusia in COVID-19: Possible Mechanisms and Implications. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 2020; 130: 344–346.
Paranhos ACM, Dias ÁRN, da Silva LCM, et al. Sociodemographic Characteristics and Comorbidities of Patients with Long COVID and Persistent Olfactory Dysfunction. JAMA Netw open 2022; 5: e2230637.
Butowt R, von Bartheld CS. Anosmia in COVID-19: Underlying Mechanisms and Assessment of an Olfactory Route to Brain Infection. Neuroscientist 2021; 27: 582–603.
Carrillo-Larco RM, Altez-Fernandez C. Anosmia and Dysgeusia in COVID-19: A Systematic Review. Wellcome Open Research 2020; 5: 94.
Whitcroft KL, Hummel T. Olfactory Dysfunction in COVID-19: Diagnosis and Management. JAMA 2020; 323: 2512–2514.
Guan W-J, Liang W-H, Zhao Y, et al. Comorbidity and Its Impact on 1590 Patients with COVID-19 in China: A Nationwide Analysis. Eur Respir J; 55. Epub ahead of print May 2020.
Sanyaolu A, Okorie C, Marinkovic A, et al. Comorbidity and Its Impact on Patients with COVID-19. SN Compr Clin Med 2020; 2: 1069–1076.
Hadi U, Bramanton B, Asmarawati TP, et al. Predictor of Mortality COVID-19 in Two Referral Hospital in Surabaya, Indonesia. Indian J Forensic Med Toxicol 2021; 16: 1203–1209.
Khan AS, Hichami A, Khan NA. Obesity and COVID-19: Oro-Naso-Sensory Perception. J Clin Med; 9. Epub ahead of print July 2020.
Dugail I, Amri E-Z, Vitale N. High Prevalence for Obesity in Severe COVID-19: Possible Links and Perspectives towards Patient Stratification. Biochimie 2020; 179: 257–265.
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