Assessment of Quality of Life in Advanced-Stage Lung Cancer Patients Using EORTC QLQ-C30 Questionnaire
Downloads
Introduction: Quality of life (QoL) is a multidomain concept that assesses a person through health status, functional status, and symptoms. The patient's QoL is greatly reduced due to the course of disease, severity of symptoms, and side effects of chemotherapy treatment. This study aimed to assess the QoL in advanced lung cancer patients using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-C30 (EORTC QLQ-C30).
Methods: This descriptive and observational study was conducted at the Pulmonary Polyclinic, Prof. Dr. Chairuddin Panusunan Lubis Universitas Sumatera Utara (USU) Hospital from February to July 2024, with a cross-sectional design using patient medical records and EORTC QLQ-C30 questionnaire. The EORTC QLQ-C30 questionnaire was analyzed with a score formula and categorized as good, moderate, and bad. The sample was 100 lung cancer patients using a purposive sampling technique according to the criteria.
Results: The results showed that almost all QoL was in the moderate category (80%). The general health status was mostly in the moderate category (61.66%), the functional status was mostly in the good category (75.35%), and the symptoms were in the moderate category (35.65%). In the functional scale, the role domain had the lowest mean, 69.99 ± 29.43. In the symptoms scale, the pain domain had the highest mean, 52.66 ± 29.43.
Conclusion: The overall QoL of lung cancer patients was in the moderate category, lower than the healthy population. It needs to be improved, especially in the role domain, by providing supportive-expressive group therapy.
Gonzalez L, Bardach A, Palacios A, et al. Health-Related Quality of Life in Patients with Breast Cancer in Latin America and the Caribbean: A Systematic Review and Meta-Analysis. Oncologist 2021; 26: e794–e806. [PubMed]
Pergolotti M, Deal AM, Williams GR, et al. Activities, Function, and Health-Related Quality of Life (HRQOL) of Older Adults with Cancer. J Geriatr Oncol 2017; 8: 249–254. [PubMed]
Sung H, Ferlay J, Siegel RL, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin 2021; 71: 209–249. [PubMed]
John LD. Self-Care Strategies Used by Patients with Lung Cancer to Promote Quality of Life. Oncol Nurs Forum 2010; 37: 339–347. [PubMed]
Polanski J, Jankowska-Polanska B, Rosinczuk J, et al. Quality of Life of Patients with Lung Cancer. Onco Targets Ther 2016; 9: 1023–1028. [PubMed]
Pusat Kajian Jaminan Sosial Universitas Indonesia (PKJS-UI). Kanker Paru, Kanker Paling Mematikan di Indonesia: Apa Saja yang telah Kita Atasi dan Apa yang Kita Bisa Lakukan. Jakarta, https://pkjsui.org/wp-content/uploads/2021/05/PKJS-UI_Dialog-Pemangku-Kepentingan-Kanker-Paru.pdf (2021).
Suhardin S, Kusnanto K, Krisnana I. Acceptance and Commitment Therapy (ACT) Meningkatkan Kualitas Hidup Pasien Kanker. J Ners 2016; 11: 118–127. [Journal]
Hassen AM, Taye G, Gizaw M, et al. Quality of Life and Associated Factors among Patients with Breast Cancer under Chemotherapy at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia. PLoS One 2019; 14: e0222629. [PubMed]
Anggraini RD. Hubungan Status Bekerja dengan Kualitas Hidup Lansia sebagai Kepala Keluarga di Wilayah Kerja Puskesmas Sembayat Gresik. Universitas Airlangga Surabaya, https://repository.unair.ac.id/84879/ (2019).
Noviyani R, Tunas IK, Indrayathi P, et al. Validity and Reliability of EORTC QLQ C-30 Questionnaire in Assessing Quality of Life of Gynecological Cancer Patients in Sanglah Hospital Denpasar. Indones J Clin Pharm 2016; 5: 106–114. [ResearchGate]
Witwaranukool P, Seedadard R, Krongthaeo S, et al. Quality of Life and Associated Factors among Cancer Patients Receiving Chemotherapy during the COVID-19 Pandemic in Thailand. International Journal of Environmental Research and Public Health; 21. Epub ahead of print 2024. [ResearchGate]
Koch M, Rasch F, Rothammer T, et al. Gender Differences in Quality of Life of Metastatic Lung Cancer Patients. Cancer Manag Res 2022; 14: 2971–2977. [PubMed]
Bray F, Ferlay J, Soerjomataram I, et al. Global Cancer Statistics 2018: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin 2018; 68: 394–424. [PubMed]
Soeroso NN, Ananda FR, Sitanggang JS, et al. The Role of Oncogenes and Tumor Suppressor Genes in Determining Survival Rates of Lung Cancer Patients in the Population of North Sumatra, Indonesia. F1000Research 2022; 11: 853. [PubMed]
Senorita S, Ermayanti S, Afriani A. Adenoskuamosa Paru dengan Metastasis Milier. Hum Care 2022; 7: 115–121. [Journal]
Stabellini N, Bruno DS, Dmukauskas M, et al. Sex Differences in Lung Cancer Treatment and Outcomes at a Large Hybrid Academic-Community Practice. JTO Clin Res Reports 2022; 3: 100307. [PubMed]
Sihombing F. Hubungan Tingkat Pendidikan Formal dengan Tingkat Pengetahuan Wanita tentang Kanker Payudara. EMBRIO 2021; 12: 126–139. [ResearchGate]
Wu Y, Ai Z, Xu G. Marital Status and Survival in Patients with Non-Small Cell Lung Cancer: An Analysis of 70006 Patients in the SEER Database. Oncotarget 2017; 8: 103518–103534. [PubMed]
Wu Y, Zhu PZ, Chen YQ, et al. Relationship between Marital Status and Survival in Patients with Lung Adenocarcinoma: A SEER-Based Study. Medicine (Baltimore) 2022; 101: e28492. [PubMed]
Hardiano R, Huda N, Studi P, et al. Gambaran Indeks Massa Tubuh pada Pasien Kanker yang Menjalani Kemoterapi. J Online Mhs Bid Ilmu Keperawatan 2016; 2: 1381–1388. [ResearchGate]
McQuade JL, Daniel CR, Hess KR, et al. Association of Body-Mass Index and Outcomes in Patients with Metastatic Melanoma Treated with Targeted Therapy, Immunotherapy, or Chemotherapy: A Retrospective, Multicohort Analysis. Lancet Oncol 2018; 19: 310–322. [PubMed]
Roy S, Vallepu S, Barrios C, et al. Comparison of Comorbid Conditions between Cancer Survivors and Age-Matched Patients without Cancer. J Clin Med Res 2018; 10: 911–919. [PubMed]
Coebergh JW, Janssen-Heijnen ML, Post PN, et al. Serious Co-Morbidity among Unselected Cancer Patients Newly Diagnosed in the Southeastern Part of The Netherlands in 1993-1996. J Clin Epidemiol 1999; 52: 1131–1136. [PubMed]
Niksic M, Redondo-Sanchez D, Chang YL, et al. The Role of Multimorbidity in Short-Term Mortality of Lung Cancer Patients in Spain: A Population-Based Cohort Study. BMC Cancer 2021; 21: 1048. [PubMed]
Jannah M, Kamal A, Amalia R. Kualitas Hidup Pasien Kanker Payudara yang Menjalani Kemoterapi di Rumah Sakit Umum Banda Aceh. J Ilm Mhs Keperawatan 2022; 6: 92–98. [Journal]
Karczmarek-Borowska B, Pelc M, Rabiej E, et al. The Quality of Life of Non-Small Cell Lung Cancer Patients Treated with Chemotherapy. Pneumonol Alergol Pol 2014; 82: 349–357. [PubMed]
American Cancer Society. Treatment Choices for Non-Small Cell Lung Cancer, by Stage. American Cancer Society, https://www.cancer.org/cancer/types/lung-cancer/treating-non-small-cell/by-stage.html (2024, accessed 27 August 2024).
Petrosyan F, Daw H, Haddad A, et al. Targeted Therapy for Lung Cancer. Anticancer Drugs 2012; 23: 1016–1021. [PubMed]
Soeroso NN, Zain-Hamid R, Sinaga B, et al. Genetic Polymorphism of CYP2A6 and Its Relationship with Nicotine Metabolism in Male Bataknese Smokers Suffered from Lung Cancer in Indonesia. Open Access Maced J Med Sci 2018; 6: 1199–1205. [PubMed]
Malik PS, Sharma MC, Mohanti BK, et al. Clinico-Pathological Profile of Lung Cancer at AIIMS: A Changing Paradigm in India. Asian Pac J Cancer Prev 2013; 14: 489–494. [PubMed]
Reynaldi A, Trisyani Y, Adiningsih D. Gambaran Kualitas Hidup Pasien Kanker Paru Stadium Lanjut di RS Paru Dr. H. A. Rotinsulu Bandung. J Nurs Care; 3. Epub ahead of print 23 June 2020. [Journal]
Susilowati YA. Faktor-Faktor yang Mempengaruhi Kualitas Hidup pada Survivor Kanker Payudara. Universitas Indonesia Jakarta, https://lib.ui.ac.id/m/detail.jsp?id=20389846&lokasi=lokal (2014).
Putri DSR, Utami M, Fitriana RN, et al. Dukungan Keluarga dapat Berpengaruh pada Kualitas Hidup Pasien Kanker Paru yang Menjalani Kemoterapi. J Adv Nurs Heal Sci 2023; 4: 16–24. [Journal]
Imas M, Nauri A. Metodologi Penelitian Kesehatan. Jakarta: Badan Pengembangan dan Pemberdayaan Sumber Daya Manusia Kesehatan, 2018.
Hakim R, Baskoro TA, Rusmariana A, et al. Hubungan Dukungan Keluarga dengan Kualitas Hidup Pasien Kanker yang Menjalani Kemoterapi di RSUD Keraton Pekalongan. J Online Mhs Fak Kedokt Univ Riau; 4, https://jom.unri.ac.id/index.php/JOMFDOK/article/download/13103/12732 (2017).
Agustini D, Surahman E, Abdulah R. Quality of Life Patients with Breast Cancer Therapy Combination Fluorouracil, Doxorubicin, and Cyclofosfamide. Indones J Clin Pharm; 4. Epub ahead of print 1 September 2015. [ResearchGate]
Butow PN, Price MA, Bell ML, et al. Caring for Women with Ovarian Cancer in the Last Year of Life: A Longitudinal Study of Caregiver Quality of Life, Distress and Unmet Needs. Gynecol Oncol 2014; 132: 690–697. [PubMed]
Putri RH. Kualitas Hidup Pasien Kanker Ginekologi yang Menjalani Terapi. J Aisyah J Ilmu Kesehatan; Vol 2, No 1 June. Epub ahead of print 2017. [Journal]
American Cancer Society. Peripheral Neuropathy. American Cancer Society, https://www.cancer.org/cancer/managing-cancer/side-effects/pain/peripheral-neuropathy.html (2015, accessed 12 December 2015).
Baehaqi R. Hubungan antara Jumlah Leukosit dan Skor Karnofsky pada Pasien Kanker Paru. Universitas Diponegoro, http://eprints.undip.ac.id/37772/1/Ronald_Baehaqi_G2A008169_Lap.KTI.pdf (2012).
Heydarnejad MS, Hassanpour DA, Solati DK. Factors Affecting Quality of Life in Cancer Patients undergoing Chemotherapy. Afr Health Sci 2011; 11: 266–270. [PubMed]
Husen A, Suharti C, Hardian H. Hubungan antara Derajat Nyeri dengan Tingkat Kualitas Hidup Pasien Kanker Paru yang Menjalani Kemoterapi. J Kedokt Diponegoro 2016; 5: 545–557. [Journal]
Copyright (c) 2024 Ariantika Ariantika, Rahayu Lubis, Asfriyati Asfriyati, Taufik Ashar, Nurmaini Nurmaini, Noni Novisari Soeroso, Kamal Basri Siregar, Darren Wan-Teck Lim
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
1. The journal allows the author to hold the copyright of the article without restrictions.
2. The journal allows the author(s) to retain publishing rights without restrictions.
3. The legal formal aspect of journal publication accessibility refers to Creative Commons Attribution Share-Alike (CC BY-SA).
4. The Creative Commons Attribution Share-Alike (CC BY-SA) license allows re-distribution and re-use of a licensed work on the conditions that the creator is appropriately credited and that any derivative work is made available under "the same, similar or a compatible license”. Other than the conditions mentioned above, the editorial board is not responsible for copyright violation.
JR (