The Influence of Nigella sativa on the Increase of IFN-γ and Quality of Life in Lung Cancer Patients Undergoing Chemotherapy
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Introduction: In vitro and animal model studies have shown that Nigella sativa reduces cancer cell proliferation and improves chemotherapy effectiveness. Cellular activation triggers the production of IFN-γ by natural killer (NK) cells. This study examines the effect of Nigella sativa supplementation on IFN-γ levels and quality of life in lung cancer patients before and after interferon therapy.
Methods: This study employed a non-equivalent control experimental design involving 21 lung cancer patients undergoing initial chemotherapy at Dr. Saiful Anwar General Hospital in 2023. The patients were divided into two groups: one group received standard chemotherapy and another group received a combination of chemotherapy and Nigella sativa supplementation at a dose of 2 x 500 mg for nine weeks. The effects of this intervention were assessed by measuring IFN-γ levels using an ELISA kit and evaluating quality of life using the EORTC QLQ-LC13 questionnaire before and after the fourth cycle of chemotherapy.
Results: The results showed a significant increase in IFN-γ levels in the combination group undergoing chemotherapy and receiving Nigella sativa supplementation (6140.44 ± 2233.89) compared to the standard chemotherapy group (3827.08 ± 1722.79), with a p-value of 0.015. Quality of life improved in both groups, with scores of 53.70 ± 6.05 before and 65.74 ± 14.70 after chemotherapy (p = 0.000).
Conclusion: This study found that Nigella sativa supplementation can enhance IFN-γ levels and quality of life in lung cancer patients after four treatment cycles of chemotherapy. These findings indicated that Nigella sativa could be a beneficial supplement for lung cancer patients.
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