Jurnal Rekonstruksi dan Estetik

MECHANISMS AND OUTCOMES OF 1470NM LASER THERAPY FOR VAGINAL REJUVENATION: A MULTI-OMICS OBSERVATIONAL STUDY

Smit Bharat Solanki — 2025-12-01

Highlights:

Multi-omics analysis revealed significant upregulation of genes and proteins linked to collagen remodeling and angiogenesis after 1470nm laser therapy.
The study provides the first integrated clinical and molecular evidence demonstrating the mechanistic role of TGF-β signaling in vaginal tissue regeneration following laser treatment.

Abstract:

Introduction: Vaginal laxity and compromised vascularization significantly impact women’s quality of life, especially post-childbirth and during menopause. Non-invasive therapies, such as 1470nm laser technology, stimulate collagen production and enhance tissue regeneration. This study hypothesizes that 1470nm laser therapy improves vaginal health through collagen remodeling and neovascularization, supported by multi-omics data elucidating key biological pathways.

Methods: This prospective observational study enrolled 120 women aged 25–65 years with symptoms of vaginal laxity, dryness, or decreased elasticity. Participants underwent 3–5 sessions of 1470nm laser therapy. Clinical outcomes were assessed using high-resolution ultrasound, optical coherence tomography (OCT), histopathology, and patient-reported outcomes (FSFI, PGI-I). Multi-omics integration included RNA sequencing, proteomics, and metabolomics.

Results: Vaginal wall thickness increased by 35% (p<0.001), and collagen density improved by 42% (p<0.001). FSFI scores rose by 28% (p<0.001), with 92% of women reporting improved sexual satisfaction. Molecular analyses showed upregulation of collagen synthesis and angiogenesis-related genes (COL1A1, COL3A1, VEGF, FGF), with TGF-β signaling emerging as a key regulatory pathway.

Conclusion: 1470nm laser therapy significantly improves vaginal structure and function with a favorable safety profile. This study uniquely integrates clinical outcomes with multi-omics data, offering novel mechanistic insights and supporting its role in personalized regenerative gynecology.

MICROSURGERY IN A TERTIARY HOSPITAL IN EAST KALIMANTAN: A FIVE-YEAR RETROSPECTIVE STUDY FROM PLASTIC SURGERY DIVISION

Devina Swantara — 2025-12-01

Highlights:

This is the first comprehensive epidemiological analysis of microsurgical cases in East Kalimantan, filling a critical data gap outside Java.
Complex soft-tissue defects accounted for 93.5% of cases, all managed with free flap transfer, predominantly anterolateral thigh and radial forearm flaps.
The observed free flap success rate of 77.5% demonstrates functional microsurgical capacity at a provincial hospital and highlights targets for improving perioperative monitoring and outcomes.

Abstract:

Introduction: Microsurgery is a critical pillar of modern reconstructive surgery, enabling restoration of complex tissue defects. Data on its demography and outcome in East Kalimantan remains unavailable, limiting strategic service planning. This study aimed to describe the perioperative variables and outcome of microsurgical cases at a provincial referral hospital.

Methods: A retrospective study was conducted at the Plastic, Reconstructive, and Aesthetic Surgery Division of Abdoel Wahab Sjahranie Hospital. All patients who underwent microsurgery between January 2020 and December 2024 were included via total sampling. Medical records were reviewed to extract demographic characteristics, referral sources, primary diagnoses, surgical procedures, and free flap outcomes.

Results: A total of 31 surgery in 28 patients, with fluctuating annual distribution (highest in 2020, lowest in 2022). Most patients were male (64.5%) and adults aged 18–60 years (80.7%), predominantly referred from type B hospitals (61.3%). The most frequent diagnosis was complex soft-tissue defects (93.5%), with malignancy, post-burn contracture, chronic wounds, and electrical trauma as leading etiologies. All reconstructions employed free flap transfer with overall success rate was 77.5%, predominance of anterolateral thigh flap (58.1%).

Conclusion: Microsurgical cases at Abdoel Wahab Sjahranie Hospital primarily involved young-to-middle-aged males with complex soft-tissue defects, managed with free flap reconstruction. These findings affirm the hospital’s role as a regional microsurgical referral center and highlight the need for strengthened perioperative monitoring and service expansion beyond trauma-related reconstruction.

THERAPEUTIC POTENTIAL OF SNAIL MUCUS IN WOUND HEALING : A SYSTEMATIC REVIEW AND META-ANALYSIS

Febe Alodia Widjaja — 2025-12-01

Highlights:

Snail mucus extract significantly improves wound healing rates compared to standard treatments.
A meta-analysis of randomized controlled trials (RCTs) showed a statistically significant effect (MD = -3.21%, P < 0.00001).
The bioactive compounds in snail mucus promote collagen production and reduce inflammation.

Abstract

Introduction: Wound healing is a fundamental biological process comprising four sequential and overlapping phases: hemostasis, inflammation, proliferation, and remodeling. The successful restoration of tissue integrity requires that these phases proceed in the correct order and within an appropriate temporal framework. Proteins are indispensable to this process, as they mediate tissue growth, cellular renewal, and reparative mechanisms. Snail mucins, a class of large glycosylated proteins, have been reported to facilitate wound healing by stabilizing protein structures, modulating solubility and viscosity, and enhancing cell–cell recognition. In light of these properties, we conducted a meta-analysis of randomized controlled trials (RCTs) to assess the therapeutic efficacy of snail mucus extract in promoting wound repair.

Method: RCTs on snail mucus extract for wound healing were identified through searches of PubMed, ProQuest, Web of Science, ScienceDirect, Scopus, EBSCOHost, and ClinicalTrials.gov. The review adhered to PRISMA guidelines, applied the PICO framework, and assessed study quality using the JADAD scale.

Result: A total of 60 rats from three RCTs conducted between 2021 and 2023 were included in the meta-analysis. The findings demonstrated that the snail mucus group exhibited a significantly improved wound healing rate compared to the control group (MD = -3.21%, 95% CI: -3.72 to -2.69%, P < 0.00001).

Conclusion: Snail mucus extract has been shown to significantly accelerate wound healing in animal models; however, further clinical studies are required to confirm its therapeutic efficacy in humans.

COMPARATIVE OUTCOMES OF EARLY VERSUS DELAYED WOUND GRAFTING IN BURN PATIENTS: A SYSTEMATIC REVIEW AND META-ANALYSIS

Rafeni Bunga — 2025-12-01

Highlights:

Early wound grafting appears to improve hospital stay duration and functional recovery.
There is a tendency of higher graft success rates and reduced infection risks compared to delayed grafting in burn patients.

Abstract:

Introductions: Burns are a significant global health issue, with over 265 million cases annually. Effective burn wound treatment is crucial, and the timing of surgical skin grafting plays a key role in recovery. Early excision and grafting, typically within 48 hours, is standard practice as it reduces morbidity, mortality, infection, graft failure, and hospitalization. Delaying grafting increases infection risk, while early intervention has been shown to improve wound healing. However, challenges like poor resuscitation and resource limitations may hinder early grafting, particularly in low-resource settings. This review evaluates the evidence on optimal grafting timing in burn patients.

Methods: A systematic review and meta-analysis were conducted. A literature search was conducted from July 2024 to January 2025 comparing early (within 3-7 days) versus delayed (after 7 days) grafting. Studies included randomized controlled trials, cohort studies, and observational studies, with outcomes focused on hospitalization duration, infection rates, blood loss, and limb functionality.

Results: Of 250 studies identified, seven met eligibility criteria. Early grafting significantly reduced hospital stay by 8.89 days (95% CI: -12.88 to -4.89) compared to delayed grafting. No significant differences were observed between early and delayed grafting in terms of blood loss, infection rates, or post-operative grip strength. However, early grafting resulted in better post-operative Total Active Movement (TAM) scores (MD: 22.10 [95% CI: 17.95 to 26.24]).

Conclusion: Early grafting improves hospital recovery and functional outcomes. Further research is needed to confirm these findings.

RECURRENT TEMPOROMANDIBULAR JOINT ANKYLOSIS CAUSED BY OLD FRACTURE: A CASE REPORT

Siti Isya Wahdini — 2025-12-01

Highlights:

Adequate physiotherapy is essential to prevent the recurrence of temporomandibular joint ankylosis.
Surgical treatment alone is insufficient without proper postoperative physiotherapy and patient compliance.

Abstract

Introduction: Temporomandibular joint (TMJ) ankylosis can greatly impact a child's nutrition, mental health, and craniofacial development. Trauma is the main cause. Early and proper treatment is crucial to avoid long-term issues and reoccurrence.

Case Illustration:An 11-year-old girl presented with limited mouth opening and lower jaw pain three years after falling down the stairs. She underwent gradual TMJ distraction using bite blocks under general anesthesia followed by weekly physiotherapy, but her symptoms recurred after four months. A CT scan revealed left TMJ synarthrosis and condylar deformity. With improved adherence to physiotherapy, she achieved significant mouth opening and remained recurrence-free for six months..

Discussion: Gradual distraction with bite blocks, combined with regular physiotherapy, can improve joint mobility and muscle function while lowering the chances of re-ankylosis. This approach offers a less invasive option than surgery, which is especially valuable for children whose growth must be preserved. Closed procedures with structured rehabilitation are preferred because they result in fewer complications and require fewer follow-up appointments.

Conclusion: The effectiveness of a non-invasive approach combining gradual distraction and physiotherapy in managing TMJ ankylosis is presented. The success of this treatment relies heavily on the patient's motivation and commitment. Early conservative treatment could be the main strategy for pediatric cases, potentially delaying or avoiding surgery. Continuous education and monitoring are key to achieving long-term success and preventing relapse.

Jurnal Rekonstruksi dan Estetik, December 2025

JURNAL REKONSTRUKSI DAN ESTETIK — 2025-12-01

Front Matter

WOUND HEALING EFFICACY OF MOIST EXPOSED BURN OINTMENT (MEBO) AND SILVER SULFADIAZINE IN PARTIAL-THICKNESS BURNS: A SYSTEMATIC REVIEW

Aditya Wardhana — 2025-12-01

Highlights:

Superior efficacy between MEBO and SSD in burn patients.
Improved Clinical Outcomes of wound healing in burn patients.
Natural, Plant-Based Alternative for burn patients.

Abstract:

Introduction: Burn injuries are a common global health issue that often require prolonged wound care and can lead to complications such as infections, delayed healing, and surgical interventions. Silver sulfadiazine (SSD) has long been the standard topical treatment for partial-thickness burns, but concerns remain regarding delayed healing and potential side effects. Moist Exposed Burn Ointment (MEBO), a Chinese herbal-based topical agent containing sesame oil, beta-sitosterol, and berberine, has emerged as a potential alternative due to its anti-inflammatory, antimicrobial, and moisture-retaining properties.

Method: This systematic review aimed to evaluate the efficacy of MEBO compared to SSD in partial-thickness burn wound healing. A comprehensive search of PubMed, Cochrane, and Science Direct using the terms “MEBO,” “SSD,” “Burns,” and “Wound healing” identified five trials conducted between 2000 and 2008.

Result: The results consistently demonstrated that MEBO provided comparable or superior outcomes to SSD, including shorter wound healing time, reduced pain, absence of infection in wound swabs, minimal slough and crust formation, lower complication rates, and reduced need for surgical intervention.

Conclusion: These findings suggest that MEBO is an effective and potentially preferable alternative to SSD for managing partial-thickness burn wounds.

EFFECTIVENESS OF ANTIBIOTIC PROPHYLAXIS IN MAXILLOFACIAL TRAUMA SURGERY: A SYSTEMATIC REVIEW

Naufal Agus Isamahendra — 2025-12-01

Highlights:

Antibiotic prophylaxis does not significantly decrease surgical site infection rates in maxillofacial trauma surgery.
Post-operative antibiotic regimens are not recommended as they increase costs without reducing infection rates.

Abstract

Introduction: The effectiveness of antibiotic prophylaxis in maxillofacial trauma surgery remains a subject of debate, with varying recommendations regarding its necessity and duration. This systematic review aims to evaluate the impact of prophylactic antibiotics on the incidence of surgical site infections (SSIs) in maxillofacial trauma patients.

Methods: A systematic literature search was conducted using Google Scholar, following predefined inclusion and exclusion criteria based on the PICO framework. Studies included observational cohort studies comparing the use of prophylactic antibiotics to either no antibiotics or different regimens of antibiotic administration. The quality of the selected studies was assessed using the JBI Critical Appraisal Checklist for Cohort Studies.

Results: Six studies met the inclusion criteria, with five reporting no significant reduction in SSIs with prophylactic antibiotic use, regardless of the timing or duration of administration. Only one study found a statistically significant decrease in SSIs with preoperative antibiotic prophylaxis. Variations in study design, antibiotic regimens, surgical techniques, and patient populations may have influenced the inconsistent findings.

Conclusion: The findings suggest that routine antibiotic prophylaxis in maxillofacial trauma surgery may not be universally beneficial and should be reconsidered in favor of a more selective, patient-specific approach. Given the increasing concerns regarding antimicrobial resistance, prophylactic antibiotics should be reserved for high-risk patients where a clear benefit can be demonstrated. Further research, particularly well-designed randomized controlled trials, is necessary to establish standardized guidelines and optimize perioperative infection control strategies.

Jurnal Rekonstruksi dan Estetik, December 2025

JURNAL REKONSTRUKSI DAN ESTETIK — 2025-12-01

BACK MATTER