THE RELATIONSHIP BETWEEN DURATION OF DIALYSIS AND HISTORY OF BLOOD TRANSFUSION WITH HEPATITIS C SEROPREVALENCE IN HEMODIALYSIS PATIENTS: A CROSS-SECTIONAL STUDY AT GADJAH MADA UNIVERSITY ACADEMIC HOSPITAL

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Background: Hepatitis C Virus (HCV) is an RNA virus that causes hepatitis C disease. Hemodialysis patients are a group at high risk of becoming infected with the HCV. Based on prior research, the duration of hemodialysis has been identified as an independent risk factor for HCV. Risk factors for HCV transmission in hemodialysis patients can also include blood transfusions. Purpose: This research aimed to determine the relationship between the duration of dialysis and the history of blood transfusion with HCV seroprevalence in hemodialysis patients at Gadjah Mada University Academic Hospital. Method: This research utilized a cross-sectional research design. The research data were based on secondary data from the medical records of hemodialysis patients at Gadjah Mada University Academic Hospital. Result: The results were analyzed descriptively and statistically using the Chi-square test with significance (α = 0.05). Data obtained from this research showed that the HCV seroprevalence of hemodialysis patients at Gadjah Mada University Academic Hospital is 20.5%. The test results revealed a relationship between duration of dialysis with HCV seroprevalence in hemodialysis patients is a p-value = 0.021 (p-value < α), and a relationship between history of blood transfusion with HCV seroprevalence in hemodialysis patients is a p-value = 0.024 (p-value < α). Conclusion: The results of the Chi-square test showed a relationship between duration of dialysis and history of blood transfusion with HCV seroprevalence in hemodialysis patients at Gadjah Mada University Academic Hospital.
Adhyatma, G. P., Luthfita, A., Hanjani, A., Nalaresi, A., Nurraga, G. W., Astuti, A. K. Y., Purnomo, H. D., Sofro, M. A. U. 2020. Seroprevalence Hepatitis C Reaktif pada Donor Palang Merah Indonesia Semarang, Jawa Tengah the Seroprevalence of Hepatitis C Reactive in Donors of Indonesian Red Cross Blood Bank Semarang, Central Java. Prosiding Seminar Nasional Unimus.Vol 3. Pp. 651-657.
Aditya, A., Mustofa, F. L., Hidayat, H., Firlanda, Z. R. S. 2022. Prevalensi Hepatitis C pada Donor Darah Sebelum dan pada Saat Pandemi Covid 19 di Unit Transfusi Darah Palang Merah Indonesia Provinsi Lampung Tahun 2019-2020. Malahayati Nursing Journal. Vol 4(6). Pp. 1544–1556.
Alhawaris. 2019. Hepatitis C: Epidemiology, Etiology, and Pathogenicity. Journal of Health Sciences. Vol. 2(2). Pp.139-150.
Bohorquez, M. C., Carnalla, M., Tapia, C.N., Gutiérrez, B.T. 2023. Hepatitis C Mortality Trends in Mexico from 2001 to 2017. Annals of Hepatology. Vol 28(3). Pp. 1-7.
Caragea, D.C., Mihailovoci, A.R., Streba, C.T., Schenker, M., Ungureanu, B., Caragea, I.N., Popa, R., Obleaga,C. Vere, C.C. 2018. Hepatitis C Virus Infection in Hemodialysis Patients. Current Health Sciences Journal. Vol 44 (2). Pp. 107-112.
Chizoba, O. O., Chibuogwu, A. A. 2018. Duration of Dialysis Increases Risk of Hepatitis C Virus Infections among Hemodialysis Patients in Anambra State, Nigeria. Universa Medicina. Vol 37(3). Pp. 173–180.
Dharmesti, N. W. W., Wibawa, I. D. N., Kandarini, Y. 2022. Hepatitis C Seroconversion Remains High among Patients with Regular Hemodialysis: Study of Associated Risk Factors. International Journal of Hepatology. Vol 2022. Pp. 1-8.
Deniz, M.T, Akhan, S. 2023. Hepatitis C Virus Structure and Diagnostic Methods. Intech Open Hepatitis C - Recent Advances. Pp. 1-15.
Jatikusuma, A. 2018. Identification of Positive Anti Hepatitis C Virus and Positive HCV Ribonucleic Acid in The Indonesian Red Cross, Tuban Regency, East Java. Medical Science Journal. Vol 10(2). Pp. 47–50.
Jiang, X., Chang, L., Yan, Y., Ji, H., Sun, H., Guo, F., Wang, L. 2021. A Study Based on Four Immunoassays: Hepatitis C Virus Antibody Against Different Antigens May Have Unequal Contributions to Detection. Virology Journal. Vol 18(1). Pp. 1–10.
Jefferies, M., Rauff, B., Rashid, H., Lam, T., Rafiq, S. 2018. Update on Global Epidemiology of Viral Hepatitis and Preventive Strategies. World Journal of Clinical Cases. Vol 6(13). Pp. 589–599.
Kannan, A., Biswas, L., Kumar, A., Kurian, J., Nair, A. S., Suresh, P., Sadasivan, S., Biswas, R. 2021. Improving Diagnosis of Hepatitis C Virus Infection Using Hepatitis C Core Antigen Testing in A Resource-Poor Setting. Revista Da Sociedade Brasileira de Medicina Tropical. Vol 54. Pp. 1–5.
Kerollos, K.M.N., El-Ameen, H.A., El Wahed, L.A., Azoz, N.M.A. 2020. Prevalence and Seroconversion of Hepatitis C among Hemodialysis Patients in Assiut Governorate, Egypt. The Egyptian Journal of Internal Medicine. Vol 32(1). Pp. 10–15.
Lydia, A., Larasati, A., Gani, RA., Rinaldi, I. 2019. Liver Fibrosis of Hepatitis C Virus Infection in Routine Hemodialysis Patients in Indonesia. Medical Journal of Indonesia. Vol 2. Pp. 375–379.
Martias, V. Y., Ratih, W. U., Kesehatan, P., Setya, B. 2022. Prevalensi Hepatitis C Ada Pendonor Darah di UTD PMI Kabupaten Bantul Tahun 2019-2020. Jurnal Ilmu Kesehatan Bhakti Setya Medika. Vol 7(1). Pp. 57–64.
Ministry of Health. 2019. Pedoman Nasional Pelayanan Kedokteran Tata Laksana Hepatitis C. Keputusan Menteri Kesehatan Republik Indonesia Nomor HK.01.07/MENKES/681/2019
Modin, L., Arshad, A., Wilkes, B., Benselin, J., Lloyd, C., Irving, W. L., Kelly, D. A. 2019. Epidemiology and Natural History of Hepatitis C Virus Infection among Children and Young People. Journal of Hepatology. Vol 70(3). Pp. 371–378.
Morishita, A., Ogawa, C., Moriya, A., Tani, J., Yoneyama, H. 2019. Clinical Outcomes of Hepatitis C Virus Elimination Using Glecaprevir and Pibrantasvir in Hemodialysis Patients: A Multicenter Study. PubMed. Vol 50(5). Pp. 557-564.
Mustika, S., Simatupang, C. D. 2020. Prevalence of Hepatitis B and C Infection among Street Children Community in Malang City. The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy. Vol 21(1). Pp. 12–16.
Niepmann, M., Gerresheim, G. K. 2020. Hepatitis C Virus Translation Regulation. International Journal of Molecular Sciences. Vol 21(7). Pp. 1-33.
Novayanti, D., Loesnihari, R. 2019. Serokonversi Pasien Hemodialisis Reguler di RSUP. H. Adam Malik Medan pada Agustus 2016 – Juli 2017. The Journal of Medical School (JMS). Vol 52(3). Pp. 102–107.
Purwanita, P., Natsir, N. 2021. Studi Diagnostik menggunakan PCR untuk Mendeteksi Virus Hepatitis C dalam Cairan Air Mata Pasien Hemodialisis. Sriwijaya Journal of Medicine. Vol 4(1). Pp. 17–23.
Tang, Q., Chen, Z., Li, H., Zhang, L., Peng, M., Zeng, Y., Liu, X., Liu, Z., Hu, P. 2023. Molecular Epidemiology of Hepatitis C Virus Genotypes in Diferent Geographical Regions of Chinese Mainland and A Phylogenetic Analysis. Infectious Diseases of Poverty. Vol 12(66). Pp. 1-12.
WHO. World Health Organization. 2023. Hepatitis C. Available from:http: www.who.int/news-room/fact-sheets/detail/hepatitis-c (Accessed: 15 September, 2023).
Yerizel, Eti, Almurdi, Revilla, Gusti. 2018. Correlations of Viral Load Toward HCV Core Antigen and Aminotransferase in Hepatitis C Virus Genotype 1 Infection. Journal of Applied Sciences. Vol. 18(2). Pp.103-108.
Zhou, J., Wang, F. Da, Li, L. Q., Chen, E. Q. 2023. Management of In and Out of Hospital Screening for Hepatitis C. Frontiers in Public Health. Vol 10(2). Pp. 1-7.
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