Septum pellucidum CNS malformation malformasi CNS


November 15, 2019


Septum pellucidum is a midline structure between two cerebral hemisphere. It separates the two lateral ventricles. The development of this structure is correlated to brain development. The abnormalities of septum pellucidum, such as agenesis septum pellucidum and cavum septum pellucidum, are usually associated with other CNS anomalies. Agenesis septum pellucidum is relatively rare, estimated to occur in 2-3 per 100.000 births. However, this abnormality is closely associated with the occurrence of grave neuromorbidities i.e. holoprosencephaly, septo-optic dysplasia, malformation of corpus callosum, and chiari malformation type 2,  ventriculomegaly, hippocampal displasia, cerebral cortex displasia, and displasia of optic nerves; whilst abnormality of cavum septum pellucidum is associated to schizophrenia and anti-social personality. The American Institute of Ultrasound in Medicine and American College of Radiology recommends septum pellucidum as one of regular check-up required in the antepartum sonography. It is suggested that the septum pellucidum examination in antenatal care in Indonesia is conducted so that an early treatment plans can be made.

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