Sofia Fajarwati

= http://dx.doi.org/10.20473/mbiom.v27i2.2014.24-29
Abstract views = 47 times | downloads = 5 times


Mesenchymal stem cells(MSCs) are a kind of stem cells that can differentiate into several kinds of mesodermal cell decent. MSCs can be cultured in vitro therefore it can serve many purposes. However, MSCs also have immunosuppresion effects, one of the way is by suppresing T cell proliferation. MSCs need cell-to-cell contact with activated T cells in certain rasio to release it’s surppresion properties. Primery help from inflamatory cytokines is also needed. MSCs’s suppresion effect can be mediated by several molecules such asindoleamine 2,3-dioxygenase (IDO), inducible nitric-oxide synthase (iNOS), prostaglandin E2 (PGE2), transform growth factor-β (TGF-β), hepatocyte growth factor (HGF), and HLA-G5 soluble. MSCs’s characteristic and culture conditions can affect clinical applications.


Mesenchymal stem cells; T cell proliferation; immunosuppresion; proliferasi sel T; imunosupresi

Full Text:



Aggarwal, S. & Pittenger, M.F., 2005. Human mesenchymal stem cells modulate allogeneic immune cell responses. Blood, 105, hal.1815-1822.

Augello, A. et al., 2005. Bone marrow mesen-chymal progenitor cells inhibit lymphocyte proliferation by activation of the programmed death 1 pathway. Eur J Immunol., 35, hal.1482-1490.

Asari, S. et al., 2009. Mesenchymal stem cells suppress B-cell terminal differentiation. Exp Hematol., 37, hal.604–15.

Bassi, E.J. Aita, C.A.M.A. & Câmara, N.O.S., 2011. Immunoregulation and mesenchymal stem cells. World J Stem Cells, 3(1), hal.1-8.

Bianco, P. & Robey, P.G., 2003. Marrow stromal stem cells. J Clin Invest., 105(12), hal.1663-1668.

Birchmeier, C. et al., 2003. Met, metastasis, motility and more. Nat Rev Mol Cell Biol., 4, hal.915–925.

Bottaro, D.P. et al., 1991. Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product. Science, 251, hal.802– 804.

Chabannes, D. et al., 2007. A role for heme oxygenase-1 in the immunosuppressive effect of adult rat and human mesenchymal stem cells. Blood, 110(10), hal.3691-3694.

Chen, L., 2004. Co-inhibitory molecules of the B7-CD28 family in the control of T-cell immunity. Nat Rev Immunol., 4, hal.336-347.

Chen, K. et al., 2010. Human umbilical cord mesenchymal stem cells hUC-MSCs exert immunosuppressive activities through a PGE2-dependent mechanism. Clin Immunol, 135, hal.448-458.

Corcione, A. et al., 2006. Human mesenchymal stem cells modulate B-cell functions. Blood, 107, hal.367-372.

da Silva, M.L. Chagastelles, P.C. & Nardi, N.B., 2006. Mesenchymal stem cells reside in virtually all post-natal organs and tissues. J Cell Sci. 119, hal.2204-2213.

Deans, R.J. & Moseley, A.B., 2000. Mesenchymal stem cells: biology and potential clinical uses. Exp Hematol, 28(8), hal.875-884.

Devadas, S. et al., 2006. Granzyme B is critical for T cell receptor-induced cell death of type 2 helper T cells. Immunity, 25(2), hal.237-247.

di Nicola, M. et al., 2002. Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli. Blood, 99, hal.3838-3843.

Djouad, F. et al., 2003. Immunosuppressive effect of mesenchymal stem cells favors tumor growth in allogeneic animals. Blood, 102, hal.3837-3844.

Dominici, M. et al., 2006. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy, 8, hal.315-317.

Fouillard, L. et al., 2003. Engraftment of allogeneic mesenchymal stem cells in the bone marrow of a patient with severe idiopathic aplastic anemia improves stroma. Leukemia, 17(2), hal.474-476.

Galderisi, U. Jori, F.P. & Giordano, A., 2003. Cell cycle regulation and neural differentiation. Oncogene, 22(33), hal.5208–19.

Gieseke, F., 2007. Human multipotent mesenchymal stromal cells inhibit proliferation of PBMCs independently of IFNγR1 signaling and IDO expression. Blood, 110, hal.2197-2200.

Glennie, S., 2005. Bone marrow mesenchymal stem cells induce division arrest anergy of activated T cells. Blood, 105, hal.2821-2827.

Han, Z.P. et al., 2012. The role of immunosuppression of mesenchymal stem cells in tissue repair and tumor growth. Cell & Bioscience, 2, hal.8.

Jones, B.J. et al., 2007. Immunosuppression by placental indoleamine 2, 3-dioxygenase: a role for mesenchymal stem cells. Placenta, 28(11-12), hal.1174-1181.

Kang, J.W. et al., 2008. Soluble factors-mediated immunomodulatory effects of canine adipose tissue-derived mesenchymal stem cells. Stem Cells Dev., 17, hal.681-693.

Krampera, M. et al., 2003. Bone marrow mesenchymal stem cells inhibit the response of naive and memory antigen-specific T cells to their cognate peptide. Blood, 101, hal.3722-3729.

Krampera, M. et al., 2006. Role for interferon-gamma in the immunomodulatory activity of human bone marrow mesenchymal stem cells. Stem Cells, 24, hal.386-398.

Le Blanc, K. et al., 2004. Mesenchymal stem cells inhibit the expression of CD25 (interleukin-2 receptor) and CD38 on phytohaemagglutinin-activated lymphocytes. Scand J Immunol., 60, hal.307-315.

Lee, O.K. et al., 2004. Isolation of multipotent mesenchymal stem cells from um-bilical cord blood. Blood, 103, hal.1669-1675.

Meisel, R. et al., 2004. Human bone marrow stromal cells inhibit allogeneic T-cell responses by indoleamine 2,3-dioxygenase-mediated tryptophan degradation. Blood, 103, hal.4619-4621.

Najar, M. et al., 2009. Mesenchymal stromal cells promote or suppress the proliferation of T lymphocytes from cord blood and peripheral blood: the importance of low cell ratio and role of interleukin-6. Cytotherapy, 11(5), hal.570-83.

Naldini, L. et al., 1991. Scatter factor and hepatocyte growth factor are indistinguishable ligands for the MET receptor. EMBO J., 10, hal.2867–2878

Nasef, A. et al., 2008. Leukemia inhibitory factor: role in human mesenchymal stem cells mediated immunosuppression. Cell Immunol., 253, hal.16-22.

Nasef, A. et al., 2009. Selected Stro-1-enriched bone marrow stromal cells display a major suppressive eff ect on lymphocyte proliferation. Int J Lab Hematol., 31, hal.9-19.

Nemeth, K. et al., 2009. Bone marrow stromal cells attenuate sepsis via prostaglandin E2-dependent reprogramming of host macrophages to increase their interleukin-10 production. Nat Med., 15, hal.42-49.

Neuss, S. et al., 2004. Functional expression of HGF and HGF receptor/c-met in adult human mesenchymal stem cells suggests a role in cell mobilization, tissue repair and wound healing. Stem Cells, 22, hal.405– 414.

Noel, D. Djouad, F. & Jorgense, C., 2002. Regenerative medicine through mesenchymal stem cells for bone and cartilage repair. Curr Opin Investig Drugs, 3(7), hal.1000-1004.

Opitz, C.A. et al., 2009. Toll-like receptor engagement enhances the immunosuppressive properties of human bone marrow-derived mesenchymal stem cells by inducing indoleamine- 2,3-dioxygenase-1 via interferon-beta and protein kinase R. Stem Cells, 27, hal.909-919.

Pittenger, M.F. et al., 1999. Multilineage potential of adult human mesenchymal stem cells. Science, 284, hal.143-147.

Potian, J.A. et al., 2003. Veto-like activity of mesenchymal stem cells: functional discrimination between cellular responses to alloantigens and recall antigens. J Immunol., 171(7), hal.3426-3434.

Prockop, D.J., 1997. Marrow stromal cells as stem cells for nonhe¬matopoietic tissues. Science, 276, hal.71-74.

Radvanyi, L.G. et al., 1996. Cell cycle progression out of G1 sensitizes primary-cultured nontransformed T cells to TCR-mediated apoptosis. Cell Immunol., 170(2), hal.260-273.

Ramasamy, R. et al., 2008. The immunosuppressive effects of human bone marrow-derived mesenchymal stem cells target T cell proliferation but not its effector function. Cell Immunol., 251, hal.131–6.

Ren, G. et al., 2008. Mesenchymal stem cell-mediated immunosuppression occurs via concerted action of chemokines and nitric oxide. Cell Stem Cell, 2, hal.141-150.

Ren, G. et al., 2009. Species variation in the mechanisms of mesenchymal stem cell-mediated immunosuppression. Stem Cells, 27, hal.1954-1962.

Ryan, J.M. et al., 2007. Interferon-gamma does not break, but promotes the immunosuppressive capacity of adult human mesenchymal stem cells. Clin Exp Immunol., 149, hal.353-363.

Sato, K. et al., 2007. Nitric oxide plays a critical role in suppression of T-cell proliferation by mesenchymal stem cells. Blood, 109, hal.228–34.

Selmani, Z. et al., 2008. Human leukocyte antigen-G5 secretion by human mesenchymal stem cells is required to suppress T lymphocyte and natural killer function and to induce CD4+CD25highFOXP3+ regulatory T cells. Stem Cells, 26, hal.212-222.

Sheng, H.M. et al., 2008. A critical role of IFNγ in priming MSC-mediated suppression of T cell proliferation through up-regulation of B7-H1. Cell Research, 18, hal.846-857.

Spaggiari, G.M. et al., 2009. MSCs inhibit monocytederived DC maturation and function by selectively interfering with the generation of immature DCs: central role of MSC-derived prostaglandin E2. Blood, 113, hal.6576-6583.

Trusolino, L. & Comoglio, P.M., 2002. Scatter-factor and semaphorin receptors: cell signalling for invasive growth. Nat Rev Cancer, 2, hal.289 –300.

Tse, W.T. et al., 2003. Suppression of allogeneic T-cell proliferation by human marrow stromal cells: implications in transplantation. Transplantation, 75, hal.389-397.

Woodbury, D. et al., 2000. Adult rat and human bone marrow stromal cells differentiate into neurons. J Neurosci Re., 61, hal.364-370.

Yanez, R. et al., 2010. Prostaglandin E2 plays a key role in the immunosuppressive properties of adipose and bone marrow tissue-derived mesenchymal stromal cells. Exp Cell Res., 316, hal.3109–23.

Zhang, W. et al., 2004. Effects of mesenchymal stem cells on differentiation, maturation, and function of human monocyte-derived den-dritic cells. Stem Cells Dev., 13, hal.263-271.


  • There are currently no refbacks.

Copyright (c) 2019 Majalah Biomorfologi

Creative Commons License
Majalah Biomorfologi (p-ISSN:0215-8833; e-ISSN:2716-0920) is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

View Majalah Biomorfologi Statistics


 Indexed By