HAMBATAN MESENCHYMAL STEM CELL TERHADAP PROLIFERASI LIMFOSIT T

Sofia Fajarwati

= http://dx.doi.org/10.20473/mbiom.v27i2.2014.24-29
Abstract views = 47 times | downloads = 5 times

Abstract


Mesenchymal stem cells(MSCs) are a kind of stem cells that can differentiate into several kinds of mesodermal cell decent. MSCs can be cultured in vitro therefore it can serve many purposes. However, MSCs also have immunosuppresion effects, one of the way is by suppresing T cell proliferation. MSCs need cell-to-cell contact with activated T cells in certain rasio to release it’s surppresion properties. Primery help from inflamatory cytokines is also needed. MSCs’s suppresion effect can be mediated by several molecules such asindoleamine 2,3-dioxygenase (IDO), inducible nitric-oxide synthase (iNOS), prostaglandin E2 (PGE2), transform growth factor-β (TGF-β), hepatocyte growth factor (HGF), and HLA-G5 soluble. MSCs’s characteristic and culture conditions can affect clinical applications.


Keywords


Mesenchymal stem cells; T cell proliferation; immunosuppresion; proliferasi sel T; imunosupresi

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References


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