STRUKTUR DAN PERAN SITOSKELETON PADA ERITROSIT

Rimbun Rimbun

= http://dx.doi.org/10.20473/mbiom.v28i2.2015.38-45
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Abstract


The cytoskeleton is a structural molecule that plays a role in the maintenance of cell shape and preserve cell structure that allowing the movement of organelles, chromosomes, cilia, and the movement of the cell itself. Cytoskeleton in erythrocyte becomes interesting to discuss because it plays an important role in maintaining cell shape and flexibility of great strength in resisting friction with the walls of capillaries that has smaller diameter than erythrocytes. The aim was to discuss structure and function of cytoskeleton, especially in erythrocyte membrane. The cytoskeleton of erythrocyte membrane is mainly composed by spectrin, a long chain-shaped protein, thin, and flexible. Spectrin is supported by a wide range of peripheral and integral proteins, such as ankyrin, actin, a protein band 4.1, and 4.2, the protein band 3 (anion transporter proteins), as well as glycophorin A, B, C, to form a framework in order to support the shape and flexibility of erythrocytes. Abnormalities of spectrin can cause hereditary spherocytosis and hereditary elliptocytosis, which has manifestations as hemolytic anemia.


Keywords


cytoskeleton; red blood cell; cell membrane; sitoskeleton; sel darah merah; membran sel

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References


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