Original Research

The prognostic role of mitosis index, stage and grade of endometrial cancer in Dr. Soetomo General Academic Hospital Surabaya, Indonesia, in 2018-2020

Farida Umi Choviva1, Willy Sandhika2,3, Pungky Mulawardhana4
1Midwifery Program, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia, 2Department/ Medical staff of Anatomic Pathology, Faculty of Medicine, Universitas Airlangga/ Dr. Soetomo General Academic Hospital, Surabaya, Indonesia, 3International Association of Pathologist, Indonesia Division, 4Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Airlangga/ Dr. Soetomo General Academic Hospital, Surabaya, Indonesia.

HIGHLIGHTS

1. Mitotic index and grade are prognostic factors for endometrial cancer, but both are independent.
2. Stage and mitotic index associated with cell proliferation affect the prognosis of endometrial cancer.

ABSTRACT


Objectives: To analyze the correlation between the mitotic index and stage and grade of endometrial cancer.
Materials and Methods: Endometrial cancer pathology reports were collected from the Pathology laboratory Dr Soetomo General Hospital Surabaya during 2018 – 2020. The number of cases obtained was 106 cases of endometrial cancer. In each case, the stage, grade, and mitotic index were recorded, and a Spearman rank statistical analysis was carried out to determine the correlation between these variables.
Results: There is a correlation between the mitotic index and the cancer stage. This shows that an increase in the proliferation index of cancer cells will increase the cancer stage. There is no correlation between the mitotic index and the grade of endometrial cancer, which indicates that the grade of endometrial cancer is unrelated to the grade of cancer cell proliferation.
Conclusion: Mitotic index correlates with the stage of endometrial cancer and does not correlate with the grade of cancer cells.

Keywords: Reproductive health; endometrial cancer; molecular prognostic factors; maternal health