Systematic Review

The use of N-acetylcysteine to prevent further progression of preeclampsia

I Wayan Agung Indrawan, Leny Silviana Farida
Department of Obstetric and Gynecologic, Faculty of Medicine, University of Brawijaya, Malang, Indonesia

HIGHLIGHTS

1. The generation of free radicals in the placenta leads to endothelial dysfunction, which contributes greatly in preeclampsia.
2. N-acetylcysteine have a role in the oxidative stress pathway, helping in glutathione synthesis and as a free radical scavenger.
3. N-Acetylcysteine supplementation in women with preexisting preeclampsia had positive effects on oxidative stress biomarkers, laboratory values, and blood pressure.

ABSTRACT

Objectives: Preeclampsia is a very common disorder which the pathophysiology of preeclampsia remains in academic debate. N-acetylcysteine (NAC) have a role in the oxidative stress pathway, helping in glutathione synthesis and as a free radical scavenger. This study aims to examine the role of NAC on women with preeclampsia.
Materials and Methods: Using the Pubmed and ScienceDirect database, 17 and 395 articles were obtained. Reviews were then excluded from both pooled articles, resulting in 12 articles from Pubmed and 89 articles from ScienceDirect.
Results: A total of 5 articles were included in this review, consisting of 2 human studies and 3 animal studies. A reduction in preeclampsia rate using NAC in women having increased risk of preeclampsia.
Conclusion: NAC supplementation in women with preexisting preeclampsia had positive effects on oxidative stress biomarkers, laboratory values, and blood pressure. No significant difference was found in the rate of maternal complications

Keywords: N-acetylcysteine; preeclampsia, antioxidant; endothelial dysfunction; glutathione synthesis; maternal health