25(OH)D Inadequacy Has Different Pathway with VEGF in Increases the Risk of Severe Preeclampsia

Hanifa Erlin Damayanti, Aditiawarman Aditiawarman

= http://dx.doi.org/10.20473/mog.V23I22015.42-48
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Abstract


Objectives: To identify in vivo correlation between 25(OH)D and VEGF in severe preeclampsia.

Materials and Methods: A case control, cross sectional study of 36 pregnant women which consist of 18 patients with preeclampsia and 18 patients as control with gestational age-matched. We perform 25(OH)D serum examination by chemiluminescent immunoassay (CLIA) and VEGF serum examination by sandwich ELISA to all patients.

Results: All patients are in 25(OH)D insufficiency and deficiency state. Both maternal 25(OH)D and VEGF levels were inversely associated with the risk of preeclampsia (both P<0.05). There is no correlation between 25(OH)D serum level and VEGF serum level (P=0,629).

Conclusion: Maternal vitamin D deficiency is associated with increased preeclampsia risk. However, our data do not support the hypothesis that the association between vitamin D deficiency and preeclampsia is mediated by impaired level of VEGF.


Keywords


25-hydroxyvitamin D, vascular endothelial growth factor, preeclampsia

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References


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