25(OH)D Inadequacy Has Different Pathway with VEGF in Increases the Risk of Severe Preeclampsia

Hanifa Erlin Damayanti, Aditiawarman Aditiawarman

= http://dx.doi.org/10.20473/mog.V23I22015.42-48
Abstract views = 503 times | downloads = 628 times


Objectives: To identify in vivo correlation between 25(OH)D and VEGF in severe preeclampsia.

Materials and Methods: A case control, cross sectional study of 36 pregnant women which consist of 18 patients with preeclampsia and 18 patients as control with gestational age-matched. We perform 25(OH)D serum examination by chemiluminescent immunoassay (CLIA) and VEGF serum examination by sandwich ELISA to all patients.

Results: All patients are in 25(OH)D insufficiency and deficiency state. Both maternal 25(OH)D and VEGF levels were inversely associated with the risk of preeclampsia (both P<0.05). There is no correlation between 25(OH)D serum level and VEGF serum level (P=0,629).

Conclusion: Maternal vitamin D deficiency is associated with increased preeclampsia risk. However, our data do not support the hypothesis that the association between vitamin D deficiency and preeclampsia is mediated by impaired level of VEGF.


25-hydroxyvitamin D, vascular endothelial growth factor, preeclampsia

Full Text:



Green TJ, Skeaff CM, Rockell JE, et al. Vitamin D status and its association with parathyroid hormone concentrations in women of child-bearing age living in Jakarta and Kuala Lumpur. European journal of clinical nutrition. 2008;62(3):373-8.

Garland CF, Garland FC, Gorham ED, et al. The role of vitamin D in cancer prevention. American journal of public health. 2006;96(2):252-61.

Holick MF. The Vitamin D Defi ciency Pandemic: a Forgotten Hormone Important for Health. Public Health Reviews. 2012;32:267-83.

Dror DK, Allen LH. Vitamin D inadequacy in pregnancy: biology, outcomes, and interventions. Nutrition reviews. 2010;68(8):465-77.

Hollis BW, Wagner CL. Vitamin D deficiency during pregnancy: an ongoing epidemic. Am J Clin Nutr. 2006;84:273.

Bodnar LM, Catov JM, Simhan HN, Holick MF, Powers RW, Roberts JM. Maternal vitamin D deficiency increases the risk of preeclampsia. The Journal of clinical endocrinology and metabolism. 2007;92(9):3517-22.

Hypponen E, Turner S, Cumberland P, Power C, Gibb I. Serum 25-hydroxyvitamin D measurement in a large population survey with statistical harmonization of assay variation to an international standard. The Journal of clinicalendocrinology and metabolism. 2007;92(12):4615-22.

Lechtermann C, Hauffa BP, Herrmann R, et al. Maternal vitamin D status in preeclampsia: seasonal changes are not influenced by placental gene expression of vitamin D metabolizing enzymes. Plos One. 2014;9(8):105558.

Arunabh S, Pollack S, Yeh J, Aloia JF. Body fat content and 25-hydroxyvitamin D levels in healthy women. The Journal of clinical endocrinology and metabolism. 2003;88(1):157-61.

De-Regil LM, Palacios C, Ansary A, Kulier R, Peña-Rosas JP. Vitamin D supplementation for women during pregnancy (Review). Cochrane Database of Systematic Reviews. 2012(2).

Tsiaras WG, Weinstock MA. Factors influencing vitamin D status. Acta dermato-venereologica. 2011;91(2):115-24.

Mulligan ML, Felton SK, Riek AE, Bernal-Mizrachi C. Implications of vitamin D deficiency in pregnancy and lactation. Am J Obstet Gynecol. 2010;202(5):1-9.

Sachan A, Gupta R, Das V, Agarwal A, Awasthi PK, Bhatia V. High prevalence of vitamin D deficiency among pregnant women and their newborns in northern India. The American Journal of Clinical Nutrition. 2005:1060-4.

Urrutia RP, Thorp JM. The Vitamin D Deficiency Pandemic: a Forgotten Hormone Important for Health. Public Health Reviews. 2010;32:267-83.

Haugen M, Brantsaeter A, Trogstad L, et al. Vitamin D supplementation and reduced risk of preeclampsia in nulliparous women. Epidemiology. 2009;20.

Wang A, Rana S, Karumanchi SA. Preeclampsia: The Role of Angiogenic Factors in Its Pathogenesis. Physiology. 2009;24:147-58.

Thorne-Lyman A, Fawzi WW. Vitamin D during pregnancy and maternal, neonatal and infant health outcomes: a systematic review and meta-analysis. Paediatric and perinatal epidemiology. 2012;26(1):75-90.

Wei S-Q, Qi H-P, Luo Z-C, Fraser W. Maternal vitamin D status and risk of preeclampia: a systematic review and meta-analysis. American Journal of Obstetrics & Gynecology. 2013:305.

Wei S, Bilodeau JF, Julien P, et al. Association of maternal vitamin D status and oxidative stress during pregnancy and risk of preeclampsia. American Journal of Obstetrics and Gynecology. 2014;210(1):169-70.


  • There are currently no refbacks.

Copyright (c) 2016 Majalah Obstetri & Ginekologi



Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License