Clinical manifestations comparison in hospitalized pregnant and non-pregnant women with Covid-19 at Mataram University Hospital, Mataram, Indonesia
Downloads
HIGHLIGHTS
1. Clinical manifestations in pregnant and non-pregnant women with Covid-19 were identified.
2. Pregnant women with Covid-19 mostly had asymptomatic clinical manifestations, while non-pregnant women with Covid-19 mostly had symptomatic clinical manifestations.
3. Recognition of the clinical manifestations in pregnant women with Covid-19 may help early detection and treatment of pregnant Covid-19 patients.
ABSTRACT
Objectives: To know a comparison of clinical manifestations in pregnant and non-pregnant Covid-19 patients who are hospitalized at Mataram University Hospital.
Materials and Methods: This study was a descriptive observational study with a cross-sectional approach, using secondary data in the form of medical records. This study uses a total sampling technique, sample selection based on affordable population, inclusion criteria, and exclusion criteria. The data was processed with SPSS 25th version and analyzed with a Chi-square analysis test.
Results: In this study, it was found that 145 women confirmed Covid-19 on RT-PCR, 89 of which were pregnant and 56 others weren't; 85.4% of the included pregnant women were in the 3rd trimester. Clinical manifestations in pregnant women are 73.0% asymptomatic while symptomatic in 60.7% of the non-pregnant women. In symptomatic pregnant women, most common clinical symptoms were nausea, vomiting, cough, and headache; while the most common clinical symptoms in non-pregnant women were cough, anosmia, and headache. Chi-square analysis test showed a significant relationship with p = 0.000 (p < 0.05) in clinical manifestation comparison.
Conclusion: There are differences in clinical manifestations in pregnant and non-pregnant women with Covid-19. The most common clinical manifestation in pregnant women was asymptomatic and in non-pregnant women the most common clinical manifestation was symptomatic.
World Health Organization (WHO). Transmisi SARS-CoV-2: Implikasi terhadap kewaspadaan pencegahan infeksi [SARS-CoV-2. Implication of infection prevention efforts]. WHO Guideline 2020. [internet] [Cited 2021 Jan 4]. Available from: https://www.who.int/docs/default-source/searo/ indonesia/covid19/transmisi-sars-cov-2---implikasi-untuk-terhadap-kewaspadaan-pencegahan-infeksi---pernyataan-keilmuan.pdf?sfvrsn=1534d7df_4
Gao YJ, Ye L, Zhang JS, et al. Clinical features and outcomes of pregnant women with COVID-19: a systematic review and meta-analysis. BMC Infect Dis. 2020;20(1):564. doi: 10.1186/s12879-020-05274-2. PMID: 32746801; PMCID: PMC739 6931.
Rohmah MK, Nurdianto AR. Corona Virus Disease 2019 (Covid-19) pada wanita hamil dan bayi: Sebuah tinjauan literatur. Medica Hospital Journal of Clinical Medicine. 2020;7(1): 329-36. doi: 10.36408/mhjcm.v7i1A.476.
Handayani RT, Setyorini C, Darmayanti AT, et al. Infeksi Covid-19 pada kehamilan dan persalinan. Jurnal Informasi Kesehatan Indonesia. 2020;6(1): 1-5. doi: 10.31290/jiki.v6i1.1503.
Allotey J, Stallings E, Bonet M, et al.; for PregCOV-19 Living Systematic Review Consort-ium. Clinical manifestations, risk factors, and maternal and perinatal outcomes of coronavirus disease 2019 in pregnancy: living systematic review and meta-analysis. BMJ. 2020;370:m3320. doi: 10.1136/bmj.m3320. Update in: BMJ. 2022 May 30;377:o1205. PMID: 32873575; PMCID: PMC7459193.
Ji HL, Zhao R, Matalon S, et al. Elevated plasmin(ogen) as a common risk factor for COVID-19 susceptibility. Physiol Rev. 2020;100(3):1065-75. doi: 10.1152/physrev.00013.2020. Epub 2020 Mar 27. PMID: 32216698; PMCID: PMC7191627.
Wiyati PS, Adawiyah R, Dewantiningrum J, Pramono BA. Maternal and perinatal outcomes with Covid-19: Lesson learned from the tertiary hospital. Bali Medical Journal. 2021;10(1):442-7. doi: 10.15562/bmj.v10i1.2229
Delahoy MJ, Whitaker M, O'Halloran A, et al. ; COVID-NET Surveillance Team. Characteristics and maternal and birth outcomes of hospitalized pregnant women with laboratory-confirmed COVID-19 - COVID-NET, 13 States, March 1-August 22, 2020. MMWR Morb Mortal Wkly Rep. 2020;69(38):1347-54. doi: 10.15585/mmwr. mm6938e1. PMID: 32970655; PMCID: PMC7727 497.
Wu X, Sun R, Chen J, et al. Radiological findings and clinical characteristics of pregnant women with COVID-19 pneumonia. Int J Gynaecol Obstet. 2020;150(1):58-63. doi: 10.1002/ijgo.13165. Epub 2020 Jun 3. Erratum in: Int J Gynaecol Obstet. 2021 Mar;152(3):465. PMID: 32270479; PMCID: PMC9087759.
Berhan Y. What immunological and hormonal protective factors lower the risk of COVID-19 related deaths in pregnant women? J Reprod Immunol. 2020;142:103180. doi: 10.1016/j.jri. 2020.103180. Epub 2020 Jul 18. PMID: 32739645; PMCID: PMC7368414.
Pinna G. Sex and COVID-19: A protective role for reproductive steroids. Trends Endocrinol Metab. 2021;32(1):3-6. doi: 10.1016/j.tem.2020.11.004. Epub 2020 Nov 9. PMID: 33229187; PMCID: PMC7649655.
Breslin N, Baptiste C, Gyamfi-Bannerman C, et al. Coronavirus disease 2019 infection among asymptomatic and symptomatic pregnant women: two weeks of confirmed presentations to an affiliated pair of New York City hospitals. Am J Obstet Gynecol MFM. 2020;2(2):100118. doi: 10.1016/j.ajogmf.2020.100118. Epub 2020 Apr 9. PMID: 32292903; PMCID: PMC7144599.
Afshar Y, Gaw SL, Flaherman VJ, et al. ; Pregnancy CoRonavIrus Outcomes RegIsTrY (PRIORITY) Study. Clinical Presentation of Coronavirus Disease 2019 (COVID-19) in Pregnant and Recently Pregnant People. Obstet Gynecol. 2020;136(6):1117-25. doi: 10.1097/AOG.00000000 00004178. PMID: 33027186; PMCID: PMC767 3633.
Yuki K, Fujiogi M, Koutsogiannaki S. COVID-19 pathophysiology: A review. Clin Immunol. 2020; 215:108427. doi: 10.1016/j.clim.2020.108427. Epub 2020 Apr 20. PMID: 32325252; PMCID: PMC7169933.
Cevik M, Kuppalli K, Kindrachuk J, et al. Virology, transmission, and pathogenesis of SARS-CoV-2. BMJ. 2020;371:m3862. doi: 10.1136/bmj. m3862. PMID: 33097561.
Ikawaty R. Dinamika interaksi reseptor ACE2 dan SARS-CoV-2 terhadap manifestasi klinis Covid-19. Jurnal Kesehatan dan Kedokteran. 2020;1(2):70-6. doi:10.24123/kesdok.V1i2.2869.
Beyerstedt S, Casaro EB, Rangel í‰B. COVID-19: angiotensin-converting enzyme 2 (ACE2) expression and tissue susceptibility to SARS-CoV-2 infection. Eur J Clin Microbiol Infect Dis. 2021;40(5):905-19. doi: 10.1007/s10096-020-04138-6. Epub 2021 Jan 3. PMID: 33389262; PMCID: PMC7778857.
Ejaz H, Alsrhani A, Zafar A, et al. COVID-19 and comorbidities: Deleterious impact on infected patients. J Infect Public Health. 2020;13(12):1833-9. doi: 10.1016/j.jiph.2020.07.014. Epub 2020 Aug 4. PMID: 32788073; PMCID: PMC7402107.
Scialo F, Daniele A, Amato F, et al. ACE2: The major cell entry receptor for SARS-CoV-2. Lung. 2020;198(6):867-77. doi: 10.1007/s00408-020-00408-4. Epub 2020 Nov 10. PMID: 33170317; PMCID: PMC7653219.
Wang B, Kovalchuk A, Li D, et al. In search of preventive strategies: novel high-CBD Cannabis sativa extracts modulate ACE2 expression in COVID-19 gateway tissues. Aging (Albany NY). 2020;12(22):22425-44. doi: 10.18632/aging. 202225. Epub 2020 Nov 22. PMID: 33221759; PMCID: PMC7746344.
Copyright (c) 2022 Majalah Obstetri & Ginekologi
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
1. Copyright of the article is transferred to the journal, by the knowledge of the author, whilst the moral right of the publication belongs to the author.
2. The legal formal aspect of journal publication accessibility refers to Creative Commons Attribution-Non Commercial-Share alike (CC BY-NC-SA), (https://creativecommons.org/licenses/by-nc-sa/4.0/)
3. The articles published in the journal are open access and can be used for non-commercial purposes. Other than the aims mentioned above, the editorial board is not responsible for copyright violation
The manuscript authentic and copyright statement submission can be downloaded ON THIS FORM.