The role of adequate vitamin D levels in the menstrual cycle of reproductive-age women
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HIGHLIGHTS
1. This study reviews the effect of adequate levels of serum vitamin D on menstrual cycle
2. Vitamin D affects the length and regularity of menstrual cycle
3. Women with vitamin D insufficiency typically report irregular and prolonged menstrual periods than women with adequate vitamin D levels.
ABSTRACT
Objective: This study investigated the role of adequate vitamin D levels in the menstrual cycle of reproductive-age women.
Materials and Methods: We systematically searched using certain key words in PubMed and ScienceDirect for English articles, full articles, published between August 2013 - August 2022 that evaluated the effect of vitamin D levels on the menstrual cycle of women in reproductive age. The results were analyzed qualitatively.
Results: Eight studies from 653 recorded articles were eligible for review. Decreased vitamin D levels can cause menstrual cycle irregularities, which are related to a decrease in the hormone estradiol, affecting the menstrual cycle. In addition, lower levels of vitamin D lead to longer menstrual cycles.
Conclusion: Vitamin D is vital in the menstrual cycle because it influences the frequency and duration of menstruation.
Draper CF, Duisters K, Weger B, et al. Menstrual cycle rhythmicity: metabolic patterns in healthy women. Sci Rep 2018;8(1):1–15.
Park YJ, Shin H, Jeon S, et al. Menstrual cycle patterns and the prevalence of premenstrual syndrome and Polycystic Ovary Syndrome in Korean young adult women. Healthcare (Basel). 2021;9(1):56. doi: 10.3390/healthcare9010056. PMID: 33430265; PMCID: PMC7825721.
Bull JR, Rowland SP, Scherwitzl EB, et al. Real-world menstrual cycle characteristics of more than 600,000 menstrual cycles. NPJ Digit Med. 2019; 2:83. doi: 10.1038/s41746-019-0152-7. PMID: 31482137; PMCID: PMC6710244.
Singh M, Rajoura OP, Honnakamble RA. Menstrual patterns and problems in association with body mass index among adolescent school girls. J Family Med Prim Care. 2019;8(9):2855-8. doi: 10.4103/jfmpc.jfmpc_474_19. PMID: 31681 655; PMCID: PMC6820408.
Wang YX, Arvizu M, Rich-Edwards JW, et al. Menstrual cycle regularity and length across the reproductive lifespan and risk of premature mortality: prospective cohort study. BMJ. 2020;371 :m3464. doi: 10.1136/bmj.m3464. PMID: 32998 909; PMCID: PMC7526082.
Dimitrov V, Barbier C, Ismailova A, et al Vitamin D-regulated Gene Expression Profiles: Species-specificity and Cell-specific Effects on Metabolism and Immunity. Endocrinology. 2021;162(2) :bqaa218. doi: 10.1210/endocr/bqaa218. PMID: 33249469; PMCID: PMC7751191.
Saponaro F, Saba A, Zucchi R. An update on vitamin D metabolism. Int J Mol Sci. 2020;21(18) :6573. doi: 10.3390/ijms21186573. PMID: 32911 795; PMCID: PMC7554947.
Lerchbaum E, Rabe T. Vitamin D and female fertility. Curr Opin Obstet Gynecol. 2014;26(3) :145-50. doi: 10.1097/GCO.0000000000000065. PMID: 24717915.
Arslan S, Akdevelioğlu Y. The relationship between female reproductive functions and vitamin D. J Am Coll Nutr. 2018;37(6):546-51. doi: 10.1080/07315724.2018.1431160. Epub 2018 Mar 13. PMID: 29533153.
Jukic AM, Steiner AZ, Baird DD. Lower plasma 25-hydroxyvitamin D is associated with irregular menstrual cycles in a cross-sectional study. Reprod Biol Endocrinol. 2015;13:20. doi: 10.1186/s12958-015-0012-5. PMID: 25879830; PMCID: PMC 4359493.
Paffoni A, Ferrari S, Viganò P, et al. Vitamin D deficiency and infertility: insights from in vitro fertilization cycles. J Clin Endocrinol Metab. 2014 ;99(11):E2372-6. doi: 10.1210/jc.2014-1802. Epub 2014 Aug 14. PMID: 25121462.
Pagliardini L, Vigano' P, Molgora M, et al. High prevalence of vitamin D deficiency in infertile women referring for assisted reproduction. nutrients. 2015;7(12):9972-84. doi: 10.3390/ nu7125516. PMID: 26633484; PMCID: PMC 4690068.
Bikle D, Christakos S. New aspects of vitamin D metabolism and action - addressing the skin as source and target. Nat Rev Endocrinol. 2020 ;16(4):234-52. doi: 10.1038/s41574-019-0312-5. Epub 2020 Feb 6. PMID: 32029884.
Bahrami A, Avan A, Sadeghnia HR, et al. High dose vitamin D supplementation can improve menstrual problems, dysmenorrhea, and pre-menstrual syndrome in adolescents. Gynecol Endocrinol. 2018;34(8):659-63. doi: 10.1080/ 09513590.2017.1423466. Epub 2018 Feb 15. PMID: 29447494.
Drakopoulos P, van de Vijver A, Schutyser V, et al. The effect of serum vitamin D levels on ovarian reserve markers: a prospective cross-sectional study. Hum Reprod. 2017;32(1):208-14. doi: 10.1093/humrep/dew304. Epub 2016 Dec 6. PMID: 27927849.
Harris HR, Chavarro JE, Malspeis S, et al. Dairy-food, calcium, magnesium, and vitamin D intake and endometriosis: a prospective cohort study. Am J Epidemiol. 2013;177(5):420-30. doi: 10.1093/aje/ kws247. Epub 2013 Feb 3. PMID: 23380045; PMCID: PMC3626048.
Jukic AMZ, Upson K, Harmon QE, et al. Increasing serum 25-hydroxyvitamin D is associated with reduced odds of long menstrual cycles in a cross-sectional study of African American women. Fertil Steril. 2016;106(1):172-9.e2. doi: 10.1016/j.fertnstert.2016.03.004. Epub 2016 Mar 18. PMID: 26997249; PMCID: PMC 4930882.
Drakopoulos P, van de Vijver A, Schutyser V, et al. The effect of serum vitamin D levels on ovarian reserve markers: a prospective cross-sectional study. Hum Reprod. 2017;32(1):208-14. doi: 10.1093/humrep/dew304. Epub 2016 Dec 6. PMID: 27927849.
Alkhalaf Z, Kim K, Kuhr DL, et al. Markers of vitamin D metabolism and premenstrual symptoms in healthy women with regular cycles. Hum Reprod. 2021;36(7):1808-20. doi: 10.1093/humrep/ deab089. PMID: 33864070; PMCID: PMC 853 0167.
Harmon QE, Kissell K, Jukic AMZ, et al. Vitamin D and reproductive hormones across the menstrual cycle. Hum Reprod. 2020;35(2):413-23. doi: 10.1093/humrep/dez283. PMID: 32068843; PM CID: PMC7986370.
Page MJ, McKenzie JE, Bossuyt PM, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021;372:n71. doi: 10.1136/bmj.n71. PMID: 33782057; PMCID: PMC8005924.
Moola S, Munn Z, Tufanaru C, et al. JBI manual for evidence synthesis [Internet]. JBI, 2020. Available from: https://synthesismanual.jbi.global
Tufanaru C, Munn Z, Aromataris E, et al. JBI manual for evidence synthesis [Internet]. JBI, 2020. Available from: https://synthesismanual.jbi.global
Jukic AMZ, Wilcox AJ, McConnaughey DR, et al. 25-hydroxyvitamin D and long menstrual cycles in a prospective cohort study. Epidemiology. 2018 ;29(3):388-96. doi: 10.1097/EDE.0000000000 000804. PMID: 29337846; PMCID: PMC5882585.
Al-Bayyari N, Al-Domi H, Zayed F, et al. Androgens and hirsutism score of overweight women with polycystic ovary syndrome improved after vitamin D treatment: A randomized placebo controlled clinical trial. Clin Nutr. 2021;40(3):870-8. doi: 10.1016/j.clnu.2020.09.024. Epub 2020 Sep 24. PMID: 33010974.
Jafari-Sfidvajani S, Ahangari R, Hozoori M, et al. The effect of vitamin D supplementation in combination with low-calorie diet on anthropo-metric indices and androgen hormones in women with polycystic ovary syndrome: a double-blind, randomized, placebo-controlled trial. J Endocrinol Invest. 2018;41(5):597-607. doi: 10.1007/s40618-017-0785-9. Epub 2017 Nov 6. PMID: 29110281.
Åagowska K. The relationship between vitamin D status and the menstrual cycle in young women: A preliminary study. Nutrients. 2018;10(11):1729. doi: 10.3390/nu10111729. PMID: 30423869; PM CID: PMC6265788.
Singh V, Tamar N, Lone Z, et al. Association between serum 25-hydroxy vitamin D level and menstrual cycle length and regularity: A cross-sectional observational study. Int J Reprod Biomed. 2021;19(11):979-86. doi: 10.18502/ijrm.v19i11. 9913. PMID: 34977455; PMCID: PMC8717082.
Tartagni M, Cicinelli MV, Tartagni MV, et al. Vitamin D supplementation for premenstrual syndrome-related mood disorders in adolescents with severe hypovitaminosis D. J Pediatr Adolesc Gynecol. 2016;29(4):357-61. doi: 10.1016/j.jpag. 2015.12.006. Epub 2015 Dec 24. PMID: 26724745.
Franasiak JM, Wang X, Molinaro TA, et al Free vitamin D does not vary through the follicular phase of the menstrual cycle. Endocrine. 2016 ;53(1):322-6. doi: 10.1007/s12020-016-0946-1. Epub 2016 Apr 6. PMID: 27052515.
Tehrani HG, Mostajeran F, Shahsavari S. The effect of calcium and vitamin D supplementation on menstrual cycle, body mass index and hyper-androgenism state of women with poly cystic ovarian syndrome. J Res Med Sci. 2014;19(9):875-80. PMID: 25535503; PMCID: PMC4268197.
Kadoura S, Alhalabi M, Nattouf AH. Effect of calcium and vitamin D supplements as an adjuvant therapy to metformin on menstrual cycle abnormal-ities, hormonal profile, and IGF-1 system in Polycystic Ovary Syndrome patients: A random-ized, placebo-controlled clinical trial. Adv Pharmacol Sci. 2019;2019:9680390. doi: 10.1155/ 2019/9680390. PMID: 31354810; PMCID: PMC 6636596.
Jenkinson C. The vitamin D metabolome: An update on analysis and function. Cell Biochem Funct. 2019;37(6):408-23. doi: 10.1002/cbf.3421. Epub 2019 Jul 22. PMID: 31328813.
Wieder-Huszla S, Jurczak A, Szkup M, et al. Relationships between vitamin D₃ and metabolic syndrome. Int J Environ Res Public Health. 2019 ;16(2):175. doi: 10.3390/ijerph16020175. PMID: 30634516; PMCID: PMC6352038.
Muscogiuri G, Altieri B, de Angelis C, et al. Shedding new light on female fertility: The role of vitamin D. Rev Endocr Metab Disord. 2017;18(3) :273-83. doi: 10.1007/s11154-017-9407-2. PMID: 28102491.
Subramanian A, Gernand AD. Vitamin D meta-bolites across the menstrual cycle: a systematic review. BMC Womens Health. 2019;19(1):19. doi: 10.1186/s12905-019-0721-6. PMID: 30691458; PMCID: PMC6348668.
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