Testosterone and sexual function in menopausal women based on the Female Sexual Function Index (FSFI) score
Downloads
HIGHLIGHTS
- Testosterone level correlates with FSFI score, showing that sexual function correlates with hormonal physiology.
- FSFI is a valid and useful tool in measuring sexual function.
ABSTRACT
Objective: This research aimed to analyze the correlation between testosterone levels and sexual function in postmenopausal women.
Materials and Methods: This research was a descriptive observational study with a case series approach conducted at Aras Kabu Health Center Outpatient Polyclinic from May to August 2022. The normality test was carried out using the Shapiro-Wilk test. If the data were not normally distributed, data would be analyzed using the Spearman correlation test. If the data were normally distributed, the data analysis would use the Pearson correlation test.
Results: There was a significant relationship between Female Sexual Function Index (FSFI) score with testosterone levels and duration of menopause with p<0.05. The degree of correlation found was 0.619 between testosterone levels and FSFI scores, indicating a moderate and significant positive correlation. A correlation degree of 0.482 was found between FSFI and length of menopause which indicated a significant moderate positive correlation, while the degree of correlation between testosterone levels and length of menopause was found to be 0.711, showing a strong and significant positive correlation.
Conclusion: There is a significant relationship between FSFI scores with testosterone levels and duration of menopause as well. There was also a significant relationship between testosterone levels and the duration of menopause.
Siregar MFG, Azmeila S, Sitompul AN, et al. Literature review: menopause and sexual disorders. Maced J Med Sci. 2021; 9(3):298-304. doi: 10. 3889/oamjms.2021.6345.
Pajalic Z, Raboteg-Å aric Z. Determinant of menopause-related symptoms in women during the transition to menopause and postmenopausal period - a systematic literature review. JHSCI. 2020;10 (1):1-33. doi: 10.17532/jhsci.2020.885.
Siregar MFG. Optimizing the quality of life of postmenopausal women in Indonesia. Medan: 2017.
Siregar MFG. Perimenopausal and postmenopausal complaints in paramedics assesed by Menopause Rating Scale in Indonesia. IOSR J Dent Med Sci. 2014;13:38–42.
Dunsmoor-Su R, Fuller A, Voedisch A. Testos-terone therapy in women: A clinical challenge. Obstet Gynecol. 2021;138(5):809-12. doi: 10.1097 /AOG.0000000000004566. PMID: 34619691.
Heidari M, Ghodusi M, Rezaei Heidari M, Ghodusi M, Rezaei P, et al. Sexual function and factors affecting menopause: A systematic review. J Menopausal Med. 2019;25(1):15-27. doi: 10.6118/ jmm.2019.25.1.15. Epub 2019 Apr 25. PMID: 31080785; PMCID: PMC6487288.
Hayes RD, Dennerstein L, Bennett CM, et al. Relationship between hypoactive sexual desire disorder and aging. Fertil Steril. 2007;87(1):107-12. doi: 10.1016/j.fertnstert.2006.05.071. Epub 2006 Nov 1. PMID: 17081522.
Achilli C, Pundir J, Ramanathan P, et al. Efficacy and safety of transdermal testosterone in post-menopausal women with hypoactive sexual desire disorder: a systematic review and meta-analysis. Fertil Steril. 2017;107(2):475-482.e15. doi: 10.1016/j.fertnstert.2016.10.028. Epub 2016 Dec 1. PMID: 27916205.
Yang L, Lin L, Kartsonaki C, et al.; China Kadoorie Biobank Study Collaborative Group. Menopause characteristics, total reproductive years, and risk of cardiovascular disease among chinese women. Circ Cardiovasc Qual Outcomes. 2017;10 (11):e004235. doi: 10.1161/CIRCOUTCOMES. 117.004235. PMID: 29117982; PMCID: PMC570 4734.
Ahuja M. Age of menopause and determinants of menopause age: A PAN India survey by IMS. J Midlife Health. 2016;7(3):126-31. doi: 10.4103/ 0976-7800.191012. PMID: 27721640; PMCID: PMC5051232.
Ismail SA, Abdel-Azim NE, Saleh MA, et al. A new grading system for female sexual dysfunction based on the female sexual function index in Egyptian women: a cross-sectional study. Afr Health Sci. 2021;21(2):835-41. doi: 10.4314/ahs. v21i2.44. PMID: 34795742; PMCID: PMC 8568215.
Hurrahmi M, Mardiyan KE, Denas AA, et al. Profile of sexual function using Female Sexual Function Index (FSFI) in post-menopausal women in Geriatric Clinic, Dr Soetomo Hospital, Surabaya. Majalah Obstetri & Ginekologi. 2018;25(2):54–8. doi: 10.20473/mog.V25I22017.54-58.
Jones ME, Schoemaker M, Rae M, et al. Changes in estradiol and testosterone levels in post-menopausal women after changes in body mass index. J Clin Endocrinol Metab. 2013;98(7):2967-74. doi: 10.1210/jc.2013-1588. Epub 2013 May 10. PMID: 23666973.
Randolph JF Jr, Sowers M, Gold EB, et al. Reproductive hormones in the early menopausal transition: relationship to ethnicity, body size, and menopausal status. J Clin Endocrinol Metab. 2003;88(4):1516-22. doi: 10.1210/jc.2002-020777. PMID: 12679432.
Johansen N, Lindén Hirschberg A, Moen MH. The role of testosterone in menopausal hormone treatment. What is the evidence? Acta Obstet Gynecol Scand. 2020;99(8):966-69. doi: 10.1111/ aogs.13819. Epub 2020 Mar 2. PMID: 32027015.
Traeen B, Stigum H. Sexual problems in 18-67-year-old Norwegians. Scand J Public Health. 2010;38(5):445-56. doi: 10.1177/140349481037 1245. Epub 2010 May 21. PMID: 20494944.
Pérez-Herrezuelo I, Aibar-Almazán A, Martínez-Amat A, et al. Female sexual function and its association with the severity of menopause-related symptoms. Int J Environ Res Public Health. 2020; 17(19):7235. doi: 10.3390/ijerph17197235. PMID: 33022931; PMCID: PMC7579461.
Cappelletti M, Wallen K. Increasing women's sexual desire: The comparative effectiveness of estrogens and androgens. Horm Behav. 2016;78:178-93. doi: 10.1016/j.yhbeh.2015.11.003. Epub 2015 Nov 14. PMID: 26589379; PMCID: PMC4720522.
Dennerstein L, Koochaki P, Barton I, et al. Hypoactive sexual desire disorder in menopausal women: a survey of Western European women. J Sex Med. 2006;3(2):212-22. doi: 10.1111/j.1743-6109.2006.00215.x. PMID: 16490014.
Tungmunsakulchai R, Chaikittisilpa S, Snabboon T, et al. Effectiveness of a low dose testosterone undecanoate to improve sexual function in post-menopausal women. BMC Womens Health. 2015;15:113. doi: 10.1186/s12905-015-0270-6. PM ID: 26631095; PMCID: PMC4668626.
Pangastuti N, Santoso BI, Agustiningsih D, et al. Validation test of Indonesian female sexual function index (Indonesian FSFI). Bali Medical Journal. 2019;8(1):164-8. doi: 10.15562/bmj.v8i1. 1138.
Nazarpour S, Simbar M, Tehrani FR. Factors affecting sexual function in menopause: A review article. Taiwan J Obstet Gynecol. 2016;55(4):480-7. doi: 10.1016/j.tjog.2016.06.001. PMID: 2759 0367.
Nathorst-Böös J, Flöter A, Jarkander-Rolff M, et al. Treatment with percutanous testosterone gel in postmenopausal women with decreased libido--effects on sexuality and psychological general well-being. Maturitas. 2006;53(1):11-8. doi: 10.1016/j. maturitas.2005.01.002. Epub 2005 Sep 23. PMID: 16183220.
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
1. Copyright of the article is transferred to the journal, by the knowledge of the author, whilst the moral right of the publication belongs to the author.
2. The legal formal aspect of journal publication accessibility refers to Creative Commons Attribution-Non Commercial-Share alike (CC BY-NC-SA), (https://creativecommons.org/licenses/by-nc-sa/4.0/)
3. The articles published in the journal are open access and can be used for non-commercial purposes. Other than the aims mentioned above, the editorial board is not responsible for copyright violation
The manuscript authentic and copyright statement submission can be downloaded ON THIS FORM.
