Effect of prenatal Mozart composition on Brain Derived Neurotrophic Factor expression in cerebrum and cerebellum of Rattus norvegicus offspring from Food Restriction 50 model
Downloads
Objectives: To analyze the difference of BDNF expression on Rattus norvegicus offspring FR50 model in cerebrum and cerebellum between Mozart composition stimulation group and control.
Materials and Methods: An analytical experimental study with single blind randomized post test only control group using animal subjects Rattus norvegicus FR50 model. This study was conducted at animal laboratory, Faculty of Veterinary Medicine, Airlangga University. Animal subjects were divided into Mozart music stimulation group and control. The BDNF expression was analyzed using comparison test, with significancy p<0,05.
Results: There was no difference of BDNF expression on Rattus norvegicus offspring FR50 model between Mozart music stimu-lation group and control in cerebrum with p=0.495 (mean Mozart group 6.89+2.52 vs control 6.22+1.99), and cerebellum with p=0.146 (mean Mozart group 7.41+2.67 vs control 5.73+2.45).
Conclusions: There was no difference of BDNF expression between Mozart composition stimulation group and control in the cerebrum and cerebellum of Rattus norvegicus offspring FR50 model.Johnson MH. 2003. Development of Human Brain Functions. Biol Psychiatry. 54:1312–1316.
Hermanto TJ, Estoepangesti ATS, Widjiati. 2002. The Influence of Musical Exposure to Pregnant (Rattus norvegicus) Rat to the Amount of Neonatal Rat Brain Cells. Abstract of the 3rd Scientific Meeting on Fetomaternal Medicine and AOFOG Accredited Ultrasound Workshop. 2002: 31.
Hermanto TJ. 2004. Smart Babies through Prenatal University Mission Impossible? Majalah Obstetri dan Ginekologi Indonesia, 28(1):14.
Alamy M, Bengelloun WA. 2012. Malnutrition and Brain Development: An Analysis of the Effects of Inadequate Diet During Different Stages of Life in Rat. Neuroscience and Biobehavioral Reviews. 36:1463–1480.
Hermanto TJ. 2012. Bersujud dalam Rahim 2, Mencerdaskan Janin Sejak Dalam Rahim Dengan Kombinasi Stimulasi 11 – 14 Musik Mozart dan Nutrisi. Global Persada Press.
Suryanti NW, Angsar D, Hermanto TJ, Maramis M. 2009. Perbandingan Kadar Brain Derived Neurotrophic Factor (BDNF) Serum Darah Tali Pusat Bayi Baru Lahir antara Ibu Hamil yang Mendapat dengan tidak Mendapat Paparan Musik Mozart selama Hamil. Laporan Penelitian. SMF Kebidanan dan Penyakit Kandungan FK Unair/RSU dr Soetomo Surabaya. Tidak dipublikasikan.
Widyanto T, Hermanto TJ. 2013. Perbandingan Kadar Brain Derived Neurotrophic Factor (BDNF) Serum Darah Tali Pusat Bayi Baru Lahir antara Ibu Hamil yang Mendapat DHA dengan Kombinasi DHA dan 11-14 Karya Mozart Selama Hamil. Majalah Obstetri dan Ginekologi Indonesia, 21:109-114.
Rauscher FH, Shaw, GL, Ky KN. 1993. Music and spatial task performance. Nature, 365(6447), 611.
Kim H, Lee MH, Chang HK, Lee TH. 2006. Influence of Prenatal Noise and Music on the Spatial Memory and Neurogenesis in the Hippocampus of Developing Rats. Brain Dev.28(2):109-14.
Marzban M, Shahbazi A, Tondar M, Soleimani M, Bakhshayesh M, Moshkforoush A, et al. 2011. Effect of Mozart Music on Hippocampal Content of BDNF in Postnatal Rats. BCN. 2 (3): 21-26.
Aryananda RA, Hermanto TJ, Widjiati. 2016. Pengaruh Paparan Musik Mozart Selama Kebuntingan terhadap ekspresi Brain Derived Neurotrophic Factor (BDNF), Jumlah Sel Glia dan Sel Neuron. Studi Eksperimental pada Cerebrum dan Cerebellum Anak Rattus norvegicus Baru Lahir. Laporan Penelitian SMF Obstetri dan Ginekologi FK Unair/RSUD dr Soetomo Surabaya. Tidak dipublilkasikan.
Vieau D, Mayeur S, Lukaszewski M, Delahave F, Dutriez-Castleloot I, Laborie C, et al. 2011. Perinatal Undernutrition and Brain Derived Neurotrophic Factor in Handbook of Behavior and Nutrition. Volume 1-Parts 1-5. London: Springer. P: 2055-2067.
Volpe JJ. 2001. Neurology of The Newborn (4 ed). Philladelphia, USA: WB Sauders. P: 45-99.
Stiles J, Jernigan TL. 2010. The Basics of Brain Development. Neuropsycol Rev, 327-348.
Barker DJ. 2006. Adult Consequences of fetal Growth Restriction. Clin Obstet Gynecol. 49:270–83.
Coupé B, Dutriez-Casteloot I, Breton C, Lefèvre F, Mairesse J, Dickes-Coopman A, et al. 2009. Perinatal Undernutrition Modifies Cell Proliferation and Brain Derived Neurotrophic Factor Levels During Critical Time-Windows for Hypothalamic and Hippocampal Development in the Male Rat. J Neuroendocrinol. 21:40–8.
Hogan B, Constantini F, Lacy E. 1986. Summary of Mouse Development in Manipulating the Mouse Embryo A Laboratory Manual. Cold Spring Harbor Laboratory. P: 18-77.
Ernawati, Hermanto TJ, Widjiati. 2008. Perbandingan Indeks Apoptosis Sel Otak Anak Tikus (Rattus Novergicius) Baru Lahir Antara yang Mendapat Paparan Lagu Mozart Sejak Awal Kebuntingan, Setelah Kebuntingan 10 Hari dan yang Tidak Mendapat Paparan. Laporan Penelitian. SMF Obstetri dan Ginekologi FK Unair/RSUD dr Soetomo Surabaya. Tidak dipublikasikan.
Chaudhury S, Wadhwa S. 2009. Prenatal auditory stimulation alters the levels of CREB mRNA, p-CREB and BDNF expression in chick hippocampus. Int. J. Dev. Neurosci. 27 583–90.
Chaudhury S, Jain S, Wadhwa S. 2010. Expression of synaptic proteins in the hippocampus and spatial learning in chicks following prenatal auditory stimulation. Dev. Neurosci. 32.
Chaudhury S, Nag TC, Jain S, Wadhwa S. 2013. Review : Role of Sound Stimulation in Reprogramming Brain Connectivity. J. Biosci. 38(3), 605–614.
Kusuma IP, Hermanto TJ, Sulistyono A. 2005. Perbandingan Perubahan Profil Biofisik Janin Akibat Paparan Lagu Mozart K265 pada Siang dan Malam Hari. Laporan Penelitian. SMF Obstetri dan Ginekologi FK Unair/RSUD dr Soetomo Surabaya. Tidak dipublikasikan.
Petacchi A, Laird AR, Fox PT, Bower JM. 2005. Cerebellum and Auditory Function: An ALE Meta-Analysis of Functional Neuroimaging Studies. Human Brain Mapping 25:118 –128.
Carter AR, Chen C, Schwartz PM, Segal RA. 2002. Brain-Derived Neurotrophic Factor Modulates Cerebellar Plasticity and Synaptic Ultrastructure. The Journal of Neuroscience, 22(4):1316–1327.
Chikahisa S, Sei H, Morishima M, Sano A, Kitaoka K, Nakaya Y, et al. 2006. Exposure to Music in the Perinatal Period Enhances Learning Performance and Alters BDNF/TrkB Signaling in Mice as Adults. Behav Brain Res. 169, 312–319.
Wang L, Xu R. 2007. The Effects of Perinatal Protein Malnutrition on Spatial Learning and Memory Behaviour and Brain-Derived Neurotrophic Factor Concentration in the Brain Tissue in Young Rats. Asia Pac J Clin Nutr. 16: 467-472.
Roy S, Sable P, Khaire A, Randhir K, Kale A, Joshi S. 2013. Effect of maternal micronutrients (folic acid and vitamin B12) and omega 3 fatty acids on indices of brain oxidative stress in the offspring. Brain Dev (2013).http://dx.doi.org/10.1016/j.braindev.2013.03.004.
Sable P, Kale A, Joshi A, Joshi S. 2014. Maternal micronutrient imbalance alters gene expression of BDNF, NGF, TrkB and CREB in the offspring brain at an adult age. Int. J. Devl Neuroscience. 34 (2014) 24–32.
Kundakovic M, Jaric I. 2017. The Epigenetic Link between Prenatal Adverse Environments and Neurodevelopmental Disorders. Genes 2017, 8, 104; doi:10.3390/genes8030104, www.mdpi.com/journal/genes.
1. Copyright of the article is transferred to the journal, by the knowledge of the author, whilst the moral right of the publication belongs to the author.
2. The legal formal aspect of journal publication accessibility refers to Creative Commons Attribution-Non Commercial-Share alike (CC BY-NC-SA), (https://creativecommons.org/licenses/by-nc-sa/4.0/)
3. The articles published in the journal are open access and can be used for non-commercial purposes. Other than the aims mentioned above, the editorial board is not responsible for copyright violation
The manuscript authentic and copyright statement submission can be downloaded ON THIS FORM.
