Risk of meningioma associated with exposure of hormonal contraception. A case control study
Downloads
Objective: To determine the effect of hormonal contraceptive exposure on the development of meningioma.
Materials and Methods: This case–control study, conducted in 2016, included all patients diagnosed histopathologically with meningioma between 2012 and 2013 and treated at Dr. Soetomo General Hospital, Surabaya, Indonesia. Medical record data from these patients were collected and compared with a control group consisting of non-meningioma patients who underwent contrast-enhanced head CT scans and direct interviews. A total of 101 cases and 101 controls were analyzed. Data were evaluated using univariate logistic regression analysis.
Results: Patients with a history of hormonal contraceptive use had a 12.31-fold higher risk of developing meningioma (p = 0.000). In this study, women using monthly injectable contraceptives or oral contraceptive pills demonstrated a lower risk of meningioma compared to those using three-month injectable contraceptives. Participants who had used hormonal contraception for more than 10 years had an 18.216-fold increased risk of developing meningioma (p = 0.000). Histopathological analysis revealed no significant association between hormonal contraceptive history and meningioma subtype distribution; however, descriptive data indicated that the transitional type was the most frequent histopathological subtype among the case group.
Conclusion: There is a significant association between hormonal contraceptive use and the occurrence of meningioma, particularly with the use of three-month injectable hormonal contraception and long-term use exceeding 10 years. No significant association was observed between meningioma histopathological grade and a history of hormonal contraceptive exposure.
Anic GM, Madden MH, Nabors LB, Olson JJ, LaRoccA RV, Thompson ZJ, Pamnani SJ, Forsyth PA, Thompson RC, Egan KM. 2014. Reproductive factors and risk of primary brain tumor in women. J Neurooncol, 118: 297 – 304.
Andew P Morokoff, Jacob Zauberman, Peter.M Black. (2008). Jurnal of Neurosurgery 63; 427-434.
Al Mefty Ossama. Meningiomas. Raven Press. First Ed. New York 1991
Brian T.Ragel and Randy L Jensen ( 2005 ). Molecular genetic of meningioma. Neurosurg Focus 19 (5).
Central Brain Tumor Registry of United States 2004-2006 CBTRUS. (2010, February). Retrieved from http://www.cbtrus.org/2010-NPCR-SEER/CBTRUS-WEBREPORT-Final-3-2-10.pdf
Choy, W., Kim, W., Nagasawa, D., Stramotas, S., Yew, A., Gopen, Q., Parsa, AT., Yang I. (2011). The Molecular Genetics and Tumor Pathogenesis of Meningiomas and Future Directions of Meningioma Treatment. Neurosurg Focus, 30(5):E6.
Claus, EB., Calvocoressi, L., Bondy, ML., Wrensch, M., Wiemels, JL., Schildkraut, JM. (2013). Exogenous hormon use, reproductive factors, and risk of intracranial meningioma in females. J Neurosurg, 118(3):649-656.
Custer, B., Longstreth, WT Jr., Phillips, LE., Koepsell, TD., Van Belle, G. (2006). Hormonal exposures and the risk of intracranial meningioma in women : a population-based case-control study, BMC Cancer, 7;6:152.
DeMonte, F., McDermott, MW., Al-Mefty, O. (2011). Al-Mefty's Meningiomas, 2nd ed, Thieme Medical Publishers, New York.
Fan ZX, Shen J, Wu YY, Yu H, Zhan RY. 2013. Hormone replacement therapy and risk of meningioma in women: a meta analysis. Cancer Causes Control, 24: 1517 – 1525.
Kaunitz AM. Long-acting Injectable contraception with depot medoxyprogesterone acetate. Am J Obstet Gynecol 1994; 170:1543
Pamir M.N, Black Peter, Fahlbush RF, Meningiomas a Comprehensive Text.Saunders Elsevier 2010.
Westphal, M, et al., 2006, Neuro-Oncology of CNS Tumors, Springer, Berlin Heidelberg, New York.
Wiemels, J, Wrensch M, Claus EB. (2010). Epidemiology and Etiology of Meningioma. J Neurooncol, 99(3):307-14.
Wigertz, A., Lönn, S., Mathiesen, T., Ahlbom, A., Hall, P., Feychting, M., Swedish Interphone Study Group. (2006). Risk of Brain Tumors Associated with Exposure to Exogenous Female sex Hormones, Am J. Epidemiol, 164(7):629-36
Ramamurthi dan Tandon's. Manual of Neurosurgery. First edition Jaypee Brother's medical publishers (P) LTD. New Delhi. 2014
Sastroasmoro S, Ismael S. (2011). Dasar-dasar Metodologi Penelitian Klinis, Edisi ke-4, Sagung Seto, Jakarta.
Vadivelu, S., Schulder, M., Hayat, MA. (2012). Tumors of the Central Nervous System Volume 7 Meningioma and Schwannoma.. Springer. New York. P 29-36
Copyright (c) 2018 Majalah Obstetri & Ginekologi
This work is licensed under a Creative Commons Attribution 4.0 International License.
1. Copyright of the article is transferred to the journal, by the knowledge of the author, whilst the moral right of the publication belongs to the author.
2. The legal formal aspect of journal publication accessibility refers to Creative Commons Attribution-Non Commercial-Share alike (CC BY-NC-SA), (https://creativecommons.org/licenses/by-nc-sa/4.0/)
3. The articles published in the journal are open access and can be used for non-commercial purposes. Other than the aims mentioned above, the editorial board is not responsible for copyright violation
The manuscript authentic and copyright statement submission can be downloaded ON THIS FORM.
