THE PREVALENCE OF HUMAN IMMUNODEFIENCY VIRUS-1 (HIV-1) SUBTYPES AND TRANSMISSION METHOD AMONG HIV/AIDS INFECTION PATIENT IN TULUNGAGUNG, EAST JAVA INDONESIA

Achmad Ardianto; Siti Qamariyah Khairunisa; Tomohiro Kotaki; Adiana Mutamsari Witaningrum; M. Qushay; Juniastuti Juniastuti; Retno Pudji Rahayu; Prihartini Widiyanti; Budi Utomo; Maria Inge Lusida; Nasronudin Nasronudin

doi:10.20473/ijtid.v5i5.305

THE PREVALENCE OF HUMAN IMMUNODEFIENCY VIRUS-1 (HIV-1) SUBTYPES AND TRANSMISSION METHOD AMONG HIV/AIDS INFECTION PATIENT IN TULUNGAGUNG, EAST JAVA INDONESIA

Achmad Ardianto, Siti Qamariyah Khairunisa, Tomohiro Kotaki, Adiana Mutamsari Witaningrum, M. Qushay, Juniastuti Juniastuti, Retno Pudji Rahayu, Prihartini Widiyanti, Budi Utomo, Maria Inge Lusida, Nasronudin Nasronudin

= http://dx.doi.org/10.20473/ijtid.v5i5.305

Abstract views = 1689 times |

downloads = 649 times

Abstract

The rapid epidemic growth of HIV is continuing in Indonesia. There are some factors which have influenced the spreading of this epidemic in Indonesia, such as the poor awareness to avoid unsafe free sex attitude and the sharing of needles and syringes among intravenous drug users (IDUs). The sexual transmission of HIV has also apparently increased in Tulungagung. Commercial sex workers play a significant role in the spread of HIV in Tulungagung. People in Tulungagung have worked at other countries as Indonesian migrants. This condition can cause the increase number of HIV-1 case and the possibility of genetic variation (subtype) HIV-1 in Tulungagung. This research is aimed to analyze the subtype and to determine estimation of transmission mode on infected patient of HIV-1 and AIDS who came to Seruni clinic Dr. Iskak hospital in Tulungagung. 40 HIV?AIDSpatients were interviewed to determine the subtype and the transmission mode. The results showed that 14 of 40 plasma samples (35%) were successfully to amplified and sequenced. OverallCRF01-AE wereidentified as predominant subtype among HIV/AIDS patients in Tulungagung. Based on individual information, 31 of 40 subjects (77%) were heterosexual transmission.

Keywords

prevalence; subtype; transmission mode; HIV-1; Tulungagung

Full Text:

PDF

References

Kementrian Kesehatan Republik Indonesia:Estimasi dan Proyeksi HIV/AIDS di Indonesia: Tahun 2011–2016. 2014.

Ruxrungtham K, Brown T, Praphan P.: HIV/AIDS in Asia. 2004; www.thelancet.com; Vol. 364: July 3.

Nicholas I Paton: HIV in South East Asia. 2005; Medicine Publishing Company. 33: 6.

Handajani R, Nasronudin, Lusida MI, Lindawati, Effendi F, Utsumi T, 2010. ‘Analisis molekuler phylogenetic human immunodeficiency virus (HIV) pada pasien di Surabaya, Jawa Timur’. Majalah Kedokteran Indonesia, vol. 60, pp. 172–176.

Dinkes Tulungagung, 2008. Penanggulangan HIV/AIDS. http://dinkestulungagung.blogspot.com/2008/01/penanggulangan-hivaids. html, diakses pada tanggal 27Agustus 2014 jam 09.31.

Dinkes Tulungagung, 2013. Data kumulatif HIV-AIDS oktober 2013. http://dinkes.tulungagung.go.id/, diakses tanggal 18 Mei 2014, jam 07.30.

Tamura K, Peterson D, Peterson N, et al.: MEGA5: Molecular Evolutionary Genetics Analysis Using Maximum Likelihood, Evolutionary Distance, and Maximum Parsimony Methods. Mol. Biol. Evol 2011; 28:2731–2739.

Kimura M: A Simple Method for Estimating Evolutionary Rates of Base Substitutions Through Comparative Studies of Nucleotide Sequences. J Mol Evol 1980; 16: 111–120.

Requejo H IZ: Worldwide molecular epidemiology of HIV. Rev Saúde Pública 2006; 40: 331–45.

Auwanit W, Isarangkura-Na-Ayuthaya P, Kasornpikul D, et al.: Detection of Drug Resistance-Associated and Background Mutations in Human Immunodeficiency Virus Type 1 CRF01_AE Protease and Reverse Transcriptase Derived from Drug Treatment-Naive Patients Residing in Central Thailand. AIDS Research and Human Retroviruses 2009; 25: 625–631.

Mohamada S, Derisa ZZ, Yusoffb NK, et al.: Assessing subtypes and drug resistance mutations among HIV-1 infected children who failed antiretroviral therapy in Kelantan, Malaysia. The Brazilian Journal of Infectious Diseases 2012; 16: 284–288.

Stone V, Ojikutu B, Rawlings MK, Smith KY, 2009. HIV/AIDS in U.S. communities of color. Springer Science & Business Media, Boston, pp. 86.

Ajayi JO, 2003. The HIV-AIDS epidemic in Nigeria: some ethical considerations. Gregorian Biblical BookShop, Roma, pp. 24.

Shuvra KD, Nazneen Z, Sabrina A. Molecular epidemiology of HIV in Asia. Polish AIDS Research Society: 2014: 1730–1270.

Sahbandar IN, TakahashiK, DjoerbanZ, FirmansyahI, NaganawaS, MotomuraK, SatoH, KitamuraK, PohanHT, SatoS, 2009. ‘Current HIV type 1 molecular epidemiology profile and identification of unique recombinant forms in Jakarta, Indonesia’. U.S. national Llibrary of medicine, 8600 Rockville Pike, Bethesda MD, 20894 USA.

Kotaki T, Khairunisa SQ, Sukartiningrum SD, Arfijanto MV, Utsumi T, Normalina I, Handajani R, Widiyanti P, Rusli M, Rahayu RP, Lusida MI, Hayashi Y, Nasronudin, Kameoka M, 2013. ‘High prevalence of HIV-1 CRF01_AE viruses among female commercial sex workers residing in Surabaya, Indonesia’. Plos one, vol. 8 (12) pp. 1–8.