Organ Damage due to Elevation of Blood Pressure on NaCl-induced
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Introduction: High salt diet is known to induce or aggravate hypertension in hypertensive rats and humans. The elevation of blood pressure by NaCl-induced promotes cardiac hypertrophy, the impairment of left ventricular relaxation, endothelial dysfunction, and kidney injury. This study aimed to examine whether NaCl-induced caused increase blood pressure and weight of organs.
Methods: Eight weeks old male Mus musculus were divided to two groups, one group was given NaCl 8% by intraperitoneal injection for 8 hours.
Results: Blood pressure was measured previously, in this study systolic and diastolic blood pressure increased significantly (p < 0.05). The increasing of blood pressure was followed by significant increase in organ weight, such as heart and kidney (p < 0.05).
Conclusion: This result suggested that NaCl-induced caused hypertension and increased organs weight that may cause early process of damages in organs.
Kaplan NM. Kaplan’s clinical hypertension. Lippincott Williams & Wilkins, 2010.
De Miguel C, Das S, Lund H and Mattson DL. T lymphocytes mediate hypertension and kidney damage in Dahl salt-sensitive rats. American journal of physiology Regulatory, integrative and comparative physiology. 2010; 298: R1136-42.
Kotchen TA, Cowley AW, Jr. and Frohlich ED. Salt in health and disease--a delicate balance. The New England journal of medicine. 2013; 368: 1229-37.
Cook NR, Cutler JA, Obarzanek E, et al. Long term effects of dietary sodium reduction on cardiovascular disease outcomes: observational follow-up of the trials of hypertension prevention (TOHP). Bmj. 2007; 334: 885-8.
Hall JE. Renal Dysfunction, Rather Than Nonrenal Vascular Dysfunction, Mediates Salt-Induced Hypertension. Circulation. 2016; 133: 894-906.
McCallum L, Jeemon P, Hastie CE, et al. Serum Chloride Is an Independent Predictor of Mortality in Hypertensive Patients. Hypertension. 2013; 62: 836-43.
Schmidlin O, Tanaka M, Sebastian A and Morris RC, Jr. Selective chloride loading is pressor in the stroke-prone spontaneously hypertensive rat despite hydrochlorothiazide-induced natriuresis. Journal of hypertension. 2010; 28: 87-94.
Whelton PK, Carey RM, Aronow WS, et al. 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Hypertension. 2018; 71: e13-e115.
Sanada H, Jones JE and Jose PA. Genetics of salt-sensitive hypertension. Current hypertension reports. 2011; 13: 55-66.
Mattson DL, James L, Berdan EA and Meister CJ. Immune Suppression Attenuates Hypertension and Renal Disease in the Dahl Salt-Sensitive Rat. Hypertension. 2006; 48: 149-56.
Walkowska A, Kuczeriszka M, Sadowski J, et al. High salt intake increases blood pressure in normal rats: putative role of 20-HETE and no evidence on changes in renal vascular reactivity. Kidney & blood pressure research. 2015; 40: 323-34.
Crowley SD, Gurley SB, Herrera MJ, et al. Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney. Proceedings of the National Academy of Sciences of the United States of America. 2006; 103: 17985-90.
Rossier BC, Staub O and Hummler E. Genetic dissection of sodium and potassium transport along the aldosterone-sensitive distal nephron: importance in the control of blood pressure and hypertension. FEBS letters. 2013; 587: 1929-41.
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