Analgesic Effect of Dayak Onion (Eleutherine americana (Aubl.) Merr.) on Mice (Mus musculus) by Hot Plate Test Method
Downloads
Methods: The research was conducted experimentally on 36 BALB/c male mice which randomly divided into 6 different treatment groups of Dayak onion exctract, aspirin, codein and aquadest. Each group were thermally pain-induced for latency period measurement by the hot plate test method. Obtained data were processed using Analysis of Variance (ANOVA) followed by Dunnett test.
Results: There was a difference in the latency period between the baseline response time and the response time after being treated in each group. ANOVA test results showed significant results (p<0.05) so that the resulting latency period was significant. Dunnett test results showed significant results (p<0.05) in negative control group. Based on these results, Dayak onion are proven to have an analgesic effect on heat stimulation.
Conclusion: Dayak onion possess significant analgesic effect on thermally pain-induced mice. Dayak onion extract 90 mg/kg mouse produced better analgesic effects than aspirin 65 mg/kg mouse.
Raja SN, Carr DB, Cohen M, Finnerup NB, Flor H, Gibson S, et al. The revised International Association for the Study of Pain definition of pain: concepts, challenges, and compromises. Pain. 2020;161(9):1976–1982.
Hall J, Hall M. Guyton and Hall Textbook of Medical Physiology. 14th ed. Philadelphia; Elsevier; 2020.
Katzung B, Kruidering-Hall M, Trevor A. Katzung & Trevor's Pharmacology.11th ed. New York; McGraw-Hill Education; 2015.
Henschke N, Kamper SJ, Maher CG. The epidemiology and economic consequences of pain. Mayo Clinic Proceedings. 2015;90(1):139–147.
Duthey B, Scholten W. Adequacy of opioid analgesic consumption at country, global, and regional levels in 2010, its relationship with development level, and changes compared with 2006. Journal of Pain and Symptom Management. 2014;47(2):283–297.
Jemal A, Torre L, Street W, Bray F. The Cancer Atlas – ACS.3rd ed. Atlanta; American Cancer Society; 2019:1–69
Daryono BS, Rahmadani WD. Identification of Bawang Sabrang (Eleutherine americana Merr . Ex K . Heyne ) in Indonesia Based on Chromosome Characters. Indonesia Journal of Pharmacy. 2013;24(1):22–9.
Luardini MA, Asi N, Garner M. Ecolinguistics of ethno-medicinal plants of the Dayak Ngaju community. Language Science. 2019;74:77-84
Park CM, Song YS. Luteolin and luteolin-7-o-glucoside inhibit lipopolysaccharide-induced inflammatory responses through modulation of NF - κB/Ap-1/PI3K-AKT signaling cascades in RAW 264.7 cells. Nutrition research and practice. 2013;7(6):423–429.
Naspiah N, Iskandar Y, Moelyono MW. Review Article: Tiwai Onion (Eleutherine americana Merr.), multifunction plant. Indonesian Journal of Applied Sciences. 2014;4(2):18–30.
Borghi SM, Pinho-Ribeiro FA, Fattori V, Bussmann AJC, Vignoli JA, Camilios-Neto D, et al. Quercetin inhibits peripheral and spinal cord nociceptive mechanisms to reduce intense acute swimming-induced muscle pain in mice. PLoS ONE. 2016;11(9):1–23.
Suprapti T. Praktikum Farmasetika Dasar. Kementerian Kesehatan Republik Indonesia. 2016;1(2):61–68.
Mulder G., Pritchett-Corning K. Rodent analgesiometry: The hot plate, tail flick dan Von Frey hairs. Contemporary topics in laboratory animal science/American Association for Laboratory Animal Science. 2004; 43(3):54–55
Ruiz-Miyazawa KW, Staurengo-Ferrari L, Mizokami SS, Domiciano TP, Vicentini FTMC, Camilios-Neto D, et al. Quercetin inhibits gout arthritis in mice: induction of an opioid-dependent regulation of inflammasome. Inflammopharmacology. 2017;25(5):555–570.
Backhouse N, Delporte C, Apablaza C, Farías M, Goí¯ty L, Arrau S, et al. Antinociceptive activity of Buddleja globosa (matico) in several models of pain. J Ethnopharmacol. 2008;119(1):160–165.
Ribeiro N, Abreu T, Chaves H, Bezerra M, Monteiro H, Jorge R et al. Sulfated polysaccharides isolated from the green seaweed Caulerpa racemosa plays antinociceptive and anti-inflammatory activities in a way dependent on HO–1 pathway activation. Inflammation Research. 2014;63(7):569-580.
Idrus HRA, Iswahyudi, Wahdaningsih S. Uji Aktivitas Antioksidan Ekstrak Etanol Daun Bawang Mekah (Eleutherine americana Merr.) Terhadap Gambaran Histopatologi Paru Tikus (Rattus norvegicus) Wistar Jantan Pasca Paparan Asap Rokok. Jurnal Fitofarmaka Indonesia. 2014;1(2):51–60.
Sastyarina Y. Uji toksisitas akut dan subakut pada pemberian ekstrak etanol bawang tiwai (Eleutherine americana Merr.). Journal of Tropical Pharmacy and Chemistry. 2013;2(2):18–124.
1. The journal allows the author to hold the copyright of the article without restrictions.
2. The journal allows the author(s) to retain publishing rights without restrictions
3. The legal formal aspect of journal publication accessibility refers to Creative Commons Attribution Share-Alike (CC BY-SA).
