A Systematical Review of The Effect of Ketogenic Diet on Bcl-2 (B-cell lymphoma-2) Expression as An Apoptosis Marker in Cancer Treatment
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Introduction: Ketogenic diet seems to be in a great demand nowadays as a lot of people are interested in adopting it into their lifestyle. It is also found that the ketogenic diet shows several beneficial effects including cancer prevention. However, the detail mechanism still remains unknown. Therefore, this review was aimed to find out the effect of ketogenic diet on Bcl-2 (B-cell lymphoma-2) expression in cancer.
Methods: We searched published literatures in PubMed through 2011-2020 using specific keywords. The literatures were filtered according to inclusion and exclusion criteria. Animal model, total sample size, underlying condition/inflammatory process occurs, details of the intervention/diet including diet contents in control group and high-fat group, and the duration of the intervention, Bcl-2 results, and p-value were extracted.
Results: 7 studies were included in this review. Bcl-2 expression found decrease in 5 out of 6 studies. Similar result also obtained in Bcl-2 protein level, which measured by western blot. Bcl-2 protein level shows a decrease in 2 out of 3 studies.
Conclusion: This review shows that high-fat diet that contained in ketogenic diet most likely lead to decrease in Bcl-2 expression. Therefore, indicating the ability of ketogenic diet to affect cancer progression by inducing apoptosis process.
Shilpa J, Mohan V. Ketogenic diets: Boon or bane?. The Indian journal of medical research. 2018;148(3):251-253.
Kalra S, Singla R, Rosha R, Dhawan M, Khandelwal D, Kalra B. The Ketogenic Diet. US Endocrinology. 2018;14(2):62-64.
WHO. Cancer [Internet]. 2019 [cited 2019 May 27];Available from: https://www.who.int/news-room/fact-sheets/detail/cancer
WHO. Early detection of cancer [Internet]. 2019 [cited 2019 May 27];Available from: https://www.who.int/cancer/detection/en/
National Cancer Institute. Risk Factors for Cancer [Internet]. 2015 [cited 2019 Jun 7];Available from: https://www.cancer.gov/about-cancer/causes-prevention/risk
KamiÅ„ska M, Ciszewski T, Åopacka-Szatan K, MiotÅ‚a P, StarosÅ‚awsk E. Breast cancer risk factors. 2015;14(3):196-202.
Irmawati A, Jasmin N, Sidarningsih. The effect of moderate exercise on the elevation of Bax/Bcl-2 ratio in oral squamous epithelial cells induced by benzopyrene. Veterinary World. 2018;11(2):177-180.
National Cancer Institute. NCI Dictionary of Cancer Terms [Internet]. 2019 [cited 2019 May 27];Available from: https://www.cancer.gov/publications/dictionaries/cancer-terms/def/bcl2
Campbell KJ, Tait SWG. Targeting BCL-2 regulated apoptosis in cancer. Open Biology. 2018;8(5):1-11.
Weber DD, Aminazdeh-Gohari S, Kofler B. Ketogenic diet in cancer therapy. AGING. 2018;10(2):164-165.
Sakr HF, Abbas AM, Khalil K, Shata AM. Modulatory effect of concomitant administration of sitagliptin and vitamin E on inflammatory biomarkers in rats fed with high fat diet: role of adiponectin. Journal of Physiology and Pharmacology. 2019;70(6):955-967.
Liu Y, Zhang Y, Hu M, Li Y, Cao X. Carnosic acid alleviates brain injury through NF"‘κB"‘regulated inflammation and Caspase"‘3"‘associated apoptosis in high fat"‘induced mouse models. Molecular Medicine Reports. 2019;20(1):495-504.
Sahraoui A, Dewachter C, Medina GD, Naeije R, Bouguerra SA, Dewachter L. Myocardial Structural and Biological Anomalies Induced by High Fat Diet in Psammomys obesus Gerbils. PLoS One. 2016;11(2):1-16.
Hill AA, Anderson-Baucum EK, Kennedy AJ, Webb CD, Yull FE, Hasty AH. Activation of NF-κB drives the enhanced survival of adipose tissue macrophages in an obesogenic environment. Molecular Metabolism. 2015;4(10):665-677.
Zhang T, Tian F, Wang J, Jing J, Zhou SS, Chen YD. Atherosclerosis-Associated Endothelial Cell Apoptosis by MiR-429-Mediated Down Regulation of Bcl-2. Cellular Physiology and Biochemistry. 2015;37(4):1421-1430.
Gong WH, Zheng WX, Wang J, Chen SH, Pang B, Hu XM, et al. Coexistence of hyperlipidemia and acute cerebral ischemia/reperfusion induces severe liver damage in a rat model. World Journal of Gastroenterology. 2012;18(35):4934-4943.
Aguiar e Silva MA, Vechetti-Junior IJ, Ferreira do Nascimento A, Furtado KS, Azevedo L, Ribeiro DA, et al. Effects of swim training on liver carcinogenesis in male Wistar rats fed a low-fat or high-fat diet. Applied Physiology, Nutrition, and Metabolism. 2012;37(6):1101-1109.
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