Antioxidant Face Cream Formulation of Ethanol Extract from Soursop leaves (Annona muricata L)
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Face cream was a treatment cream used to treat facial skin. One of the natural plant ingredients that could be used as an active substance in cream preparations was soursop leaves (Annona muricata L.), which had antioxidant activity. The purpose of this study was to formulate cream preparations from soursop leaf ethanol extract and test the antioxidant activity on face cream preparations. Soursop leaves were extracted by maceration using a 96% ethanol solvent. Cream preparations in physical quality evaluation included organoleptic test, pH test, homogeneity test, viscosity test, spread power test, sticking power test, centrifugation test, and determination of emulsion type and antioxidant activity test with DPPH method, measured at a wavelength of 511,5 nm using UV-Vis spectrophotometry. The results of this study produced a face cream preparation of soursop leaf ethanol extract with differences in color in organoleptic cream preparations. pH tests of FI, FII, and FIII creams had an average yield of 6,0-6,6. The homogeneity tests of FI, FII, and FIII showed homogeneous results. The viscosity test had a value of 49950 cPs. The FI, FII, and FIII spread power tests had good results with an average of 5,2-5,7 cm. FI, FII, and FIII sticking power tests had an average value of 26,5-46,5 seconds. FI, FII, and FIII centrifugation tests were physically stable, and the determination of the type of cream emulsion was type M/A. Testing the antioxidant activity of facial cream with ethanol extract of soursop leaves in FI with a concentration of 3% showed an IC50 value of 80,64 ppm, FII with a concentration of 5% showed an IC50 value of 46,06 ppm, and FIII with a concentration of 7% showed an IC50 value of 10,91 ppm. Based on the results of the study, it could be concluded that the preparation of facial cream with ethanol extract of soursop leaves in FI, FII, and FIII met the physical stability requirements based on organoleptic test parameters, pH test, homogeneity test, viscosity test, spread power test, sticking power test, centrifugation test, and determination of emulsion type. FI cream preparations had an IC50 value of 80,64 ppm, indicating strong antioxidant activity, FII had an IC50 value of 46.06 ppm, indicating very strong antioxidant activity, and FIII had an IC50 value of 10,91 ppm, indicating very strong antioxidant activity.
Keywords: Cream, Formulation, Antioxidant, Ekstrak, Soursop Leaves
Alam, N., & Bristi, N. J. (2013) 'Review on in vivo and in vitro methods evaluation of antioxidant activity' Saudi Pharmaceutical Journal, 21(2), 143–152. doi:10.1016/j.jsps.2012.05.002
Depkes RI. (2020) 'Farmakope Indonesia Edisi VI' Departemen Kesehatan RI, Jakarta.
Edy, H. J., Marchaban, S., Wahyuono, & Nugroho, A. E. (2016) 'Formulasi dan Uji Sterilitas Hidrogel Herbal Ekstrak Etanol Daun Tagetes erecta L', Pharmacon, 5(2), 9–16.
Himaniarwati, Nikeherpianti L., Nur Herlina, & Dzul Chulaifah. (2019) 'Optimasi Sediaan Krim dari Ekstrak Etanol Daun Muda Pepaya (Carica papaya L.) Sebagai Antioksidan', Sekolah Tinggi Ilmu Kesehatan Mandala Waluya Kendari.
Hasmila ita, Amaliah, & Danial M. (2015) 'Efektivitas Salep Ekstrak Ekstrak Daun Sirsak (Annona muricata L.) Pada Mencit yang Terinfeksi Bakteri Staphylococcus aureus', Universitas Negeri Makassar, Makassar.
Hakim, R. Z., Dewi Meliana, & Pri Iswati U. (2020) 'Formulasi dan Uji Sifat Fisik Sediaan Lulur Krim dari Ekstrak Etanol Daun Sirsak (Annona muricata L.) Serta Penentuan Aktivitas Antioksidannya', Jurnal Sains Farmasi & Klinis, Universitas Muhammadiyah Purwokerto, Jawa Tengah.
Kharisma, D. N. I., & Safitri, C. I. N. H. (2020) 'Formulasi dan Uji Mutu Fisik Sediaan Gel Ekstrak Bekatul (Oryza sativa L.)', Akademi Farmasi Mitra Sehat Mandiri Sidoarjo, Sidoarjo.
Kumara, P., Sunil, K., & B, A. K. (2018) 'Natural Products Chemistry & Determination of DPPH Free Radical Scavenging Activity by RP-HPLC Rapid Sensitive Method for the Screening of Berry Fruit Juice Freeze Dried Extract', 6(5). doi:10.4172/2329-6836.1000341
Mailana, D., Nuryanti, & Harwoko. (2016) 'Formulasi Sediaan Krim Antioksidan Ekstrak Etanolik Daun Alpukat (Persea americana Mill.)', Universitas Jenderal Soedirman, Purwokerto.
Padaleti, M. P., Yohaha, K. A. Mbulangb, & Novi Winda Lutsina 'Formulasi dan Teknologi Sediaan Krim dan Salep Ekstrak Daun Sirsak (Annona muricata L.)', STIKes Citra Husada Mandiri Kupang.
Pratasik, M. C., Paulina V. Y. Yamlean, & Wiyono, I. Weny. (2019) 'Formulasi dan Uji Stabilitas Fisik Sediaan Krim Ekstrak Etanol Daun Sesewanua (Clerodendron squamatum Vahl.)', Universitas Sam Ratulangi.
Putri, A. N. R. (2012) 'Uji Aktivitas Antioksidan Ekstrak Daun Sirsak (Annona Muricata L.) Dengan Metode DPPH (1,1-Diphenyl-2-Picrylhydrazil)', Universitas Islam Negeri Syarif Hidayatullah, Jakarta.
Riska, T., Edy J. Hosea, & Jayanto I. (2020) 'Formulasi Sediaan Krim Kombinasi Ekstrak Daun Seledri (Apium graveolens L.) dan Daun Jati (Tectona grandis Linn.f) Sebagai Antibakteri Terhadap Staphylococcus Aureus', Universitas Sam Ratulangi, Manado.
Rock, L., & Brunswick, N. (2005) 'Standardized Methods for the Determination of Antioxidant Capacity and Phenolics in Foods and Dietary Supplements', 4290–4302.
Tampobolon, B. N. (2020) 'Pengaruh Masker Daun Sirsak (Annona muricata Linn) Terhadap Kulit Wajah Berjerawat', Universitas Negeri Jakarta.
Takarina Maulida, R. (2019) 'Uji Efektivitas Krim Anti-aging Ekstrak Etanol Daun Sirsak (Annona muricata L.)', Universitas Sumatera Utara, Medan.
Wardiyah, S. (2015) 'Perbandingan Sifat Fisik Krim, Gel, dan Salep yang Mengandung etil p-Metoksisinamat dari Ekstrak Rimpang Kencur (Kaempferia galanga Linn.)', Universitas Islam Negeri Syarif Hidayatullah, Jakarta.
Yumas, Medan. (2016) 'Formulasi Sediaan Krim Wajah Berbahan Aktif Ekstra Metanol Biji Kakao Non Fermentasi (Theobroma cacao L.) Kombinasi Madu Lebah', Balai Besar Industri Hasil Perkebunan, Makassar
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