Improving the Bioavailability of Curcumin in Curcuma heyneana by Preparing Solid Dispersion
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Curcuma heyneana or Temu Giring contains curcumin which has anti-aging potential and is traditionally used as a body scrub. This potential comes from the active ingredient (curcumin) which can prevent premature aging with its activity as an antioxidant, inhibitor of the tyrosinase enzyme, and inhibitor of the collagenase enzyme. So, it can prevent hyperpigmentation and inhibit the breakdown of collagen which can have an impact on skin aging. Oral dosage forms for anti-aging are starting to be found on the market and becoming a trend because of their convenient use. However, it is known that curcumin as an active ingredient of Temugiring, has poor solubility and bioavailability. The bioavailability of curcumin is low when administered orally due to its low absorption and its stability which decreases significantly when the pH is above 7. This study is a literature review of national and international literature databases that aims to determine the potential for increasing the bioavailability of curcumin using solid dispersion techniques. The results obtained indicate that making Temu Giring extract tablets containing curcumin using the solid dispersion method can increase the bioavailability of curcumin by overcoming the poor solubility, permeability, absorption, and stability of curcumin. By designing the Temu Giring extract using a solid dispersion method, the curcumin can be completely dissolved and released into the stomach.
Keywords: Curcuma heyneana, Temu Giring, anti-aging, tablet, curcuminoid, antioxidant, solid dispersion.
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