The Effectiveness of Vitamin E Soft Capsules as an Antioxidant
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Antioxidants inhibited the oxidation of other molecules and played an important role in maintaining a healthy body. Antioxidants were found in fruits, vegetables, all parts of plants, and were present in the body as enzymes or products of metabolism. Vitamin E referred to a large number of natural or synthetic compounds, with alpha-tocopherol being the most active and widely distributed form in nature. Alpha-tocopherol was the most active antioxidant form of vitamin E and served as the primary lipophilic antioxidant in plasma, membranes, and tissues. The most important function of vitamin E was its antioxidant capability, counteracting free radical attacks that could damage cells and cause various degenerative diseases. Additionally, antioxidants helped reduce the effects of photoaging on the skin, potentiated anti-aging and anti-inflammatory activity, increased the rate of wound healing, and helped maintain healthy eyes and the immune system. One form of vitamin E dosage form was a soft capsule, which had several advantages, including the ease of filling the Active Pharmaceutical Ingredient (API) in liquid form, higher production capacity, and formulation uniformity compared to gelatin tablets or hard capsules. Soft capsule preparations also had rapid API release, which could result in achieving therapeutic blood levels more quickly and achieving greater bioavailability. This study aimed to evaluate soft capsule dosage forms in enhancing the effectiveness of vitamin E as an antioxidant. The research utilized review articles sourced from national and international journals, as well as scientific journals. The results showed that vitamin E supplementation in soft capsules could increase its effectiveness as an antioxidant.
Keywords: Soft Capsule, Increase Effectiveness, α-tocopherol, Vitamin E, Antioxidant
Agustina, H., et al. (2020) ‘Korelasi Asupan Vitamin E dengan Kadar Hemoglobin pada Ibu Hamil di Puskesmas Kaliwiro Tahun 2019', Seminar Nasional Riset Kedokteran, pp. 187-192. (online)
Angelia, L. M. (2014) Hubungan Gizi dan Penyakit. Fakultas Kesehatan Masyarakat: Universitas Sriwijaya.
Aulton, M. and Taylor, K. (2013) Aulton's Pharmaceutics: The design and manufacture of medicines. London: Churchill Livingstone Elsevier.
Basuki, Santosa. and Devitasari, R. (2022) ‘Manfaat Vitamin E pada Kulit', Jurnal Klinik dan Riset Kesehatan, 1(2), pp. 116-126.
Bende, G. (2016) ‘Relative Bioavailability of Diclofenac Potassium From Softgel Capsule Versus Powder for Oral Solution and Immediate-Release Tablet Formulation', Clinical Pharmacology in Drug Development, 5(1), pp. 76-82.
Çakmakçı, S., Topdaş, E. F., Kalın, P., Han, H., Åžekerci, P., Köse, L. and Gülçin, Ä°. (2014) ‘Antioxidant capacity and functionality of oleaster (Elaeagnus angustifolia L.) flour and crust in a new kind of fruity ice cream', International Journal of Food Science & Technology, 50(2), pp. 472–481.
Canales. (2019) ‘The Effect of Alpha-Tocopherol on the Activity of Acetylcholinesterases from Different Sources', Neurochem Journal, 13(1), pp. 36–42.
Damian, F. et al. (2021) ‘Challenges of Dissolution Methods Development for Soft Gelatin Capsules', Pharmaceutics, 13, p. 214.
Deepak, G., Kamal, K., Bilandi, A., and Kataria, M. (2014) ‘Soft Gelatin Capsules: Development, Applications and Recent Patents', International Research Journal of Inventions in Pharmaceutical Sciences, 2(3), pp. 163-168.
Fadlilah, A. R. and Lestari, K. (2023) ‘Peran Antioksidan dalam Imunitas Tubuh', Farmaka, 21(2).
Fakriah, E. K., Adriana, and Rusydi (2019) ‘Sosialisasi Bahaya Radikal Bebas dan Fungsi Antioksidan Alami Bagi Kesehatan', Jurnal Vokasi, 3(1). (online). ISSN: 2548-4117.
Fu, J., Che, H., Tan, D. M., and Teng, K. (2014) ‘Bioavailability of tocotrienols: evidence in human studies', Nutrition and Metabolism, 11(5), pp. 1-10.
Galli, F., Azzi, A., Birringer, M., Cook-Mills, J. M., Eggersdorfer, M., Frank, J., and Özer, N. K. (2017) ‘Vitamin E: Emerging aspects and new directions', Free Radical Biology and Medicine, 102, pp. 16-36.
Granato, D., Shahidi, F., Wrolstad, R., Kilmartin, P., Melton, L. D., Hidalgo, F. J., and Finglas, P. (2018) ‘Antioxidant activity, total phenolics and flavonoids contents: Should we ban in vitro screening methods?', Food Chemistry, 264, pp. 471–475.
Grilo, E. C., Costa, P. N., Gurgel, C. S. S., Beserra, A. F. de L., Almeida, F. N. de S., and Dimenstein, R. (2014) ‘Alpha-tocopherol and gamma-tocopherol concentration in vegetable oils', Food Science and Technology, 34(2), pp. 379–385.
Gulcin, Ä°. (2020) ‘Antioxidants and antioxidant methods: an updated overview', Archives of Toxicology, 94, pp. 651–715.
Gullapalli, R. P. (2010) ‘Soft Gelatin Capsules (Softgels)', Journal of Pharmaceutical Sciences, 99(10), pp. 4107-4148.
Gullapalli, R. P. and Mazzitelli, C. L. (2017) ‘Gelatin and non-gelatin capsule dosage forms', Journal of Pharmaceutical Sciences, 106(6), pp. 1453-1465.
Hobson, R. (2016) ‘Vitamin E and wound healing: an evidence-based review', International Wound Journal, 13(3), pp. 331-335.
Joshi, S., Sahu, R., Dennis, V. A., and Singh, S. R. (2021) ‘Nanofiller-enhanced soft non-Gelatin alginate capsules for modified drug delivery', Pharmaceuticals, 14(4), p. 355.
Katrin, K. and Bendra, A. (2015) ‘Aktivitas Antioksidan Ekstrak, Fraksi dan Golongan SenyawaKimia Daun Premna oblongata Miq.', Pharmaceutical Sciences and Research, 2(1), p. 3.
Kotha, R. R., Tareq, F. S., Yildiz, E., and Luthria, D. L. (2022) ‘Oxidative Stress and Antioxidants: A Critical Review on In Vitro Antioxidant Assays', Antioxidants, 11, p. 2388.
Lee, G. and Han, S. (2018) ‘The Role of Vitamin E in Immunity', Nutrients, 10(11), p. 1614. doi:10.3390/nu10111614.
Marianela, C. Rojas., et al. (2021) ‘Gelatin and Non-gelatin Soft Gel Capsules: A review', Journal of Excipients and Food Chemicals, IPEC-Americas, pp. 19-20.
Matsumoto, L. T. A., Sampaio, G. R., and Bastos, D. H. M. (2018) ‘Stability of antioxidant vitamins in commercial vitamin supplements', Brazilian Journal of Pharmaceutical Sciences, 52(4).
Michalak, M., Pierzak, M., Kręcisz, B., and Suliga, E. (2021) ‘Bioactive Compounds for Skin Health: A Review', Nutrients, 13(1), p. 203. Available at: http://dx.doi.org/10.3390/nu13010203
MiroÅ„czuk-Chodakowska, I., Witkowska, A. M., and Zujko, M. E. (2018) ‘Endogenous non-enzymatic antioxidants in the human body', Advances in Medical Sciences, 63(1), pp. 68–78.
Misic, Z., Muffler, K., Sydow, G., and Kuentz, M. (2012) ‘Novel starch"based PVA thermoplastic capsules for hydrophilic lipid"based formulations', Journal of Pharmaceutical Sciences, 101(12), pp. 4516-4528.
Mohd Zaffarin, A. S., Ng, S. F., Ng, M. H., Hassan, H., and Alias, E. (2020) ‘Pharmacology and pharmacokinetics of Vitamin E: Nanoformulations to enhance bioavailability', International Journal of Nanomedicine, 15, pp. 9961–9974.
Mohseni, N., Najafpour, D. G., Ramezani, R., and Jahani, A. (2022) ‘A developed composite hard-gelatin capsules: delayed-release enteric properties', Heliyon, 8(12), p. e12265.
Mubarak, K., Natsir, H., Wahab, A. W., and Satrimafitrah, P. (2017) ‘Analisis kadar α-tokoferol (vitamin E) dalam daun kelor (Moringa oleifera Lam) dari daerah pesisir dan pegunungan serta potensinya sebagai antioksidan', KOVALEN: Jurnal Riset Kimia, 3(1), pp. 78-88.
Muller, M. A., Christian, S., Gilberto, L., Anna, M. K., Maret, G. T., Adrian, W., Theo, R., Manfred, E., and Werner, B. (2022) ‘100 Years of Vitamin E: From Discovery to Commercialization', European Journal of Organic Chemistry, p. e202201190.
Park, J.-E., Kim, K.-E., Choi, Y.-J., Park, Y.-D., and Kwon, H.-J. (2015) ‘The stability of water- and fat-soluble vitamin in dentifrices according to pH level and storage type', Biomedical Chromatography, 30(2), pp. 191–199.
Péter, S., Moser, U., Pilz, S., Eggersdorfer, M., and Weber, P. (2013) ‘The Challenge of Setting Appropriate Intake Recommendations for Vitamin E: Considerations on Status and Functionality to Define Nutrient Requirements', International Journal for Vitamin and Nutrition Research, 83(2), pp. 129-136.
Prawira, A. Y., Farida, W. R., Darusman, H. S., Novelina, S., and Agungpriyono, S. (2018) ‘Vitamin E (Alpha Tocopherol) Level in the Dorsal Skin of Sunda Porcupine (Hystrix javanica)', Jurnal Riset Veteriner Indonesia (Journal of The Indonesian Veterinary Research), 2(2).
Proietti, S., Carlomagno, G., Dinicola, S., and Bizzarri, M. (2014) ‘Soft gel capsules improve melatonin's bioavailability in humans', Expert Opinion on Drug Metabolism & Toxicology, 10(9), pp. 1193–1198.
Rich et al. (2012) ‘Formulation and Delivery Method to Enhance Antioxidant Potency of Vitamin E', US Patent.
Rizvi, S., Raza, S. T., Ahmed, F., Ahmad, A., Abbas, S., and Mahdi, F. (2014) ‘The role of vitamin e in human health and some diseases', Sultan Qaboos University Medical Journal. PMCID: PMC3997530.
Sinagal, R. N., et al. (2018) ‘Pengaruh Pemberian Vitamin E terhadap Kadar Hemoglobin pada Aktivitas Fisik Submaksimal', Jurnal Kesehatan dan Olahraga, 2(1).
Srividya, B., Sowmya, C., and Surya, P. R. (2014) ‘Capsule and It's Technology: an Overview', International Journal of Pharmaceutics and Drug Analysis, 2(9), pp. 727-733.
Sweetman, S. C. (2014) Martindale The Complete Drug Reference. 38th ed. London: The Pharmaceutical Press.
Van Kempen, T. A. T. G., Benítez Puñal, S., Huijser, J., and De Smet, S. (2022) ‘Tocopherol more bioavailable than tocopheryl-acetate as a source of vitamin E for broilers', PLoS One, 17(5), e0268894.
Wallert, M., Schmölz, L., Galli, F., Birringer, M., and Lorkowski, S. (2014) ‘Regulatory metabolites of vitamin E and their putative relevance for atherogenesis', Redox Biology, 2, pp. 495-503.
Werdhasari, A. (2014) ‘Peran antioksidan bagi kesehatan', Jurnal Biotek Medisiana Indonesia, 3(2), pp. 59-68.
Yadav, A., Kumari, R., Yadav, A., Mishra, J. P., Srivastava, S., and Prabha, S. (2016) ‘Antioxidants and its functions in human body - A Review', Research in Environment and Life Science, 9, pp. 1328-1331.
Yap, B. K., and Gam, L. H. (2019) ‘Differentiation of bovine from porcine gelatin capsules using gel electrophoresis method', Food Chemistry, 274, pp. 16-19. ISSN 0308-8146.
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